Browsing by Autor "Carlos Emilio Restrepo"

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    Glioblastoma with leptomeningeal dissemination, symptomatic intramedullary extension, and bone marrow metastases
    (2024) Javier A. Jacobo; Jorge Aristizabal; Nicolle Wagner-Gutiérrez; Alejandro Patiño; Carlos Emilio Restrepo; Diego Pineda; Iván Bobadilla; Jencet Montaño; Óscar Arrieta; Andrés F. Cardona
    Glioblastoma (GB) is the most common primary Central Nervous System (CNS) tumor and the most malignant of the glial neoplasm; despite its aggressive behavior, metastases are rarely seen. The most common form of metastasis is leptomeningeal dissemination, which can be present in almost 15-35% of the patients, though symptomatic spinal cord invasion is far less common (1.6%), and extra neural metastases are an atypical event (0.2-3%). Here, we present the case of a 36-year-old patient with primary GB who developed leptomeningeal dissemination, intramedullary extension, and multiple extra neural metastases, including bone marrow, vertebra, skull, and liver, without primary site recurrence.