Browsing by Autor "Christian Moretti"

Now showing 1 - 10 of 10

4-Quinolinone alkaloids from Dictyoloma peruviana
(Elsevier BV, 1995) Catherine Lavaud; Georges Massiot; Carmen Vásquez; Christian Moretti; Michel Sauvain; Luisa Balderrama
A Novel Antiprotozoal Aminosteroid from Saracha punctata
(American Chemical Society, 1998) Christian Moretti; Michel Sauvain; Catherine Lavaud; Georges Massiot; José A. Bravo; Verónica Francisca Loewe Muñoz
A new aminosteroid, 3beta-amino-22,26-epiminocholest-5-ene named sarachine (1), and two known flavonoids, eriodictyol (2) and 7-O-beta-D-glucopyranosyl-eriodictyol (3), were isolated from the leaves of Saracha punctata. The alkaloid was found to inhibit the growth of Leishmania braziliensis promastigotes (100% at 25 microM) and of Trypanosoma cruzi epimastigotes in culture (50% at 25 microM) and showed a strong in vitro antiplasmodial activity with an IC50 of 25 nM.
A study of the chemical composition of Erythroxylum coca var. coca leaves collected in two ecological regions of Bolivia
(Elsevier BV, 1997) Michel Sauvain; C Rerat; Christian Moretti; E. Saravia; S. Arrazola; Eusebio Dohijo Gutiérrez; Ana María Lema; Verónica Francisca Loewe Muñoz
Alkaloids fromAspidospermaSpecies from Bolivia
(Thieme Medical Publishers (Germany), 1996) A.-C. Mitaine; K. Mesbah; Bernard Richard; Christian Petermann; S. Arrazola; Christian Moretti; Monique Zèches-Hanrot; Louisette Le Men‐Olivier
Two Bolivian Aspidosperma species were investigated. The seed and stem bark of Aspidosperma macrocarpon Mart. contain six known alkaloids: (-)-vincadifformine, ervinceine, kopsanone, kopsinine, kopsanol in the seed, and kopsanone, kopsinine, kopsanol, 18-epikopsanol in the stem bark. The stem bark of Aspidosperma pyrifolium Mart. contains eleven known alkaloids: (-)-vincadifformine, O-demethylpalosine, haplocine, N-formylaspidospermidine, vallesine, demethoxyaspidospermine, palosine, (-)-aspidospermine, aspidospermidine, akuammicine, tubotaiwine, beside the two new bases dehydroxyhaplocidine and 10-methoxyaspidospermidine.
Antimalarial Activity of Alkaloids from Pogonopus tubulosus
(Wiley, 1996) Michel Sauvain; Christian Moretti; José-Antonio Bravo; Jorgia Callapa; Victoria Muñoz; E. Ruiz; Bernard Richard; Louisette Le Men‐Olivier
The antimalarial activity of the Bolivian medicinal plant Pogonopus tubulosus (D.C.) Schumann was evaluated by in vitro testing on trophozoite stages of resistant and sensitive strains of Plasmodium falciparum and by in vivo tests on P. berghei and P. vinckei petteri in mice. The bark of this medicinal plant yielded three alkaloids: tubulosine, psychotrine, cephaeline. Tubulosine showed an interesting activity in vitro with an IC50 of 0.006 μg/mL against the sensitive strain of P. falciparum and an IC50 of 0.011 μg/mL against the resistant strain of P. falciparum. This compound had good in vivo antimalarial activity with an ED50 of 0.05 mg/kg/day on P. vinckei petteri strain and an ED50 of 0.45 mg/kg/day on P. berghei.
Antimalarial Activity of Alkaloids fromPogonopus tubulosus
(Wiley, 1996) Michel Sauvain; Christian Moretti; José-Antonio Bravo; Jorgia Callapa; Victoria Muñoz; E. Ruiz; Bernard Richard; Louisette Le Men‐Olivier
The antimalarial activity of the Bolivian medicinal plant Pogonopus tubulosus (D.C.) Schumann was evaluated by in vitro testing on trophozoite stages of resistant and sensitive strains of Plasmodium falciparum and by in vivo tests on P. berghei and P. vinckei petteri in mice. The bark of this medicinal plant yielded three alkaloids: tubulosine, psychotrine, cephaeline. Tubulosine showed an interesting activity in vitro with an IC50 of 0.006 μg/mL against the sensitive strain of P. falciparum and an IC50 of 0.011 μg/mL against the resistant strain of P. falciparum. This compound had good in vivo antimalarial activity with an ED50 of 0.05 mg/kg/day on P. vinckei petteri strain and an ED50 of 0.45 mg/kg/day on P. berghei.
Antimalarial activity of cedronin
(Elsevier BV, 1994) Christian Moretti; Eric Deharo; Michel Sauvain; Claude Jardel; Pedroza-Escobar David; M. Gasquet
Antiprotozoal activity of Jatrogrossidione from Jatropha grossidentata and Jatrophone from Jatropha isabellii 
(Wiley, 1996) Guillermo Schmeda‐Hirschmann; Iván Razmilic; Michel Sauvain; Christian Moretti; Verónica Francisca Loewe Muñoz; E. Ruiz; Elfride Balanza; Alain Fournet
The activity of jatrogrossidione, the main diterpene of Jatropha grossidentata and jatrophone from Jatropha isabellii was determined against Leishmania and Trypanosoma cruzi strains in vitro as well as against Leishmania amazonensis in vivo. Jatrogrossidione showed a strong in vitro leishmanicidal and trypanocidal activity with IC100 of 0.75 and 1.5–5.0 μg/mL, respectively. Under similar conditions, the IC100 of glucantime, ketoconazole and pentamidine towards Leishmania strains were >100, 50–100 and 1 μg/mL, respectively. The IC50 of jatrogrossidione was <0.25 μg/mL against amastigote forms of Leishmania infecting macrophages, with toxicity at concentrations higher than 0.5 μg/mL. BALB/c mice infected with L. amazonensis strain PH 8 were treated 24 h after infection with jatrogrossidione and jatrophone for 13 consecutive days. Jatrophone at 25 mg/kg/day subcutaneously administered was significantly active (p<0.05) against the virulent strain PH 8 of L. amazonesis; it was more active than Glucantime at 112 mg Sbv per kg/day. Subcutaneous administration of jatrophone, however, proved to be too toxic under our assay conditions. Assays of single local treatment on the footpad infection 2 weeks after inoculation of L. amazonensis indicated that jatrogrossidione and jatrophone were inactive at the selected doses.
Antiprotozoal activity of Jatrogrossidione from Jatropha grossidentata and Jatrophone from Jatropha isabellii
(Wiley, 1996) Guillermo Schmeda‐Hirschmann; Iván Razmilic; Michel Sauvain; Christian Moretti; Verónica Francisca Loewe Muñoz; E. Ruiz; Elfride Balanza; A. Fournet
The activity of jatrogrossidione, the main diterpene of Jatropha grossidentata and jatrophone from Jatropha isabellii was determined against Leishmania and Trypanosoma cruzi strains in vitro as well as against Leishmania amazonensis in vivo. Jatrogrossidione showed a strong in vitro leishmanicidal and trypanocidal activity with IC100 of 0.75 and 1.5–5.0 μg/mL, respectively. Under similar conditions, the IC100 of glucantime, ketoconazole and pentamidine towards Leishmania strains were >100, 50–100 and 1 μg/mL, respectively. The IC50 of jatrogrossidione was <0.25 μg/mL against amastigote forms of Leishmania infecting macrophages, with toxicity at concentrations higher than 0.5 μg/mL. BALB/c mice infected with L. amazonensis strain PH 8 were treated 24 h after infection with jatrogrossidione and jatrophone for 13 consecutive days. Jatrophone at 25 mg/kg/day subcutaneously administered was significantly active (p<0.05) against the virulent strain PH 8 of L. amazonesis; it was more active than Glucantime at 112 mg Sbv per kg/day. Subcutaneous administration of jatrophone, however, proved to be too toxic under our assay conditions. Assays of single local treatment on the footpad infection 2 weeks after inoculation of L. amazonensis indicated that jatrogrossidione and jatrophone were inactive at the selected doses.
Triterpene saponins fromMyrsine pellucida
(Elsevier BV, 1994) Catherine Lavaud; Georges Massiot; Jose ́Bravo Barrera; Christian Moretti; Louisette Le Men‐Olivier