Browsing by Autor "Benjamin C. Trumble"

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Arterial Stiffness in Heart‐Healthy Indigenous Tsimane Forager‐Horticulturalists
(Wiley, 2025) Tianyu Cao; Edhitt Cortez Linares; Raúl Quispe Gutierrez; Daniel Eid Rodríguez; Juana Bani Cuata; Michael I. Miyamoto; Christopher von Rueden; Daniel K. Cummings; Paul L. Hooper; Benjamin C. Trumble
Tsimane forager-farmers of the Bolivian Amazon demonstrate substantially lower arterial stiffness throughout adulthood than more urbanized and sedentary populations, and the differences are only partially explained by conventional cardiometabolic risk factors.
Coronary atherosclerosis in indigenous South American Tsimane: a cross-sectional cohort study
(Elsevier BV, 2017) Hillard Kaplan; Randall C. Thompson; Benjamin C. Trumble; L. Samüel Wann; Adel H. Allam; Bret Beheim; Bruno Frøhlich; M. Linda Sutherland; James D. Sutherland; Jonathan Stieglitz
Health costs of reproduction are minimal despite high fertility, mortality and subsistence lifestyle
(Nature Portfolio, 2016) Michael Gurven; Megan Costa; Benjamin C. Trumble; Jonathan Stieglitz; Bret Beheim; Daniel Eid Rodríguez; Paul L. Hooper; Hillard Kaplan
High prevalence of sternal foramina in indigenous Bolivians compared to Midwest Americans and indigenous North Americans (sternal foramina in indigenous Bolivians)
(Springer Science+Business Media, 2021) Benjamin D. Gans; Angela D. Neunuebel; Leah J. Umbarger; Benjamin C. Trumble; Daniel K. Cummings; L. Samüel Wann; Kyle R. Lehenbauer; Ashna Mahadev; Daniel Rodríguez; David E. Michalik
Apolipoprotein- ε 4 is associated with higher fecundity in a natural fertility population
(American Association for the Advancement of Science, 2023) Benjamin C. Trumble; Mia Charifson; Thomas S. Kraft; Angela R. García; Daniel K. Cummings; Paul L. Hooper; Amanda J. Lea; Daniel Eid Rodríguez; Stephanie V. Koebele; Kenneth H. Buetow
In many populations, the apolipoprotein-ε4 (APOE-ε4) allele increases the risk for several chronic diseases of aging, including dementia and cardiovascular disease; despite these harmful effects at later ages, the APOE-ε4 allele remains prevalent. We assess the impact of APOE-ε4 on fertility and its proximate determinants (age at first reproduction, interbirth interval) among the Tsimane, a natural fertility population of forager-horticulturalists. Among 795 women aged 13 to 90 (20% APOE-ε4 carriers), those with at least one APOE-ε4 allele had 0.3 to 0.5 more children than (ε3/ε3) homozygotes, while those with two APOE-ε4 alleles gave birth to 1.4 to 2.1 more children. APOE-ε4 carriers achieve higher fertility by beginning reproduction 0.8 years earlier and having a 0.23-year shorter interbirth interval. Our findings add to a growing body of literature suggesting a need for studies of populations living in ancestrally relevant environments to assess how alleles that are deleterious in sedentary urban environments may have been maintained by selection throughout human evolutionary history.
Increases in regional brain volume across two native South American male populations
(Springer International Publishing, 2024) Nikhil N. Chaudhari; Phoebe Imms; Nahian F. Chowdhury; Margaret Gatz; Benjamin C. Trumble; Wendy J. Mack; Emma Law; M. Linda Sutherland; James D. Sutherland; Christopher J. Rowan
Indirect genetic effects among neighbors promote cooperation and accelerate adaptation in a small-scale human society
(American Association for the Advancement of Science, 2025) Jordan S. Martin; Bret Beheim; Michael Gurven; Hillard Kaplan; Jonathan Stieglitz; Benjamin C. Trumble; Paul L. Hooper; Daniel K. Cummings; Daniel Eid Rodríguez; Adrian V. Jaeggi
Explaining the rapid evolution of human cooperation and its role in our species' biodemographic success remains a major evolutionary puzzle. To address this challenge, we tested a social drive hypothesis, which predicts that social plasticity and social selection in human groups cause indirect genetic effects that accelerate the adaptation of fitness, promoting population growth via feedback between the environmental causes and evolutionary consequences of cooperation. Using Bayesian multilevel models to analyze fertility data from a small-scale society, we demonstrate that density- and frequency-dependent indirect genetic effects on fitness promote the evolution of cooperation among neighboring women, increasing the rate of contemporary adaptation by ~5×. Our results show how interactions between the genetic and socioecological processes shaping cooperation in reproduction can drive rapid growth and social evolution in human populations.
Not All Stress Is the Same: Variable Associations Between Psychosocial Stressors and Urinary Cortisol Rhythms in a Small‐Scale Subsistence Society
(Wiley, 2026) Dominik C. Jud; Valerie Baettig; Abigail E. Colby; Charlotte Debras; Camila Scaff; Benjamin C. Trumble; Lorin Hutchings; M. Baumgarten; Arnulfo Cary Ista; Adrian V. Jaeggi
While many of these associations had high statistical uncertainty due to wide posterior distributions, the results overall emphasize complex relationships between perceived stressors and diurnal cortisol rhythms among a small-scale subsistence-based society. Future work employing longitudinal designs and higher-resolution sampling will be needed to clarify these trends.
Poor Oral Health Is Associated With Inflammation, Aortic Valve Calcification, and Brain Volume Among Forager-Farmers
(Oxford University Press, 2024) Benjamin C. Trumble; Matthew Schwartz; Andrew T. Ozga; Gary T. Schwartz; Christopher M. Stojanowski; Carrie L. Jenkins; Thomas S. Kraft; Angela R. García; Daniel K. Cummings; Paul L. Hooper
Poor oral health is associated with cardiovascular disease and dementia. Potential pathways include sepsis from oral bacteria, systemic inflammation, and nutritional deficiencies. However, in post-industrialized populations, links between oral health and chronic disease may be confounded because the lower socioeconomic exposome (poor diet, pollution, and low physical activity) often entails insufficient dental care. We assessed tooth loss, caries, and damaged teeth, in relation to cardiovascular and brain aging among the Tsimane, a subsistence population living a relatively traditional forager-horticulturalist lifestyle with poor dental health, but minimal cardiovascular disease and dementia. Dental health was assessed by a physician in 739 participants aged 40-92 years with cardiac and brain health measured by chest computed tomography (CT; n = 728) and brain CT (n = 605). A subset of 356 individuals aged 60+ were also assessed for dementia and mild cognitive impairment (n = 33 impaired). Tooth loss was highly prevalent, with 2.2 teeth lost per decade and a 2-fold greater loss in women. The number of teeth with exposed pulp was associated with higher inflammation, as measured by cytokine levels and white blood cell counts, and lower body mass index. Coronary artery calcium and thoracic aortic calcium were not associated with tooth loss or damaged teeth. However, aortic valve calcification and brain tissue loss were higher in those who had more teeth with exposed pulp. Overall, these results suggest that dental health is associated with indicators of chronic diseases in the absence of typical confounds, even in a population with low cardiovascular and dementia risk factors.
Prehistoric Global Migration of Vanishing Gut Microbes With Humans
(2025) Matthew M. Carter; Zhiru Liu; Matthew R. Olm; Mélanie Martin; Daniel D. Sprockett; Benjamin C. Trumble; Hillard Kaplan; Jonathan Stieglitz; Daniel Eid Rodríguez; David A. Relman
Abstract The gut microbiome is crucial for health and greatly affected by lifestyle. Many microbes common in non-industrialized populations are disappearing or extinct in industrialized populations. Understanding which microbes have been long-term residents of the human gut, and may have co-evolved with humans, has implications for the importance of microbial biodiversity loss for health. However, the genetic complexities of microbial evolution and the plasticity of gut microbiome composition have made it challenging to define these long-term associations. Here, we performed deep metagenomic sequencing of the Tsimane horticulturalists of Bolivia and compared their gut microbiomes with the Hadza hunter-gatherers of Tanzania. These two populations, whose ancestors were separated for tens of thousands of years, share 1,231 microbial species, most of which are absent in industrialized populations. Population genetic analyses in 636 of these shared species revealed patterns of microbial divergence and gene flow consistent with prehistoric human co-migration, with estimated split times that approximately align with human migration out of Africa and into the Americas. Our findings indicate that a diverse gut microbiome co-migrated with humans around the globe, persisting over millennia. However, many of these species are now vanishing in industrialized populations, and the consequences for human health remain uncertain.
Subjective well-being across the life course among non-industrialized populations
(American Association for the Advancement of Science, 2024) Michael Gurven; Yoann Buoro; Daniel Eid Rodríguez; M. Katherine Sayre; Benjamin C. Trumble; Aili Pyhälä; Hillard Kaplan; Arild Angelsen; Jonathan Stieglitz; Victòria Reyes-García
Subjective well-being (SWB) is often described as being U-shaped over adulthood, declining to a midlife slump and then improving thereafter. Improved SWB in later adulthood has been considered a paradox given age-related declines in health and social losses. While SWB has mostly been studied in high-income countries, it remains largely unexplored in rural subsistence populations lacking formal institutions that reliably promote social welfare. Here, we evaluate the age profile of SWB among three small-scale subsistence societies (n = 468; study 1), forest users from 23 low-income countries (n = 6987; study 2), and Tsimane' horticulturalists (n = 1872; study 3). Across multiple specifications, we find variability in SWB age profiles. In some cases, we find no age-related differences in SWB or even inverted U-shapes. Adjusting for confounders reduces observed age effects. Our findings highlight variability in average well-being trajectories over the life course. Ensuring successful aging will require a greater focus on cultural and socioecological determinants of individual trajectories.
Testosterone is positively associated with coronary artery calcium in a low cardiovascular disease risk population
(University of Oxford, 2023) Benjamin C. Trumble; Jacob D. Negrey; Stephanie V. Koebele; Randall C. Thompson; L. Samüel Wann; Adel H. Allam; Bret Beheim; M. Linda Sutherland; James D. Sutherland; Daniel Eid Rodríguez
Among Tsimane, testosterone is positively associated with coronary artery calcium despite generally low normal testosterone levels, minimal atherosclerosis and rare cardiovascular disease (CVD) events. Associations between low testosterone and CVD events in industrialized populations are likely confounded by obesity and other lifestyle factors.
Voluntary collective isolation as a best response to COVID-19 for indigenous populations? A case study and protocol from the Bolivian Amazon
(Elsevier BV, 2020) Hillard Kaplan; Benjamin C. Trumble; Jonathan Stieglitz; Roberta Mendez Mamany; Maguin Gutierrez Cayuba; Leonardina Maito Moye; Sarah Alami; Thomas S. Kraft; Raúl Quispe Gutierrez; Juan Copajira Adrian