Browsing by Autor "F. Molleda"

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    Treatment of Bolivian Mucosal Leishmaniasis with Miltefosine
    (Oxford University Press, 2007) Jaime Soto; Julia Toledo; L Valda; Margarita Balderrama; Irene Maeve Rea; Rolando Sergio Llópiz Parra; J Herrera Ardiles; Paula Soto; Ángel Herrera‐Gómez; F. Molleda
    In this unrandomized trial, oral miltefosine was at least as effective as heroic doses of parenteral amphotericin B. The cure rate for miltefosine was approximately equivalent to historical cure rates using parenteral pentavalent antimony for mild and extensive disease in neighboring Peru. Although gastrointestinal side reactions do occur with miltefosine, its toxicity profile is superior to that of antimony and far superior to that of amphotericin B--in part because of the inherent attractiveness of oral versus parenteral agents. Our results suggest that miltefosine should be the treatment of choice for mucosal disease in North and South America.