Browsing by Autor "Brett M. Forshey"

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    Arboviral Etiologies of Acute Febrile Illnesses in Western South America, 2000–2007
    (Public Library of Science, 2010) Brett M. Forshey; Carolina Guevara; V. Alberto Laguna-Torres; Manuel Céspedes; Jorge Vargas; Alberto Gianella; Efraín Vallejo; César Madrid; Nicolás Aguayo; Eduardo Gotuzzo
    Our data provide a better understanding of the geographic range of arboviruses in South America and highlight the diversity of pathogens in circulation. These arboviruses are currently significant causes of human illness in endemic regions but also have potential for further expansion. Our data provide a basis for analyzing changes in their ecology and epidemiology.
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    Novel Strain of Andes Virus Associated with Fatal Human Infection, Central Bolivia
    (Centers for Disease Control and Prevention, 2012) Cristhopher D. Cruz; Brett M. Forshey; Efraín Vallejo; Roberto Agudo; Jorge Vargas; David L. Blazes; Carolina Guevara; V. Alberto Laguna-Torres; Eric S. Halsey; Tadeusz J. Kochel
    To better describe the genetic diversity of hantaviruses associated with human illness in South America, we screened blood samples from febrile patients in Chapare Province in central Bolivia during 2008-2009 for recent hantavirus infection. Hantavirus RNA was detected in 3 patients, including 1 who died. Partial RNA sequences of small and medium segments from the 3 patients were most closely related to Andes virus lineages but distinct (<90% nt identity) from reported strains. A survey for IgG against hantaviruses among residents of Chapare Province indicated that 12.2% of the population had past exposure to >1 hantaviruses; the highest prevalence was among agricultural workers. Because of the high level of human exposure to hantavirus strains and the severity of resulting disease, additional studies are warranted to determine the reservoirs, ecologic range, and public health effect of this novel strain of hantavirus.