Browsing by Autor "Edison Osorio"

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    Antiprotozoal and cytotoxic activities in vitro of Colombian Annonaceae
    (Elsevier BV, 2007) Edison Osorio; Gabriel Jaime Murillo Arango; Nora Jiménez; Fernando Álzate; Grace Ruiz; David Gutiérrez; Marco Antonio Paco; Alberto Giménez; Sara M. Robledo
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    Avtividad antiplamódica in vitro e inhibición de la formación de la beta-hematina de plantas colombianas de la familia Annonaceae
    (2005) Edison Osorio; Gabriel Jaime Murillo Arango; Edison Parra; Katalina Muñoz-Durango; Grace Ruiz; David Gutiérrez; Marco Antonio Paco; Alberto Giménez
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    In Vitro and In Vivo Cytotoxicities and Antileishmanial Activities of Thymol and Hemisynthetic Derivatives
    (American Society for Microbiology, 2005) Sara M. Robledo; Edison Osorio; Diana L. Muñoz; Luz Jaramillo; Adriana Restrepo; Gabriel Jaime Murillo Arango; Iván Darío Vélez
    The in vitro and in vivo antileishmanial and cytotoxic activities of thymol and structural derivatives in comparison to those of Glucantime were studied. The results showed here suggest that thymol and hemisynthetic derivatives have promising antileishmanial potential and could be considered as new lead structures in the search for novel antileishmanial drugs.
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    Pharmacological Potential of Peruvian Eustephia Species (Amaryllidaceae): Alkaloid Diversity, Cholinesterase Inhibition, and Anti-Trypanosoma cruzi Activity
    (Multidisciplinary Digital Publishing Institute, 2025) Olimpia Llalla-Córdova; Javier E. Ortiz; Mauricio Piñeiro; Luciana R. Tallini; Laura Torras‐Claveria; Hibert Huaylla; Ana María Mejía‐Jaramillo; Omar Triana‐Chávez; Edison Osorio; Lorena Luna
    The Amaryllidaceae family represents a prolific source of pharmacologically active compounds, boasting over 700 diverse alkaloids identified to date. However, the genus <i>Eustephia</i> (Amaryllidoideae subfamily) remains largely unexplored. This study focused on the alkaloid profiles and pharmacological potential of bulb and leaves extracts from three Peruvian <i>Eustephia</i> species (<i>E. coccinea</i>, <i>E. darwinii</i>, and <i>E. hugoei</i>). The phenolic and flavonoid levels as well as the antioxidant activity of the methanolic extracts, were determined. Twenty-six alkaloids were identified in the alkaloid-enriched extracts (AEEs). Homolycorine-type alkaloids predominated in <i>E. darwinii</i> and <i>E. hugoei</i>, whereas <i>E. coccinea</i> displayed greater chemical diversity showing assoanine as the main detected alkaloid. In addition, candimine was widely distributed across species. AEEs showed stronger enzyme inhibition of acetylcholinesterase (AChE) compared to butyrylcholinesterase (BuChE). Notably, the AEE from <i>E. coccinea</i> leaves showed the highest AChE inhibition (IC<sub>50</sub> = 1.82 μg/mL), while the AEE from bulbs exhibited the strongest BuChE inhibitory activity (IC<sub>50</sub> = 61.22 μg/mL). Regarding anti-<i>T. cruzi</i> effect, the <i>E. darwinii</i> bulbs AEE was most potent and selective against amastigote forms (IC<sub>50</sub> = 2.1 μg/mL; SI = 8.83). These findings underscore the potential of Peruvian <i>Eustephia</i> species as promising sources of pharmacologically relevant alkaloids, with possible applications in neurodegenerative disorders and Chagas disease.