Browsing by Autor "Andhika Kurnianta Kusuma"

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Burning Mouth Syndrome: Exploring the Role of Central Sensitization and Neuropathic Pain Mechanisms in Bandung, Indonesia
(2025) Muhammad Ashraf; Syaifudin Syaifudin; Andhika Kurnianta Kusuma; Duru Carissa Neuer; Eduardo Michael Perez
Introduction: Burning mouth syndrome (BMS) is a chronic pain condition characterized by a burning sensation in the oral cavity without any identifiable clinical or laboratory findings. While the etiology of BMS remains unclear, central sensitization and neuropathic pain mechanisms are increasingly recognized as potential contributors. This study aimed to investigate the role of central sensitization and neuropathic pain in BMS patients in Bandung, Indonesia. Methods: This cross-sectional study involved 40 participants diagnosed with BMS according to the International Association for the Study of Pain (IASP) criteria and 40 healthy controls. All participants underwent comprehensive assessments, including: (1) clinical oral examination, (2) quantitative sensory testing (QST) to assess thermal and mechanical sensitivity, (3) questionnaires to evaluate pain intensity, quality of life, anxiety, and depression, and (4) measurement of salivary cortisol levels as a marker of stress. Results: BMS patients exhibited significantly higher thermal and mechanical sensitivity compared to healthy controls (p<0.001). They also reported significantly higher pain intensity, poorer quality of life, and increased levels of anxiety and depression (p<0.001). Salivary cortisol levels were significantly elevated in the BMS group (p<0.05). Correlation analysis revealed significant associations between pain intensity and QST parameters, anxiety, depression, and salivary cortisol levels. Conclusion: The findings of this study suggest that central sensitization and neuropathic pain mechanisms play a significant role in the pathophysiology of BMS in Bandung, Indonesia. These findings highlight the need for a multidisciplinary approach to BMS management, incorporating strategies to address both peripheral and central factors contributing to pain.
Development and Validation of the Indonesian Voice Handicap Index Adapted for Javanese and Sundanese Speakers (I-VHI-JS)
(2025) Hasrita Soleiman; Andhika Kurnianta Kusuma; Eduardo Michael Perez
Introduction: Voice disorders significantly impact quality of life. The Voice Handicap Index (VHI) is a widely used patient-reported outcome measure, but its applicability is limited by linguistic and cultural factors. Indonesia, with its diverse languages, requires culturally adapted versions. This study aimed to develop and validate the Indonesian Voice Handicap Index adapted for Javanese and Sundanese speakers (I-VHI-JS). Methods: The original English VHI was translated into Indonesian, Javanese, and Sundanese using a rigorous forward-backward translation process. A cross-sectional study was conducted involving three groups: (1) individuals with voice disorders (n=150; Javanese speakers = 75, Sundanese speakers = 75), (2) age- and gender-matched vocally healthy controls (n=150; Javanese speakers = 75, Sundanese speakers = 75), and (3) a test-retest reliability group (n=50; Javanese speakers = 25, Sundanese speakers = 25) from the voice disorder group. Participants completed the appropriate I-VHI-JS version. Otolaryngological examination and acoustic voice analysis (jitter, shimmer, noise-to-harmonics ratio) were performed. Internal consistency (Cronbach's alpha), test-retest reliability (intraclass correlation coefficient - ICC), construct validity (known-groups comparison), concurrent validity (correlation with acoustic parameters), and discriminant validity (receiver operating characteristic - ROC curve analysis) were assessed. Results: The I-VHI-JS demonstrated excellent internal consistency (Cronbach's alpha > 0.90 for all versions) and test-retest reliability (ICC > 0.85 for all versions). Significant differences in I-VHI-JS scores were found between the voice disorder and control groups (p < 0.001) for all language versions, confirming construct validity. Moderate correlations were observed between I-VHI-JS scores and some acoustic parameters (e.g., jitter, r = 0.45, p < 0.01; shimmer, r = 0.40, p < 0.01). ROC curve analysis showed excellent discriminant ability (area under the curve - AUC > 0.80 for all versions). Conclusion: The I-VHI-JS is a reliable and valid instrument for assessing voice-related handicaps in Indonesian, Javanese, and Sundanese speakers. It can be used in clinical practice and research to evaluate the impact of voice disorders and monitor treatment outcomes.