Browsing by Autor "Alberto Giménez-Turba"

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Antiprotozoal activity of Betulinic acid derivatives
(Elsevier BV, 2009) Dafne B Domínguez-Carmona; Fabiola Escalante‐Erosa; Karlina García‐Sosa; Grace Ruiz-Pinell; David Gutierrez-Yapu; Manuel Jesús Chan-Bacab; Alberto Giménez-Turba; Luis M. Peña-Rodrı́guez
Cytotoxic and antiprotozoal activity of flavonoids from Lonchocarpus spp.
(Elsevier BV, 2007) Rocı́o Borges-Argáez; L. Balnbury; A Flowers; Alberto Giménez-Turba; Grace Ruiz; Peter G. Waterman; Luis M. Peña-Rodrı́guez
Ethnopharmacology of Wild Plants
(2020) Amner Muñoz-Acevedo; María Carmen González; Alma Polo-Barrios; Martha Cervantes Díaz; Ricardo D.D.G. de Alburquerque; Ninoska Flores; Alberto Giménez-Turba; María Elena Cazar; Chabaco Armijos; Omar Malagón-Avilés
The traditional herbal healers, along with wild medicinal plants and the knowledge they have about them, in certain regions of Latin America, are the prevalent alternatives for some people/communities to cover any primary health care requirements (e.g., treatment to prevent/improve/release pain/symptoms/disorders/diseases). traditional (plant-based) medicine has gained worldwide acceptance because the plants used for this purpose have been apparently efficacious and safe for a long time (decades/centuries),\nthese being some reasons why the WHO created the traditional, complementary and integrative unit. (WHO 2019).\nDespite this, it is important to remember (i) what “ethnopharmacology” studies are about, which are, shortly, the uses, possible action modes, and bioproperties of plant-based preparations; and (ii) the contribution made by phytochemistry and pharmacology along with other related sciences (botany, pharmacy, microbiology, virology, parasitology, etc.) to find/check any biologically active drugs (molecules/fractions/extracts). In that sense, traditional medicine systems need more evidence-based studies that allow establishing the pharmacological potential together with the validation of therapeutic uses of medicinal plants and its chemical constituents [isolated or mixtures (fractions/extracts)] in such a way that safety and effectiveness are verified, as well as to reveal/understand their preventive and/or therapeutic mechanisms (Mukherjee et al. 2010, Schmidt and Klaser-Cheng 2017).
Exploratory assessment of the chemical and antioxidant potential of Apis mellifera honeys from Santa Cruz, Bolivia
(Elsevier BV, 2026) Jose A. Limpias-Hurtado; Natalia Montellano Duran; Alberto Giménez-Turba; Nélida Nina
This preliminary exploratory study investigates the chemical composition and antioxidant potential of Apis mellifera honeys from Santa Cruz, Bolivia, a region with notable honey production but limited data. Eleven samples collected between 2023 and 2024 were processed to obtain enriched extracts (EE) using solid-phase extraction. Chemical profiles were obtained by TLC and HPLC. Total phenolics, flavonoids, and antioxidant capacity (DPPH•, TEAC, FRAP) were determined spectrophotometrically. Profiles revealed compositional differences, with tentative identification of phenolic acids, hydroxycinnamic acids, and flavonoid derivatives. Total phenolics ranged from 3.57 to 24.95 mg GAE/100 g of honey, and TEAC from 0.37 to 2.10 μmol TE/g honey. Notably, sample M11, with Tessaria spp. reported as a dominant floral source, exhibited the highest antioxidant potential, suggesting interest for functional applications. Darker honeys generally had higher antioxidant capacity, though not always reflecting chemical diversity. These findings highlight the complex bioactive composition of Bolivian honeys and the role of floral and environmental factors.
In vitro Antiprotozoal Activity and Chemical Composition of Ambrosia tenuifolia and A. scabra Essential Oils
(SAGE Publishing, 2008) Valeria P. Sülsen; Silvia I. Cazorla; Fernanda M. Frank; Paola M. R. Di Leo Lira; Claudia Anesini; David Gutierrez-Yapu; Alberto Giménez-Turba; Arnaldo L. Bandoni; Emilio L. Malchiodi; Liliana Muschietti
The in vitro antimalarial, trypanocidal and leishmanicidal activities and the chemical composition of Ambrosia tenuifolia and A. scabra essential oils were investigated. The oils, obtained by hydrodistillation of the aerial parts, showed significant antimalarial activity against the chloroquine sensitive (F32) and the chloroquine resistant (W2) strains of Plasmodium falciparum with 50% inhibitory concentration (IC 50 ) values ranged from 2.8 to 7 μg/mL. Against Trypanosoma cruzi epimastigotes, only A. tenuifolia exerted slight activity (IC 50 = 59.7 μg/mL). None of the essential oils showed toxicity towards Leishmania mexicana. Cytotoxicity for murine T-lymphocytes was compared with the parasiticidal activity by using the selectivity index (SI) ratio. The chemical composition of A. tenuifolia and A. scabra essential oils was analyzed by GC-FID-MS. Thirty-eight and twenty-four compounds were identified in A. tenuifolia and A. scabra, respectively. The major constituents of A. tenuifolia oil were germacrene D (22.9%) and bicyclogermacrene (14.2%), while the oil of A. scabra contained limonene (22.0%), caryophyllene oxide (13.8%) and ( E)-caryophyllene (13.5%). This is the first time that the antiprotozoal activity of both oils and the chemical composition of A. scabra essential oil have been reported.
Leishmanicidal Activity and Immunomodulatory Effect of a Mixture of Lupenone and β-Caryophyllene Oxide
(Springer Science+Business Media, 2021) Glendy Polanco-Hernández; Alberto Giménez-Turba; Efraín Salamanca; Giulia Getti; Rajeev Rai; Karla Y. Acosta-Viana; Víctor Ermilo Arana‐Argáez; Julio César Torres‐Romero; Karla Fernández-Martín; Maira Rubí Segura Campos
Metabolites from roots of Colubrina greggii var. yucatanensis and evaluation of their antiprotozoan, cytotoxic and antiproliferative activities
(Brazilian Chemical Society, 2011) Dafne B Domínguez-Carmona; Fabiola Escalante‐Erosa; Karlina García‐Sosa; Grace Ruiz-Pinell; David Gutierrez-Yapu; Manuel Jesús Chan-Bacab; Rosa Moo‐Puc; Nigel C. Veitch; Alberto Giménez-Turba; Luis M. Peña-Rodrı́guez
A purificao do extrato da raiz de Colubrina greggii var. yucatanensis levou ao isolamento e identificao do cido 3-O-acetil ceantico, um novo triterpeno natural, juntamente com os metablitos j descritos: cido ceantico, cido cenotnico, cido betulnico, discarina B e crisofanena. Os produtos naturais e os derivados semi-sintticos ster de acetil dimetil ceanotato, dimetil ceanotato e peracetato de crisofanena mostraram moderada a baixa atividade leishmanicida e tripanocida. Nenhum dos metablitos mostrou ser citotxicos ou ter atividade antiproliferativa. Os resultados tambm sugerem que o cido betulnico contribui para a atividade antiplasmdica inicialmente detectada na raiz do extrato bruto de C. greggii var. yucatanensis
Promising Antimicrobial Agents from Some Latin American Medicinal Plants Against Disease-Causing Pathogens in Humans and Animals
(2022) Amner Muñoz-Acevedo; María C. González; Osnaider J. Castillo; Cindy P. Guzmán; Sandra Rodríguez-Acosta; Martha Cervantes Díaz; Ricardo D.D.G. de Alburquerque; Bettina Monika Ruppelt; Ninoska Flores; Alberto Giménez-Turba
Synergistic Effect of Lupenone and Caryophyllene Oxide againstTrypanosoma cruzi
(Hindawi Publishing Corporation, 2013) Glendy Polanco-Hernández; Fabiola Escalante‐Erosa; Karlina García‐Sosa; María E. Rosado; Eugenia Guzmán-Marı́n; Karla Y. Acosta-Viana; Alberto Giménez-Turba; Efraín Salamanca; Luis M. Peña-Rodrı́guez
The in vitro trypanocidal activity of a 1 : 4 mixture of lupenone and caryophyllene oxide confirmed a synergistic effect of the terpenoids against epimastigotes forms of T. cruzi (IC50 = 10.4 μ g/mL, FIC = 0.46). In addition, testing of the terpenoid mixture for its capacity to reduce the number of amastigote nests in cardiac tissue and skeletal muscle of infected mice showed a reduction of more than 80% at a dose level of 20.8 mg·kg(-1)·day(-1).
Trypanocidal activity of South American Vernonieae (Asteraceae) extracts and its sesquiterpene lactones
(Taylor & Francis, 2020) A Sosa; Efraín Salamanca; Susana Amaya; Alicia Bardón; Alberto Giménez-Turba; Nancy Vera; Susana Borkosky
Chagas disease is caused by Trypanosoma cruzi and affects the poorest population in the Americas. Fourteen plant extracts and seventeen sesquiterpene lactones from the tribe Vernonieae (Asteraceae), were evaluated for the first time against T. cruzi. Cytotoxicity employing HeLa cells was also assessed. The best results were obtained with leaves and flowers rinse extracts from Vernonanthura nebularum (E-1 and E-3) and Elephantopus mollis (E-11 and E-13), with IC50 values <2 µg/mL, being E-1 the most active (IC50 = 0.8 µg/mL). Additionally, these extracts displayed a good selectivity (SI > 10). The most active sesquiterpene lactones, isolated from the extracts, were 2 (2-methoxy-2,5-epoxy-8-methacryloxygermacra-3Z,11(13)-dien-6,12-olide) and 6 (2-ethoxy-2,5-epoxy-8-angeloxygermacra-3Z,11(13)-dien-6,12-olide) from V. nebularum and 12 (8α-methacryloxyhirsutinolide 13-O-acetate) from V. pinguis, with IC50 of 1.5, 2.1 and 2.0 µM, respectively. These compounds showed SI values >14, better than those of the reference drug nifurtimox. Plants living in South American ecosystems could become a potential source of trypanocidal agents.