Browsing by Autor "Andrea Camera"

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    Aging and putative frailty biomarkers are altered by spaceflight
    (2023) Andrea Camera; Marshall Tabetah; Verónica Castañeda; JangKeun Kim; Aman Singh; Alissen Haro-Vinueza; Ivonne Salinas; Allen Seylani; Shehbeel Arif; Saswati Das
    <title>Abstract</title> Human space exploration is hazardous, causing molecular changes that can alter astronauts' health. This can include genomic instability, mitochondrial dysfunction, increased inflammation, homeostatic dysregulation, and epigenomic changes. These alterations are similar to changes during aging on Earth. However, little is known about the link between these changes and disease development in space. Frailty syndrome is a robust predictor associated with biological aging, however its existence during spaceflight has not been examined. We used murine data from NASA’s GeneLab and astronaut data from JAXA and Inspiration4 missions to evaluate the presence of biological markers and pathways related to frailty, aging and sarcopenia. We identified changes in gene expression that could be related to the development of a frailty-like condition. These results suggest that the parallels between spaceflight and aging may extend to frailty as well. Future studies examining the utility of a frailty index in monitoring astronaut health appear warranted.
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    Key Genes, Altered Pathways and Potential Treatments for Muscle Loss in Astronauts and Sarcopenic Patients
    (2023) Andrés Caicedo; Verónica Castañeda; Juan E. Diaz; Alissen Haro-Vinueza; Jiwoon Park; JangKeun Kim Kim; Eliah Overbey; Ivonne Salinas; Gino Nardocci; Andrea Camera
    <title>Abstract</title> Sarcopenia is characterized by loss of muscle mass and strength in the elderly. Interestingly, astronauts suffer from a sarcopenic-like phenotype due to microgravity, thus effective countermeasures and preventive strategies are needed. Earth precision medicine combined with statistical, co-expression network and pathway analysis enables us to explore gene expression data from people with and without sarcopenia to obtain a list of 21 Key Genes (KGs). We then validated our KGs upon data from human endothelial cells cultured in the International Space Station, and astronauts’ samples from Japan Aerospace Exploration Agency and Inspiration 4 mission. Our results suggest that POMC and GOLGA8R are the most robust biomarkers identified for muscle loss. Finally, a pharmacological screening performed to target our KGs showed that POMC activity can be modulated using phase IV or approved drugs. Combining Earth’s precision medicine with space data is a promising approach to address common conditions related to accelerated aging.