Browsing by Autor "Daniela Albers"

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Diagnostic accuracy of placental alkaline phosphatase concentrations in gingival crevicular fluid at early pregnancy in predicting the risk of preeclampsia: a prospective cohort study
(2020) Alejandra Chaparro; Max Mönckeberg; Ornella Realini; Marcela Hern ndez; Fernanda Param; Daniela Albers; Valeria Ram rez; Juan Pedro Kusanovic; Roberto Romero; Gregory E. Rice
Objective: To evaluate the accuracy of concentrations of gingival crevicular fluid (GCF) placental alkaline phosphatase (PLAP) during early pregnancy in identifying women at risk of subsequently developing preeclampsia (PE). Design: Prospective cohort study. Setting: Hospital Sotero del Río, Santiago, Chile. Population: Pregnant women recruited at 11-14 weeks of gestation. Methods: Maternal obstetric and periodontal histories were obtained. GCF samples were collected for PLAP determination by ELISA assay. Multiple logistic regression models estimated the association between GCF-PLAP concentrations, maternal variables, and PE development. The accuracy performance of the prediction model was established. Results: 460 women were recruited into the study, and 412 completed their pregnancy follow–up visit. 18 (4.3%) women developed PE. GCF-PLAP concentrations and systolic blood pressure measurements were significantly higher in women who developed PE (p=0.015 and p<0.001, respectively). An association between first-trimester systolic blood pressure, GCF-PLAP, and PE were established. The predictive model had a sensitivity of 83%, specificity of 72%, a positive predictive value (PPV) of 12%, and a negative predictive value (NPV) of 99%. The positive and negative likelihood ratios were 2.9 and 0.3, respectively, thus classifying correctly 72% of women who subsequently developed PE. The area under the receiver operating characteristic curve was 0.77 for PE and 0.85 for preterm PE. Conclusions: An algorithm that includes PLAP concentrations in GCF and blood pressure during early pregnancy may aid in the identification of women at risk of developing PE. Funding: FONDEF IDeA: ID16I10452. NICHD/NIH/DHHS: HHSN275201300006C. Keywords: a cohort study, gestation, hypertension, placental biomarkers, risk prediction model.
Evaluation of the Comprehensive Oral Health Program (GES-60) on Oral Health Indicators and Oral Health-Related Quality of Life in Older Adults in Ovalle, Chile
(Universidad de Antioquia, 2026) Javiera Zúñiga-González; Tomás Morales-Costa; Claudia Cristoffanini-Bonino; Daniela Albers
Introduction: this study evaluated the Comprehensive Oral Health Program (GES-60) and its association with oral health indicators and Oral Health-Related Quality of Life (OHRQoL) in older adults in Ovalle, Chile. Methods: a non-concurrent cohort study was conducted comparing users and non-users of the GES-60 program, who were surveyed and clinically examined for periodontal status, oral hygiene habits, smoking, type 2 diabetes mellitus, and OHRQoL assessed using the OHIP-7Sp scale. Results: a total of 238 older adults were examined (102 users and 136 non-users). Access to the program did not differ by sex (Chi-square test; p = 0.935). Awareness of the benefit was low (18.5 %). Users and non-users brushed with fluoride toothpaste twice or more a day (83.6 %). More than 50 % of the sample was diagnosed with periodontitis and perceived to have good OHRQoL. Among participants with type 2 diabetes mellitus, 79.8 % brushed twice or more daily (p < 0.0001) and 75 % used fluoride toothpaste at the same frequency (p < 0.0001). No association was found between OHRQoL and the use of GES-60 (Fisher's exact test; p=0.142). Conclusions: most older adults demonstrated adequate oral hygiene habits and good self-perceptions of OHRQoL. The high prevalence of periodontitis suggests possible gaps in periodontal disease awareness. These findings highlight the need to strengthen educational components to help users better understand the OHIP-7Sp survey.
Periodontitis and placental growth factor in oral fluids are early pregnancy predictors of gestational diabetes mellitus
(Wiley, 2018) Alejandra Chaparro; E. Zuñiga; Manuel Varas‐Godoy; Daniela Albers; Valeria Ramı́rez; Marcela Hernández; Juan Pedro Kusanovic; Stephanie Acuña‐Gallardo; Gregory E. Rice; Sebastián E. Illanes
Within the limitations of the present study, the results support that first trimester maternal glycemia combined with GCF-PlGF concentrations could be a surrogate biomarker for the future development of GDM in pre-symptomatic women.