Browsing by Autor "Christian Lindh"

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Arsenic exposure and biomarkers for oxidative stress and telomere length in indigenous populations in Bolivia
(Elsevier BV, 2022) Jessica De Loma; Annette M. Krais; Christian Lindh; Josué Mamani; Noemí Tirado; Jacques Gardon; Karin Bröberg
Correction to: Pesticide exposure among Bolivian farmers: associations between worker protection and exposure biomarkers
(Springer Nature, 2019) Jessika Barrón Cuenca; Noemí Tirado; Max Vikström; Christian Lindh; Ulla Stenius; Karin Leander; Marika Berglund; Kristian Dreij
Correction: Pesticide exposure among Bolivian farmers: associations between worker protection and exposure biomarkers
(Springer Nature, 2021) Jessika Barrón Cuenca; Noemí Tirado; Max Vikström; Christian Lindh; Ulla Stenius; Karin Leander; Marika Berglund; Kristian Dreij
Genotoxic damage in a Bolivian agricultural population exposed to a mixture of pesticides
(Wolters Kluwer, 2019) John H. Barron; Noemí Tirado; J. Barral; Christian Lindh; Ulla Stenius; Marika Berglund; Kristian Dreij
TPS 792: Occupational health 2, Exhibition Hall, Ground floor, August 27, 2019, 3:00 PM - 4:30 PM Pesticides are well-known chemicals that can increase the risk to develop cancer by induction of DNA damage and oxidative stress, especially in populations with chronic exposure. Bolivian farmers have been increasing their use of pesticides during the last decades to increase their production and economy. Chronic exposure to these chemicals, their combined effects and genetic polymorphisms can increase the risk of genotoxic damage, mutagenicity and development of chronic diseases. A cross-sectional study in 297 volunteers from three different Bolivian agricultural communities was conducted. Exposure and handling of pesticides were assessed by a questionnaire and urinary pesticide metabolite analysis. Genotoxic effects were evaluated in collected blood samples by Micronucleus and Comet assay. Frequency of glutathione transferase (GST) null genotypes (GSTM1 and GSTT1) was determined to evaluate the impact on DNA damage levels. The results showed that only 17% of the farmers used recommended protection equipment. In agreement, they were highly exposed to chlorpyrifos, pyrethroids and 2,4-D, and men generally more highly compared to women. Higher frequency of micronuclei (MN) was found in women compared to men (4.52 vs 3.55, p<0.05). Farmers active >8 years had higher frequency of MN compared to farmers active <8 years (4.23 vs 2.94, p<0.05). Surprisingly, a null GST genotype (GSTM1 and GSTT1: 84% and 24% null, respectively) was associated with lower levels of DNA damage. High levels of exposure to tebuconazole, 2,4-D or cyfluthrin was associated with high levels of DNA strand breaks (p<0.05-0.01). After adjustment for confounding factors (e.g. gender, age, GST genotype), a significant increased risk of DNA strand breaks was found for exposure to 2,4-D (OR=1.9, CI=1.0-3.8, p=0.049). In conclusion, agricultural Bolivian population, especially men are highly exposed to mixtures of pesticides causing genotoxic effects in lymphocytes and which constitutes an increased risk of developing cancer in the future.
Pesticide exposure among Bolivian farmers: associations between worker protection and exposure biomarkers
(Springer Nature, 2019) Jessika Barrón Cuenca; Noemí Tirado; Max Vikström; Christian Lindh; Ulla Stenius; Karin Leander; Marika Berglund; Kristian Dreij
The use of pesticides has increased during the past decades, also increasing the risk of exposure to toxic pesticides that can cause detrimental health effects in the future. This is of special concern among farmers in low-to-middle-income countries that may lack proper training in the safe use of these chemicals. To assess the situation in Bolivia a cross-sectional study in three agricultural communities was performed (n = 297). Handling, use of personal protective equipment (PPE) and pesticide exposure were assessed by a questionnaire and measurements of urinary pesticide metabolites (UPMs). Results showed that methamidophos (65%) and paraquat (52%) were the most commonly used pesticides and that 75% of the farmers combined several pesticides while spraying. Notably, only 17% of the farmers used recommended PPEs while 84% reported to have experienced symptoms of acute pesticide poisoning after spraying. UPM measurements indicated high levels of exposure to chlorpyrifos, pyrethroids and 2,4D and that men generally were more highly exposed compared to women. Our study demonstrates that farmers who are better at following recommendations for pesticide handling and use of PPE had a significantly lower risk of having high UPM levels of most measured pesticides. Our results thus confirm the need of proper training of farmers in low-to-middle-income countries in proper protection and pesticide handling in order to reduce exposure levels and health problems.
Pesticide exposure and genotoxic effects among Bolivian farmers: A cross-sectional study
(Elsevier BV, 2017) Jessika Barrón Cuenca; Noemí Tirado; Christian Lindh; Marika Berglund; Kristian Dreij