Browsing by Autor "Anne-Isabelle Waechter"

Filter results by typing the first few letters
Now showing 1 - 2 of 2
  • Thumbnail Image
    Item type: Item ,
    Antiprotozoal activity of aporphine alkaloids isolated fromUnonopsis buchtienii (Annonaceae)
    (Wiley, 1999) Anne-Isabelle Waechter; André Cavé; Reynald Hocquemiller; Christian Bories; Victoria Muñoz; Alain Fournet
    On a preliminary screening, substantial leishmanicidal activity was observed for the petroleum ether and alkaloidal extracts of the stem bark of Unonopsis buchtienii, the alkaloids and sterols isolated from these were studied. Of the alkaloids, liriodenine exhibited the highest activity against Leishmania major and L donovani (IC100 = 3.12 micrograms/mL). On the other hand, O-methylmoschatoline and the petroleum ether extract without alkaloids showed an interesting in vitro activity against Trypanosoma brucei with an IC100 of 6.25 micrograms/mL. The highest cytotoxic activities were found with the petroleum ether extracts without alkaloids and with all alkaloids isolated (IC50 < 9 micrograms/mL for Vero cell line).
  • Thumbnail Image
    Item type: Item ,
    Leishmanicidal and Trypanocidal activities of Acetogenins isolated fromAnnona glauca
    (Wiley, 1998) Anne-Isabelle Waechter; Gloria Yaluff; Alba Inchausti; Antonieta Rojas de Árias; Reynald Hocquemiller; André Cavé; Alain Fournet
    The dichloromethane extract of seeds of Annona glauca (Annonaceae) was active against three strains of Leishmania species. Nine known acetogenins were isolated and identified and then evaluated in vitro against Leishmania species and the bloodstream forms of Trypanosoma cruzi. Annonacin A and goniothalamicin showed activity against Leishmania, and glaucanisin, squamocin, annonacin A and annonacin against Trypanosoma cruzi reducing the parasites by 78%, 67%, 71% and 85%, respectively. Copyright © 1998 John Wiley & Sons, Ltd.