Browsing by Autor "Carolina Torres"

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    An unwanted association: the threat to papaya crops by a novel potexvirus in northwest Argentina
    (2022) Dariel Cabrera Mederos; Humberto Debat; Carolina Torres; Orelvis Portal; Margarita Jaramillo Zapata; Verónica Trucco; Ceferino Rene Flores; Claudio Ortiz; Alejandra Badaracco; Luis Acuña
    Abstract An emerging virus isolated from papaya ( Carica papaya ) crops in northwestern (NW) Argentina was sequenced and characterized using next-generation sequencing. The resulting genome is 6,667-nt long and encodes five open reading frames in an arrangement typical of other potexviruses. This virus appears to be a novel member within the genus Potexvirus . Blast analysis of RNA-dependent RNA polymerase (RdRp) and coat protein (CP) genes showed the highest amino acid sequence identity (67% and 71%, respectively) with pitaya virus X. Based on nucleotide sequence similarity and phylogenetic analysis, the name papaya virus X is proposed for this newly characterized potexvirus that was mechanically transmitted to papaya plants causing chlorotic patches and severe mosaic symptoms. RT-PCR based detection of papaya virus X (PapVX) revealed that it is widely present in papaya crops from NW Argentina. The prevalence of PapVX, which seems to be restricted to the NW region of Argentina, and the fact that it has only been detected in this region could be associated with a recent emergence or adaptation of this virus to papaya in NW Argentina.
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    Genetic polymorphism of <i>Trypanosoma cruzi</i> bloodstream populations in adult chronic indeterminate Chagas disease patients from the E1224 clinical trial
    (Oxford University Press, 2021) Juan Carlos Ramı́rez; Gonzalo R. Acevedo; Carolina Torres; Rudy Parrado; Anabelle de la Barra; Sandro Villarroel; Lineth García; Joaquím Gascón; Lourdes Ortiz; Faustino Torrico
    Genetic variability of T. cruzi bloodstream populations during post-treatment follow-up did not differ from that observed during chronic infection in the absence of treatment, suggesting that there were no selection events of E1224-resistant parasite populations. This is the first report documenting the genetic polymorphism of natural T. cruzi populations in chronic patients in the context of clinical trials with trypanocidal drugs.