Browsing by Autor "Gabriela Arata-Bellabarba"

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Efecto de la combinación fija de Vildagliptina/Metformina o Sitagliptina/Metformina sobre la lipemia postprandial en pacientes con diabetes tipo 2
(2012) María Alejandra Vergel Yaruro; Alba Salas Paredes; Lenys Buela; Lenín Valeri; Gabriela Arata-Bellabarba; Elsy Velázquez-Maldonado
Objective: to assess the effect of fixed combination of vildagiptin/metformin and sitagliptina/ metformin on postprandiallipemia (PP) in patients with type 2 diabetes mellitus (DM2). Methods: fifty-seven patients with DM2 previously treated with metformin and diet and HbA1c between 6,5-8,5% participated in a 8 weeks randomized, double blind study. An oral fat load was performed at baseline and 8 weeks after treatment with fixed combination of vildagliptin/metformin (grupo 1; n=29) or sita gliptin/metformin (group 2; n=28) twice a day. Blood samples were taken at baseline and at 2 hours interval during 8 hours after oral fat load. Results: integrated postprandial triglyceride response (AUC-TG) decreased in 76% of patients of group 1 and 64% of group 2. Fasting lipoprotein profile did not show significant changes post treatment. Both fasting and 2h postprandial glucose and HbA1c showed a significant decrease in both groups, in association with a decrease of body mass index and blood pressure (p<0,001). No adverse effects were observed. Conclusions: besides improving glucose control, fixed combination of vildagliptin/metformina or sita gliptina/metformin treatment has a beneficial effect postprandial lipemia which is important to improve the cardiometabolic risk of type 2 patients.
Frecuencia de Hipotiroidismo Subclínico en Niños Sanos y con Alteraciones Neurológicas en el Estado Mérida, Venezuela.
(2003) Mariela Paoli-Valeri; Denise Mamán-Alvarado; Virginia Jiménez-López; Angela Arias Ferreira; Guillermo Bianchi; Gabriela Arata-Bellabarba
Frequency of subclinical hypothyroidism in children with and without neurological disorders in Mérida, Venezuela.
(2003) Mariela Paoli-Valeri; Denise Mamán-Alvarado; Virginia Jiménez-López; Angela Arias Ferreira; Guillermo Bianchi; Gabriela Arata-Bellabarba
Índice trigliceridos/cHDL en el embarazo: Interrelación con índices de resistencia a la insulina y antropometría fetal
(2013) Ana Victoria Becerra Leal; Alba Salas Paredes; Lenys Buela; Maria Alejandra Sosa; Gabriela Arata-Bellabarba; Lenín Valeri; Elsy Velázquez-Maldonado
Objective: to determine the relationship between triglycerides/high density lipoprotein cholesterol (TG/HDLc) index and indexes HOMAIR (Homeostasis Model assessment) y QUICKI (Quantitative Insulin Sensitivity Check Index) and fetal anthropometrics in healthy pregnant women. Methods: This cross-sectional study evaluated 91 healthy pregnant women aged 16-41 yr, categorized by gestational age: first trimester (TI, n = 29); second trimester (TII, n = 32); third trimester (TIII, n = 30). Oral glucose tolerance test (75g) was performed. Plasma concentrations of glucose, insulin, triglyceride (TG), total cholesterol (TC) and HDLc were measured. Low density lipoprotein cholesterol (LDLc), no-HDLc, TG/HDLc index, HOMA IR and QUICKI were calculated. Fetal abdominal circumference (FAC) and estimated fetal body weight (EFBW) were evaluated by abdominal ultrasound; uterine height (UH), blood pressure and birth weight were registered. Results: Mean plasma TG, total cholesterol, LDLc, no-HDLc and TG/HDLc, HOMA IR and QUICKI indexes were significantly higher in TII and TIII compared to TI. In all women analysis, both TG/HDLc and no-HDLc showed a significant correlation with pregestational body mass index (BMI) (r = 0.30, p<0,01; r = 0,26, p<0,05 respectively), FAC (r= 0,38, p<0,05; r = 0,50,, p<0,01 respectively), EFBW (r = 0,39, p<0,01; r = 0,50, p<0,05 respectively) and UH (r= 0,485, p<0,001).
Interrelación de índices de resistencia y sensibilidad a la insulina con variables antropométricas y metabólicas de mujeres del tercer trimestre de embarazo y recién nacido a término
(2015) Alba Salas Paredes; Secundino A Galicia Colina; María Alejandra Sosa Peña; Gabriela Arata-Bellabarba; Lenys Buela; Elsy Velázquez-Maldonado
objective: To evaluate the relationship between insulin resistance and sensibility indexes with anthropometrics and metabolic parameters in third trimester of pregnant women and normal term newborns.
Relación entre la concentración de leptina, insulina, norepinefrina y presión arterial en embarazadas sanas
(2004) Alba Jeanette Salas Paredes; Elsy Velázquez-Maldonado; Vanesa Villarroel; Gabriela Arata-Bellabarba
Objective. To evaluate the possible relationship between the plasma concentration of leptin, insulin and norepinephrine in healthy pregnant women and, to examine if these variables are related with blood pressure in this population. Methods. Seventy seven healthy women were studied: 61 pregnant (1 st trimester: 19; 2 nd trimester: 24, 3 rd trimester: 18) and 16 non-pregnant healthy women (controls). At baseline and fasting conditions a blood sample was taken for plasma determination of leptin, insulin and glucose. Plasma concentration of norepinephrine (NE), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean blood pressure (MBP) and heart rate (HR) were obtained at baseline supine position and after 10 min of standing position (ortosthatic change). Insulin resistance index (HOMAIR, Model Homeostasis Assessment) and sensitivity sensitivity index (QUICKI, Quantitative Insulin Sensitivity Check Index) were calculated. Results. In pregnant women, BP was normally, however compared with controls, second trimester pregnant women showed lower values of MBP, DBP (p<0,01 y p<0,05 respectively); no significant differences were observed between first and third trimester. HR was mainly and significantly higher at third trimester pregnant women (p<0,0001). No significant differences in glucose and insulin plasma concentration were observed between the studied groups, HOMA-IR was significantly lower at second trimester (p<0,05) and sensitivity index QUICKI was higher at first and second trimester of pregnancy (p<0,05). No significant differences of basal and ortosthatic norepinephrine plasma concentrations were observed between the three trimesters pregnant women and controls. In pregnant women the increased levels of leptin are related to body mass index and SBP but not with insulin levels. The increased value of HR is related to plasma NE concentration. SBP and HR are related to BMI, which in turn, is related to NE concentration. Conclusions. In healthy pregnant women, leptin was related to SBP and BMI but not with, NE, however, the increase in