Browsing by Autor "C. David"

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Evidence for a Major Gene Controlling Susceptibility to Tegumentary Leishmaniasis in a Recently Exposed Bolivian Population
(Elsevier BV, 1997) Alexandre Alcaïs; Laurent Abel; C. David; M Torrez; Philippe Flandre; Jean-Pierre Dedet
Fifteen years of cutaneous and mucocutaneous leishmaniasis in Bolivia: a retrospective study
(Oxford University Press, 1993) C. David; L. Dimier-David; Fernando Vargas; M Torrez; Jean-Pierre Dedet
This paper present the results of a retrospective study of cases of cutaneous and mucocutaneous leishmaniasis in Bolivia between 1975 and 1991. The total number of cases reported was 4058, 739 of which were mucous. Three different areas of endemic leishmaniasis are defined in Bolivia.
[Histopathology of mucocutaneous leishmaniasis caused by Leishmania (Vianna) braziliensis].
(National Institutes of Health, 1994) L. Dimier-David; P Ravisse; R Bustillos; F Rollano; F. Mallea; C. David; Philippe Lyèvre; L Valda; Jean-Pierre Dedet
A histopathological study of mucocutaneous leishmaniasis due to Leishmania (Viannia) braziliensis was carried out on 28 cutaneous and 114 mucosal biopsies, taken from Bolivian and Peruvian patients. This study showed similar histopathological findings in cutaneous and mucosal lesions. The cutaneous biopsies showed a strong epidermal hyperplasia occasionnally budding in the dermis. In the ulcerative area, the epidermis was totally necrosed and replaced by a fibrino-leucocytic edge. In the dermis, histio-lympho-plasmocytic infiltration was constantly found. The histiocytes often gathered in follicles sometimes with diffuse fibrosis. The parasites were encountered in 28.6 p. 100 of the biopsies. Whatever the mucosa concerned (i.e. nasal, palatal or lingual), the mucosal lesion was not different from the cutaneous lesion. The malpighian epithelium is either absent or the seat of a pseudo-epitheliomatous hyperplasia. Major histio-lympho-plasmocytic infiltration was found and extended through the depth of the lamina propria. Suppurative and fibrinoid necroses coexisted superficially and sometimes penetrated in depth. The parasites were found in about 30 p. 100 of the cases.
Isoenzyme characterization of Leishmania braziliensis braziliensis isolates obtained from Bolivian and Peruvian patients
(Oxford University Press, 1992) Susana Revollo; L. Dimier-David; C. David; Philippe Lyèvre; Clara Camacho; Jean-Pierre Dedet
Thirty-four Leishmania isolates obtained from Bolivian and Peruvian patients infected with mucocutaneous leishmaniasis were characterized by isoenzyme electrophoresis using 10 enzymatic markers; all belonged to the subspecies L.b. braziliensis. Three isolates showed marked variation compared with the reference strain with respect to 5 or 6 enzymes. These variant isolates originated from patients with forms of the disease which were unresponsive to treatment.
Rural campaign to diagnose and treat mucocutaneous leishmaniasis in Bolivia.
(National Institutes of Health, 1995) Jean-Pierre Dedet; R Melogno; Fernando Cárdenas; L Valda; C. David; Victoria Gallardo; M Torrez; L. Dimier-David; Philippe Lyèvre; M E Villareal
Mucocutaneous leishmaniasis (MCL) is endemic in the tropical Amazonian lowlands of Bolivia, an area that regularly receives influxes of migratory populations. In these new agricultural development areas, a campaign to diagnose and treat the disease was carried out between 1989 and 1992, in order to provide direct access to MCL treatment in the endemic areas at a standard equivalent to that offered in the urban centres in Bolivia. The campaign led to the creation of decentralized local centres for diagnosis and treatment of the disease. A campaign to inform the population about leishmaniasis was also undertaken and courses were run to educate medical and paramedical personnel. As a result of the campaign, 3285 cases of leishmaniasis were diagnosed, including 2152 cutaneous and 326 mucosal forms. Also, a total of 1888 cases were treated, 1677 of which cutaneous and 211, mucosal.