Browsing by Autor "Alicia Ortega"
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Item type: Item , MAPAS E ITINERARIOS EN LOS IMAGINARIOS FEMENINOS LATINOAMERICANOS(2005) Alicia Ortega; Susana RosanoItem type: Item , Músculo esquelético: del nacimiento a la vejez, rutas hacia la falla mecánica y metabólica(Academia Nacional de Medicina de México, 2017) Sofía Gitler; I Méndez Ramírez; Ricardo Ramírez; J. Jiménez Medina; P.M. López Vázquez; Alicia OrtegaEl msculo esqueltico (ME) es el tejido ms abundante y el mayor reservorio de protenas del organismo. Transporta glucosa dependiente de insulina por los transportadores GLUT4 y mantiene la concentracin de aminocidos sricos. Por su masa y requerimientos energticos,Item type: Item , PRODUCIR PRESENTE: TOCAR EL CUERPO, ESCRITURA, MUJERES, PAISAJES, AFECTOS Narrativa contemporánea de escritoras en América Latina II(2020) Alicia OrtegaEscrituras que expresan marcas de nuestra contemporaneidadItem type: Item , PRODUCIR PRESENTE: TOCAR EL CUERPO, ESCRITURA, MUJERES, PAISAJES, AFECTOS Narrativa contemporánea de escritoras en América Latina II(2020) Alicia OrtegaEscrituras que expresan marcas de nuestra contemporaneidadItem type: Item , PRODUCIR PRESENTE: TOCAR EL CUERPO, ESCRITURA, MUJERES, PAISAJES, AFECTOS Narrativa contemporánea de escritoras en América Latina II(2020) Alicia OrtegaEscrituras que expresan marcas de nuestra contemporaneidadItem type: Item , Skeletal muscle: from birth to old age, routes to mechanical and metabolic failure.(National Institutes of Health, 2019) Sofía Gitler; I Méndez Ramírez; Ricardo Santiago Ramirez; Joel Medina; Pável Vázquez; Alicia OrtegaSkeletal muscle (SM) is the most abundant tissue and the largest reservoir of protein in the body. It transports glucose in an insulin dependent manner by the glucose transporter type 4 (GLUT4) and contributes in the maintenance of serum amino acids concentration. By its mass and energetic requirements, it is fundamental for the systemic metabolic balance. In the present work, we present the effect of gestational undernourishment (GU) on the mechanical and metabolic properties of SM at birth and in old age in an animal model. Mechanical studies were performed on isolated muscles, while the GLUT4, amino acid transporters LAT2, SNAT2 and insulin receptors (IR) determination were performed on isolated transverse-tubule membranes (TT). The GU in offspring at birth, results in low muscle mass with increased contraction force and resistance to fatigue. However, in two-years old rats, there was muscle hypotrophy and sarcopenia, the force decreased between 50 and 70% in control rats and rats with GU respectively, accompanied by a lower expression of LAT2, SNAT2 and IR in TT. In conclusion, GU irreversibly affects the SM, an effect that could be similar in humans, which help us to understand the events that associate the GU with the metabolic debacle of SM and the metabolic diseases of human adulthood.