Browsing by Autor "Alberto Lazari"

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    Cueing motor memory reactivation during NREM sleep engenders learning-related changes in precuneus and sensorimotor structures
    (2022) Martyna Rakowska; Paulina Bagrowska; Alberto Lazari; Miguel Navarrete; Mahmoud E. A. Abdellahi; Heidi Johansen‐Berg; Penelope A. Lewis
    Abstract Memory reactivation during Non-Rapid Eye Movement (NREM) sleep is important for memory consolidation but it remains unclear exactly how such activity promotes the development of a stable memory representation. We used Targeted Memory Reactivation (TMR) in combination with longitudinal structural and functional MRI to track the evolution of a motor memory trace over 20 days. We show that repeated reactivation of motor memory during sleep leads to increased precuneus activation 24 h post-TMR. Interestingly, a decrease in precuneus activity over the next 10 days predicts longer-term cueing benefit. We also find both functional and structural changes in sensorimotor cortex in association with effects of TMR 20 days post-encoding. These findings demonstrate that TMR can engage precuneus in the short-term while also impacting on task-related structure and function over longer timescales.