Browsing by Autor "Bernard Richard"

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    Activité antipaludique du n-hentriacontanol isolé de<i>Cuatresia</i>sp (Solanaceae)
    (EDP Sciences, 1992) Eric Deharo; Michel Sauvain; Costanzo Moretti; Bernard Richard; E. Ruiz; Georges Massiot
    L’activité antipaludique de l’alcool gras n-hentriacontanol isolé d’une Solanacée bolivienne Cuatresia sp. est appréciée in vivo, par le test classique du traitement de 4 jours, sur Plasmodium berghei et P. vinckei chez la souris. Le produit réduit nettement la virulence de l’infection à P. vinckei. Le n-hentriacontanol appartient à une nouvelle classe de composés naturels antimalariques exploitables en thérapeutique.
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    Alkaloids from<i>Aspidosperma</i>Species from Bolivia
    (Thieme Medical Publishers (Germany), 1996) A.-C. Mitaine; K. Mesbah; Bernard Richard; Christian Petermann; S. Arrazola; Christian Moretti; Monique Zèches-Hanrot; Louisette Le Men‐Olivier
    Two Bolivian Aspidosperma species were investigated. The seed and stem bark of Aspidosperma macrocarpon Mart. contain six known alkaloids: (-)-vincadifformine, ervinceine, kopsanone, kopsinine, kopsanol in the seed, and kopsanone, kopsinine, kopsanol, 18-epikopsanol in the stem bark. The stem bark of Aspidosperma pyrifolium Mart. contains eleven known alkaloids: (-)-vincadifformine, O-demethylpalosine, haplocine, N-formylaspidospermidine, vallesine, demethoxyaspidospermine, palosine, (-)-aspidospermine, aspidospermidine, akuammicine, tubotaiwine, beside the two new bases dehydroxyhaplocidine and 10-methoxyaspidospermidine.
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    Antimalarial Activity of Alkaloids from Pogonopus tubulosus
    (Wiley, 1996) Michel Sauvain; Christian Moretti; José-Antonio Bravo; Jorgia Callapa; Victoria Muñoz; E. Ruiz; Bernard Richard; Louisette Le Men‐Olivier
    The antimalarial activity of the Bolivian medicinal plant Pogonopus tubulosus (D.C.) Schumann was evaluated by in vitro testing on trophozoite stages of resistant and sensitive strains of Plasmodium falciparum and by in vivo tests on P. berghei and P. vinckei petteri in mice. The bark of this medicinal plant yielded three alkaloids: tubulosine, psychotrine, cephaeline. Tubulosine showed an interesting activity in vitro with an IC50 of 0.006 μg/mL against the sensitive strain of P. falciparum and an IC50 of 0.011 μg/mL against the resistant strain of P. falciparum. This compound had good in vivo antimalarial activity with an ED50 of 0.05 mg/kg/day on P. vinckei petteri strain and an ED50 of 0.45 mg/kg/day on P. berghei.
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    Antimalarial Activity of Alkaloids fromPogonopus tubulosus
    (Wiley, 1996) Michel Sauvain; Christian Moretti; José-Antonio Bravo; Jorgia Callapa; Victoria Muñoz; E. Ruiz; Bernard Richard; Louisette Le Men‐Olivier
    The antimalarial activity of the Bolivian medicinal plant Pogonopus tubulosus (D.C.) Schumann was evaluated by in vitro testing on trophozoite stages of resistant and sensitive strains of Plasmodium falciparum and by in vivo tests on P. berghei and P. vinckei petteri in mice. The bark of this medicinal plant yielded three alkaloids: tubulosine, psychotrine, cephaeline. Tubulosine showed an interesting activity in vitro with an IC50 of 0.006 μg/mL against the sensitive strain of P. falciparum and an IC50 of 0.011 μg/mL against the resistant strain of P. falciparum. This compound had good in vivo antimalarial activity with an ED50 of 0.05 mg/kg/day on P. vinckei petteri strain and an ED50 of 0.45 mg/kg/day on P. berghei.
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    Isolation of Bis-Indole Alkaloids with Antileishmanial and Antibacterial Activities from<i>Perschiera van heurkii</i>(Syn.<i>Tabernaemontana van heurkii</i>)
    (Thieme Medical Publishers (Germany), 1994) Verónica Francisca Loewe Muñoz; C. Moretti; Michel Sauvain; C. Caron; Andrea Porzel; Georges Massiot; Bernard Richard; Louisette Le Men‐Olivier
    Extracts from leaves and stem bark of Peschiera van heurkii (Muell. Arg.) L. Allorge (syn. Tabernaemontana van heurkii Muell. Arg., Apocynaceae) have been assayed for antileishmanial and antibacterial activities. The activities were concentrated in the alkaloid fractions which yielded 20 indole and bisindole alkaloids. The strongest leishmanicidal and antibacterial activities were observed with the dimeric alkaloids conodurine (1), N-demethylconodurine (= gabunine) (2), and conoduramine (3). Weak toxicity towards macrophage host cells and strong activity against the intracellular amastigote form of Leishmania were observed for compounds 1 and 2. In vivo, 1 was less active than glucantime (= N-methylglucamine antimonate), the drug of reference, while 2 was devoid of activity at 100 mg/kg.