Browsing by Autor "Gabrielle B. Rocque"

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    472 Utility of [89Zr]Trastuzumab-PET/MRI Imaging for Quantitative Assessment of Tumor Heterogeneity In HER2+ Breast Cancer
    (Cambridge University Press, 2024) Ameer Mansur; Moozhan Nikpanah; Johnathan McConathy; Erica Stringer-Reasor; Gabrielle B. Rocque; Ahmed Elkhanany; Katia Khoury; Nusrat Jahan; Suzanne E. Lapi; Anna G. Sorace
    OBJECTIVES/GOALS: This study was performed to explore the capabilities of simultaneous [89 Zr]trastuzumab-PET/MRI acquisition in a cohort of metastatic HER2+ breast cancer. The insights derived provide additional noninvasive characterization and precise intratumoral analysis tools for healthcare providers. METHODS/STUDY POPULATION: A total of 13 patients, aged between 40 and 70, diagnosed with HER2-positive breast cancer, were selected to participate in this study. Whole-body [89 Zr]trastuzumab-PET/MR imaging was performed 5 ± 1 days post-injection of the radiopharmaceutical during ongoing HER2-directed therapy. Concurrently acquired T1-weighted MRI facilitated the identification of normal organ and tumor regions of interest, which were further analyzed for mean ADC and mean standardized uptake value. Multiparametric intratumoral habitat analysis was performed. Utilizing the median metric values, tumors were evaluated for heterogeneity, specifically assessing high and low HER2 expression through an image processing framework in conjunction with ADC metrics. Long-term treatment response evaluation is ongoing. RESULTS/ANTICIPATED RESULTS: Initial analysis indicate all tumors exhibited higher overall uptake of [89 Zr]trastuzumab across various sites including the bone (p=0.019), brain (p=0.014), and breast (p=0.069), when compared to corresponding normal organs. Additionally, increased ADCmean values were observed in all regions besides brain tumors (bone: p=0.002, brain: p=0.5, breast: p=0.03, juxtapulmonary: p=0.037), indicating distinct patterns of cellularity. Notably, one of five patients with a breast lesion, who exhibited a complete response to HER2-targeted therapy, exhibited the highest breast lesion SUVmean. Brain and lymph node lesions demonstrated intratumoral heterogeneity of HER2 expression. Qualification of multi parametric maps is anticipated to inform on intratumoral heterogeneity DISCUSSION/SIGNIFICANCE: Despite limitation in clinical applications of quantitative approaches due to lack of standardization of processing, initial investigations, in combining molecular imaging of HER2 and quantitative MRI demonstrate potential in characterizing metastatic HER2+ breast cancer for intratumoral classification and therapeutic stratification.
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    Race, Stress, and Breast Cancer: A Scoping Review
    (2024) Noon Eltoum; Faris Alamin; Keyonsis Hildreth; Sara Abdelrahim; Ritu Aneja; K. E. Reeder-Hayes; Abby R. Rosenberg; Kathryn A. Kaiser; Gabrielle B. Rocque
    <title>Abstract</title> <bold>Objective</bold> Toxic stress may influence breast cancer (BC) risk and progression through various physiological and biological pathways, potentially differing based on racial categories. We systematically reviewed the literature on the relationship between race, stress, and BC.<bold>Methods</bold> We searched PubMed (prior to August 2023), Embase, Web of Science, PsycINFO, and Scopus (prior November 2023) to identify relevant peer-reviewed studies. Two independent reviewers screened titles, abstracts, and full text, with disagreements resolved by discussion or a third reviewer. Data extraction and thematic synthesis were conducted independently.<bold>Results</bold> We identified 30 articles, including 21 original observational studies and 9 reviews. Primary studies explored biological markers including measures of allostatic load (AL), epigenetic changes, and social determinants of health. Studies explored biological marker, AL, epigenetic changes, and social determinants of health. Black women with BC exhibited higher AL and shorter telomeres compared to White women. Epigenetic modifications were associated with social determinants, potentially influencing BC risk and aggressiveness. Significant associations were found between neighborhood disadvantage, social support, and psychosocial stress among women of color with BC.<bold>Conclusion</bold> This review provides a landscape view of the current evidence on the complex interplay between social stressors, biological responses, and racial and ethnic disparities in BC outcomes. Findings highlight the significant role of chronic psychosocial stress in the disproportionate burden of breast cancer faced by marginalized groups. Further research is needed to explore mechanisms and evaluate multilevel interventions addressing individual stress management, neighborhood resources, and societal-level policies to improve breast cancer prevention, detection, and management.