Browsing by Autor "B Khanna"

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EPIDEMIOLOGY OF <i>HELICOBACTER PYLORI</i> INFECTION IN RURAL BOLIVIAN CHILDREN:98
(Lippincott Williams & Wilkins, 1997) C Friedman; Robert Quick; B Khanna; A Salcido; N lihoshi; M Gironaz; O Ganzales; Lori Hutwagner; Robert V. Tauxe; Eric Mintz
Introduction: Helicobacter pylori (Hp) is acquired in childhood, causes gastritis, duodenal ulcers, and is linked to MALT lymphoma and gastric cancer. Studies suggest that infection is the cause of iron deficiency anemia in Alaska Natives and in Bangladeshi children. Consumption of contaminated water has been reported as a risk factor for Hp infection in South America, although exact routes of transmission are not defined. Objectives: We determined the seroprevalence and risk factors for Hp infection acquisition in rural Bolivian children, and if an association between Hp and anemia existed in this population. Methods: The Hp serostatus and hemoglobin levels of 1,392 (70%) children between 6 months and 9 years living in 17 villages were determined. Information on dietary practices, hygeine, and water handling were performed. Drinking sources were tested for fecal coliforms. Results: Overall, 44% of children were Hp seropositive, 49% seronegative, and 7% had indeterminate serostatus. Of 1,293 children with defined serostatus, seroprevalence increased from 7% in children aged 6-12 months to 59% in 4-year olds. Controlling for age and family clustering, drinking contaminated water was associated with Hp infection (p<0.05). Univariate analysis demonstrated consumption of premasticated food was significantly associated with Hp infection in infants 6 months to 1 year (p<0.05). Overall, 38% of children were anemic. Anemia status decreased from 77% in < 2 years to 17% in 9-year olds. Multivariate analysis demonstrated no association between Hp infection and anemia. Conclusions: Hp seroprevalence is high in rural Bolivian children and most children are infected by 5 years of life. Contaminated drinking water may be a risk factor for Hp infection which suggests that intervention in drinking water purity may decrease seroconversion rates. Although anemia is significant in this population, an association between Hp infection and anemia was not confirmed.
EPIDEMIOLOGY OF HELICOBACTER PYLORI INFECTION IN RURAL BOLIVIAN CHILDREN
(Lippincott Williams & Wilkins, 1997) C Friedman; Robert Quick; B Khanna; A Salcido; N lihoshi; M Gironaz; O Ganzales; Lori Hutwagner; Robert V. Tauxe; Eric Mintz
Introduction: Helicobacter pylori (Hp) is acquired in childhood, causes gastritis, duodenal ulcers, and is linked to MALT lymphoma and gastric cancer. Studies suggest that infection is the cause of iron deficiency anemia in Alaska Natives and in Bangladeshi children. Consumption of contaminated water has been reported as a risk factor for Hp infection in South America, although exact routes of transmission are not defined. Objectives: We determined the seroprevalence and risk factors for Hp infection acquisition in rural Bolivian children, and if an association between Hp and anemia existed in this population. Methods: The Hp serostatus and hemoglobin levels of 1,392 (70%) children between 6 months and 9 years living in 17 villages were determined. Information on dietary practices, hygeine, and water handling were performed. Drinking sources were tested for fecal coliforms. Results: Overall, 44% of children were Hp seropositive, 49% seronegative, and 7% had indeterminate serostatus. Of 1,293 children with defined serostatus, seroprevalence increased from 7% in children aged 6-12 months to 59% in 4-year olds. Controlling for age and family clustering, drinking contaminated water was associated with Hp infection (p<0.05). Univariate analysis demonstrated consumption of premasticated food was significantly associated with Hp infection in infants 6 months to 1 year (p<0.05). Overall, 38% of children were anemic. Anemia status decreased from 77% in < 2 years to 17% in 9-year olds. Multivariate analysis demonstrated no association between Hp infection and anemia. Conclusions: Hp seroprevalence is high in rural Bolivian children and most children are infected by 5 years of life. Contaminated drinking water may be a risk factor for Hp infection which suggests that intervention in drinking water purity may decrease seroconversion rates. Although anemia is significant in this population, an association between Hp infection and anemia was not confirmed.
HELICOBACTER PYLORI SERO-INCIDENCE IN A COHORT OF RURAL BOLIVIAN CHILDREN
(Lippincott Williams & Wilkins, 1998) C Friedman; Mike Glynn; Robert Quick; B Khanna; Naomi Iihoshi; Carmen Revollo; B. D. Gold
58 High seroprevalence rates for Helicobacter pylori (Hp) have been reported in developing countries; however, sero-incidence studies to determine age of initial acquisition and risk factors for seroconversion are lacking. We conducted two seroprevalence studies, 15 months apart, to determine the age-specific sero-incidence rate in a cohort of rural Bolivian children. In 8/96, we conducted a survey of 1,392 children between 6 months and 9 years old, living in 17 rural Bolivian villages, to determine Hp serostatus. In 11/97, we returned to the same villages to conduct a follow-up study. The 15 month age-specific sero-incidence was determined for a cohort of 333 children, 6 months and 6 years old, who either participated in both surveys and were seronegative in the first or were born during the follow-up period. Overall, 36% of 1040 children surveyed in the follow-up study were seropositive, 52% were seronegative, and 12% had indeterminate serostatus. Of 918 children with a definitive Hp serostatus, seroprevalence increased from 4% in children aged 6-11 months to 61% in 6-year olds. In the cohort of 333 children, 64 (19%) seroconverted during the 15 month follow-up period. 15-month sero-incidence rates are summarized in the table below: The largest increase in sero-incidence occurred in children between ages 2 and 3 years old. Further analysis of risk factors for Hp seroconversion (i.e., infection acquisition) focusing on this age group is ongoing.TABLE
<i>HELICOBACTER PYLORI</i> SERO‐INCIDENCE IN A COHORT OF RURAL BOLIVIAN CHILDREN
(Lippincott Williams & Wilkins, 1998) C Friedman; Mike Glynn; Robert Quick; B Khanna; Naomi Iihoshi; Carmen Revollo; B. D. Gold