Browsing by Autor "Fausto Maldonado-Coronel"

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    Altitude-specific neurocritical care: A case study in the management of traumatic brain injury
    (Elsevier BV, 2025) Fausto Maldonado-Coronel; Catty Castillo-Caicedo; Antonio Viruez‐Soto; Roger Huanca-Payehuanca; Amílcar Tinoco-Solórzano; Daniel Molano-Franco; Christian Arias‐Reyes; Jorge Soliz
    This case illustrates a unique challenge in neurocritical care at high altitude, where sea-level ventilation protocols can be detrimental. It adds novel clinical evidence by showing the pathophysiological consequences and therapeutic reversal of hypercapnia-induced cerebral hyperemia in a high-altitude native with traumatic brain injury (TBI). A 25-year-old man, lifelong resident at 3600 m above sea level (m.a.s.l.), presented with moderate-to-severe TBI following a motor vehicle accident. He exhibited cerebral edema and hemorrhagic contusions on CT, with transcranial Doppler indicating cerebral hyperemia. Initial ventilation based on sea-level PaCO₂ norms led to iatrogenic hypercapnia and cerebral hyperemia. Upon adjusting the ventilatory targets to an altitude-appropriate PaCO₂ range (26–28 mmHg), cerebral blood flow normalized, as confirmed by Doppler. The patient rapidly recovered and was discharged neurologically intact. In high-altitude settings, standard ventilation protocols may provoke secondary cerebral complications. This case highlights the critical importance of individualized, altitude-specific neurocritical strategies, with transcranial Doppler serving as a valuable bedside guide to optimize outcomes in altitude-acclimatized TBI patients. • Sealevel TBI ventilation may cause hypercapnia and cerebral hyperemia in altitud-acclimatized patients. • Setting PaCO 2 to 26-28 mmHg restored cerebral perfusion and improved neurological recovery at altitude. • Highlights the need for altitude-specific neurocritical care to improve TBI outcomes in high-altitude settings.