Browsing by Autor "Catherine Lavaud"

Now showing 1 - 5 of 5

4-Quinolinone alkaloids from Dictyoloma peruviana
(Elsevier BV, 1995) Catherine Lavaud; Georges Massiot; Carmen Vásquez; Christian Moretti; Michel Sauvain; Luisa Balderrama
A Novel Antiprotozoal Aminosteroid from Saracha punctata
(American Chemical Society, 1998) Christian Moretti; Michel Sauvain; Catherine Lavaud; Georges Massiot; José A. Bravo; Verónica Francisca Loewe Muñoz
A new aminosteroid, 3beta-amino-22,26-epiminocholest-5-ene named sarachine (1), and two known flavonoids, eriodictyol (2) and 7-O-beta-D-glucopyranosyl-eriodictyol (3), were isolated from the leaves of Saracha punctata. The alkaloid was found to inhibit the growth of Leishmania braziliensis promastigotes (100% at 25 microM) and of Trypanosoma cruzi epimastigotes in culture (50% at 25 microM) and showed a strong in vitro antiplasmodial activity with an IC50 of 25 nM.
Bioactive phenolic glycosides from Amburana cearensis
(Elsevier BV, 1999) José A. Bravo B.; Michel Sauvain; Alberto Gimenez T.; Victoria Muñoz O; Jorgia Callapa; Louisette Le Men‐Olivier; Georges Massiot; Catherine Lavaud
Triterpene saponins fromMyrsine pellucida
(Elsevier BV, 1994) Catherine Lavaud; Georges Massiot; Jose ́Bravo Barrera; Christian Moretti; Louisette Le Men‐Olivier
Trypanocidal Withanolides and Withanolide Glycosides from Dunalia brachyacantha
(American Chemical Society, 2001) José A. Bravo B.; Michel Sauvain; Alberto Gimenez T.; Elfride Balanza; Laurent Sérani; Olivier Laprévôte; Georges Massiot; Catherine Lavaud
Two new withanolide glycosides, (20R,22R)-O-(3)-alpha-L-rhamnopyranosyl(1-->4)-beta-D-glucopyranosyl-1 alpha,12 beta-diacetoxy-20-hydroxywitha-5,24-dienolide (3) and (20R,22R)-O-(3)-beta-D-xylopyranosyl(1-->3)-[beta-D-xylopyranosyl(1-->4)]-beta-D-glucopyranosyl-1 alpha-acetoxy-12 beta,20-dihydroxywitha-5,24-dienolide (4), were isolated from the leaves and root of Dunalia brachyacantha. Their aglycones, (20R,22R)-1 alpha,12 beta-diacetoxy-3 beta,20-dihydroxywitha-5,24-dienolide (or 1 alpha,12 beta-diacetyldunawithagenine) and (20R,22R)-1 alpha-acetoxy-3 beta,12 beta,20-trihydroxywitha-5,24-dienolide (or 1 alpha-acetyl-12 beta-hydroxydunawithagenine), are novel. The known 18-acetoxywithanolide D (1) and 18-acetoxy-5,6-deoxy-5-withenolide D (2) were also isolated from the leaves. These last two compounds were shown to be responsible for the trypanocidal, leishmanicidal, and bactericidal activities manifested by the crude ethanolic extract. The structures were deduced from spectroscopic data and on the basis of chemical evidence.