Browsing by Autor "Claude Moulis"

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    Anti-Leishmanial Lindenane Sesquiterpenes from<i>Hedyosmum angustifolium</i>
    (Thieme Medical Publishers (Germany), 2009) Lucia Acebey; Valérie Jullian; Denis Séréno; Séverine Chevalley; Yannick Estevez; Claude Moulis; Stephan Beck; Alexis Valentin; Alberto Giménez; Michel Sauvain
    The aim of this work is the isolation of anti-leishmanial compounds from the ethyl acetate extracts of the bark of HEDYOSMUM ANGUSTIFOLIUM. We have successfully isolated and characterized five sesquiterpenes: one new compound (oxyonoseriolide, 1), one compound isolated for the first time from a natural source (hedyosmone, 2), and three known sesquiterpenes (onoseriolide, 3; chloranthalactone A, 4; and spathulenol, 5) that had not been previously isolated from H. ANGUSTIFOLIUM. The biological activities of 1- 5 showed that onoseriolide ( 3) was the most active compound against axenic amastigotes from LEISHMANIA AMAZONENSIS and L. INFANTUM. Moreover, it was still active on the intramacrophagic amastigotes of L. INFANTUM. The isolated compounds have also been tested on PLASMODIUM FALCIPARUM and against various mammalian cell lines.
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    Bolivianine, a New Sesterpene with an Unusual Skeleton from <i>Hedyosmum angustifolium,</i> and Its Isomer, Isobolivianine
    (American Chemical Society, 2007) Lucia Acebey; Michel Sauvain; Stephan Beck; Claude Moulis; Aberto Gimenez; Valérie Jullian
    Bolivianine, a novel sesterpene with an unprecedented skeleton, has been isolated from the trunk bark of Hedyosmum angustifolium (Chloranthaceae), with isobolivianine, an isomer formed under acidic conditions. The structure and relative stereochemistry were elucidated on the basis of spectroscopic data. A hypothesis for biogenesis was made.