Browsing by Autor "Elfride Balanza Erquicia"

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Concentración de malondialdehido, en sujetos residentes de gran altura: estudio exploratorio
(National Institute of Health of Peru, 2017) Ingrid Gaby Melgarejo Pomar; Elfride Balanza Erquicia; Lizeth Torrez Colmena; Sergio Quisberth Barrera; Pilar Leina Suzaño Vargas
El objetivo fue investigar el comportamiento del malondialdehido (MDA), biomarcador de estrés oxidativo, a grandes altitudes (3500–4200 m de altitud). Se realizó un estudio exploratorio en 91 sujetos de las ciudades de La Paz y El Alto seleccionados a través de una encuesta y examen clínico; la determinación de MDA se realizó con una técnica colorimétrica. Las medidas de tendencia central, dispersión y porcentajes se usaron para la descripción de datos, la prueba de Mann Whitney y Kruscal Wallis para explorar diferencias entre varones y mujeres, grupo etario y altitud. La mediana de concentración de MDA fue de 4,1 μmol/L (RIC 2,4–5,4), la mayor concentración se encontró en mayores de 40 años. El valor de la media encontrada es mayor que los referidos para el nivel del mar y supone la influencia de la hipoxia sobre los valores del MDA, sin embargo, no se encontraron diferencias entre sexo y grupos etarios.
[Concentration of Malondialdehyde in Subjects Living at High Altitudes: Exploratory Study].
(National Institutes of Health, 2018) Ingrid Gaby Melgarejo Pomar; Elfride Balanza Erquicia; Lizeth Torrez Colmena; Sergio Quisberth Barrera; Pilar Leina Suzaño Vargas
The objective of this study was to determine the levels of malondialdehyde (MDA), an oxidative stress biomarker, in individuals living at high altitudes (3500-4200 m). This exploratory study evaluated 91 subjects from La Paz and El Alto using a questionnaire and clinical examination. MDA levels were measured using a colorimetric technique. Measures of central tendency, dispersion, and percentages were used to describe data, and the Mann-Whitney test and Kruskal-Wallis test were used to assess differences between the sexes, age groups, and altitudes. The median concentration of MDA was 4.1 μmol/L (RIC 2.4-5.4) and the highest concentration of MDA was found in individuals older than 40 years. The average MDA levels were higher than those found at sea level, a result we believe is due to the effect of hypoxia. However, there were no differences in the MDA levels between the sexes or age groups.
Síndromes clínicos en la infección aguda y crónica de la COVID-19 en población nativa y residente de altura durante la primera y segunda ola
(University of San Martín de Porres, 2023) Ingrid Gaby Melgarejo Pomar; Elfride Balanza Erquicia; Elfride Balanza Erquicia; Universidad Mayor de San Andrés, Facultad de Medicina, Enfermería, Nutrición y Tecnología Médica, Instituto Boliviano de Biología de Altura (IBBA). Licenciada en Bioquímica, asistente de Investigación i
Objective: To classify into clinical syndromes the symptoms of acute and chronic COVID-19 infection among a high altitude population during the first and second waves. Materials and methods: A prospective and longitudinal study. An online questionnaire was administered to people infected with SARS-CoV-2 during the first and second waves from March 2020 to December 2021. The measures of central tendency were expressed as means and percentages with a 95 % confidence interval. The chi-square test associated the variables and considered a p value ≤ 0.05. IBM SPSS Statistics statistical software V22 was used. Results: A total of 87 women and 63 men with an average age of 44.12 (± 14.56) years participated in the research, out of whom 48.70 % and 51.30 % were infected in the first and second waves, respectively. The 59 reported symptoms were grouped into 19 syndromes for the acute phase and 18 for the chronic phase. The most frequent syndromes in the acute phase were incomplete acute toxic infectious disorders (79.30 %), taste and smell disorders (60.70 %) and anxiety and depressive disorders (56.79 %). Chronic COVID was called post-COVID-19 syndrome and was subdivided into three phases: post-acute, chronic and long-haul. In the post-acute and chronic phases, muscle fatigue and weakness as well as pain and aches appeared, persisting until the long-haul phase, where lingering symptoms were considered sequelae. Post-COVID-19 syndrome occurred in 64.55 % of the participants. Conclusions: This study has shown an increased frequency of symptoms affecting the central and peripheral nervous system in both the acute phase and post-COVID-19 syndrome. It is possible that hypobaric hypoxia, by prolonging inflammation and stimulating oxidative stress, may lead to a longer post-COVID-19 syndrome, with a greater impact on the nervous system.