Browsing by Autor "Alexandra Heath"

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ANGIOPLASTÍA PERCUTÁNEA EN COARTACIÓN AORTICA
(2010) Alexandra Heath; Jorge Villanueva; Franz Freudenthal; Janne Mendes; Edgar Pozo; A. Gómez Sánchez
Challenges and Special Aspects of Pulmonary Hypertension in Middle- to Low-Income Regions
(Elsevier BV, 2020) Babar Hasan; Georg Hansmann; Werner Budts; Alexandra Heath; Zahra Hoodbhoy; Zhi‐Cheng Jing; Martin Köestenberger; Katharina Meinel; Ana Olga Mocumbi; G. Radchenko
Challenges and special aspects related to the management and prognosis of pulmonary hypertension (PH) in middle- to low-income regions (MLIRs) range from late presentation to comorbidities, lack of resources and expertise, cost, and rare options of lung transplantation. Expert consensus recommendations addressing the specific challenges for prevention and therapy of PH in MLIRs with limited resources have been lacking. To date, 6 MLIR-PH registries containing mostly adult patients with PH exist. Importantly, the global prevalence of PH is much higher in MLIRs compared with high-income regions: group 2 PH (left heart disease), pulmonary arterial hypertension associated with unrepaired congenital heart disease, human immunodeficiency virus, or schistosomiasis are highly prevalent. This consensus statement provides selective, tailored modifications to the current PH guidelines to address the specific challenges faced in MLIRs, resulting in the first pragmatic and cost-effective consensus recommendations for PH care providers, patients, and their families.
Chronic hypobaric hypoxia, patent arterial duct and a new interventional technique to close it
(Cambridge University Press, 2011) Franz Freudenthal; Alexandra Heath; Jorge Villanueva; Janne Mendes; Ximena Vicente; Inge von Alvensleben; Gabriel Echazú; Joaquin Navarro; Nora Lang; Rainer Kozlik‐Feldmann
We conclude that the "Nit-Occlud® PDA-R" device is safe and effective in closing patent arterial duct up to a diameter of 8 millimetres.
Critical barriers for preeclampsia diagnosis and treatment in low-resource settings: An example from Bolivia
(Elsevier BV, 2019) Lilian Toledo‐Jaldin; Sheana Bull; Stephen Contag; Carlos Escudero; Simón Patricio Gutiérrez; Alexandra Heath; James M. Roberts; Jean Scandlyn; Colleen G. Julian; Lorna G. Moore
Developing High Medical Technology, a Challenge for Developing Countries: The Percutaneous Closure of Atrial Septal Defects Using Nit-Occlud ASD-R: Early and Mid-term Results
(SAGE Publishing, 2019) Alexandra Heath; Inge von Alvensleben; Joaquin Navarro; Gabriel Echazú; Rainer Kozlik‐Feldmann; Franz Freudenthal
The Nit-Occlud ASD-R device is safe and effective with very good closure rates.
Preclinical evaluation of a new self‐expanding device for closure of muscular ventricular septal defects in a pig model
(Wiley, 2009) Nora Lang; Christoph Schmitz; Anja Lehner; Franziska Fuchs; Alexandra Heath; Franz Freudenthal; Bernd J. Wintersperger; Armin Huber; Eckart Thein; Heinrich Netz
Our preclinical study shows successful closure of iatrogenic created mVSDs without residual shunting. The device is characterized by a more controlled deployment, an independent deployment of disk and waist, and a good alignment of the left ventricular disk to the muscular septum.
Prolonged postnatal adaptation and enhanced prevalence of congenital heart diseases due to altitude may contribute to newborn mortality in Bolivia
(Wiley, 2025) Alexandra Heath; Inge von Alvensleben; Jesús Ardiles Spielvogel; Pablo Freudenthal; J. Douglas Trapp; Ivanna Noya; Miguel Gálvez; Fanny Mendizábal; Marcelino Gonzales; Ceylan Apaza
Highland populations suffer from significant infant mortality due to chronic ambient hypoxia, which increases the risk of congenital heart disease (CHD) and neonatal pulmonary hypertension. Neither the prevalence of these conditions nor the effectiveness of neonatal cardiac screening to identify CHD or pulmonary hypertension among neonates born at altitudes >4000 m in Bolivia has been reported. In a study of 1033 newborns in El Alto, Bolivia (4150 m), we determined the prevalence of CHD and prolonged postnatal adaptation. We also tested the accuracy of a neonatal cardiac screening tool in identifying infants with/without these conditions. Finally, diagnoses were contrasted between offspring born to parents of lowland versus highland origin. CHD was found in 54 neonates (5.2%), with the most common diagnoses being patent ductus arteriosus and atrial septal defect. Pulmonary hypertension without CHD was observed in 64 neonates (6.8%), with seven cases of persistent pulmonary hypertension of the newborn (PPHN). The neonatal cardiac screening tool showed a sensitivity of 45% and specificity of 99% for CHD, and 35% sensitivity and 92% specificity for prolonged pulmonary adaptation. Offspring of highland-origin women tended to have increased CHD risk, while those from lower altitudes were predisposed to prolonged postnatal adaptation and PPHN; paternal altitude of origin had no statistic significance but showed same tendency. The high prevalence of relevant CHD and prolonged pulmonary adaptation in neonates born >4000 m in Bolivia likely contributes to the high infant mortality rates observed. The poor sensitivity of the pilot neonatal cardiac screening instrument underscores the need to develop evidence-based tools optimized for use in low-resource, high-altitude settings.
Transcatheter closure of large patent ductus arteriosus at high altitude with a novel nitinol device
(Wiley, 2011) Alexandra Heath; Nora Lang; Daniel S. Levi; Miguel Granja; Jorge Villanueva; Joaquin Navarro; Gabriel Echazú; Rainer Kozlik‐Feldmann; Pedro J. del Nido; Franz Freudenthal
The Nitocclud PDA-R device is safe and effective and can easily close very large PDAs. This device has a high rate of complete occlusion within 1 year and is easily retrieved if embolized.
Weaving Indigenous Textile Art Into Cardiac Devices
(American Medical Association, 2018) Alexandra Heath; Alexander J. Javois; Franz Freudenthal
This Arts and Medicine essay describes how indigenous Aymara women in La Paz, Bolivia, are using traditional weaving techniques and patterns to create cardiac devices for occlusion of large congenital heart defects in children.