Browsing by Autor "Fred Gustavo Manrique Abril"

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    DataStatistic/COVID19RtAme: Estimation of time-varying reproduction numbers of COVID-19 in American countries
    (European Organization for Nuclear Research, 2020) Mario Pacheco-López; Cristian F. Téllez-Piñerez; Fred Gustavo Manrique Abril
    This study aimed to estimate the basic reproduction number and the time-varying estimate of effective reproductive number of COVID-19 in American countries as they implemented non-pharmacological strategies for the containment of the SARS-CoV-2 virus. Data sources included COVID-19 epidemic data from Johns Hopkins University’ data repository and official websites of countries with a relatively high incidence of COVID-19. The maximum likelihood method was used to estimate the and . The results showed that El Salvador, the Dominican Republic, Panama, and Peru have the lowest , while the USA and Canada have the highest. Other American countries have an around 1.4. Countries could be divided into three groups based on the varied behavior of over time. The first group started with a high , which decreased post-intervention. The second group started with a low , which then increased at the time of intervention until it finished decreasing. In the third group (Bolivia and Guatemala), a behavior bias was found. There is a close relationship between and non-pharmacological interventions decreed by governments of countries for the control of the COVID-19 pandemic. There are also immediate changes in the behavior of the indicator, and therefore the progression of the outbreak, when the interventions were implemented closer to the index case for each country.
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    Meningitis sifilítica aguda
    (Elsevier BV, 2011) Efraín Riveros; Fred Gustavo Manrique Abril; Manuel Bustamante Montalvo
    Se trata de un paciente de 28 años de sexo femenino, que presentó un cuadro clínico rápidamente progresivo de cambios en el comportamiento y deterioro del estado de conciencia. Ingresó con puntaje de Glasgow de 8/15 y requirió intubación traqueal. Tenía respuesta plantar extensora bilateral, pupila izquierda midriática de 5 mm, sin respuesta a la luz, ptosis palpebral del mismo lado y nistagmo con componente rápido hacia la izquierda. El contenido de proteínas del líquido cefalorraquídeo fue de 0,86 g/l con pleocitosis moderada de predominio linfocitario. Tres semanas antes del ingreso, presentó parto vaginal eutócico; no tuvo control prenatal durante el embarazo. En el recién nacido se demostró serología reactiva para sífilis y FTA-ABS positivo. La paciente también fue hallada reactiva para serología de sífilis en el líquido cefalorraquídeo, con diagnóstico de meningitis sifilítica aguda. La prueba ELISA para VIH fue negativa. A 28 year-old woman presented with a rapidly progressive clinical picture of behavioral changes and altered level of consciousness. She was admitted with Glasgow Coma Score 8/15, 5 mm dilated non-reactive left pupil, right ptosis and nystagmus with left lateral gaze. Protein content at cerebrospinal fluid was 0,86 g/L with pleocytosis. Three weeks earlier, the patient underwent vaginal delivery of a pregnancy without prenatal care, and the newborn was found to be reactive to syphilis serology and positive on FTA-ABS test. The patient was found positive as well for syphilis on serologic tests for syphilis, corresponding yhe picture to neurosyphilis.HIV testing was negative in the patient.