Browsing by Autor "Genarino Herrera"

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    High Prevalence of Sexually Transmitted Infections, and High-Risk Sexual Behaviors Among Indigenous Adolescents of the Comarca Ngäbe-Buglé, Panama
    (Lippincott Williams & Wilkins, 2019) Amanda Gabster; Juan Miguel Pascale; Beniamino Cislaghi; Suzanna C. Francis; Helen A. Weiss; Alexander A. Martínez; Alma Ortiz; Mellissa Herrera; Genarino Herrera; César Gantes
    School-going indigenous adolescents in rural Panama have substantial STI burden. Targeted STI screening is required.
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    The Molecular Genetic Epidemiology and Antimicrobial Resistance of Neisseria gonorrhoeae Strains Obtained from Clinical Isolates in Central Panama
    (Multidisciplinary Digital Publishing Institute, 2023) Virginia Núñez-Samudio; Mellissa Herrera; Genarino Herrera; Gumercindo Pimentel-Peralta; Iván Landires
    We aim to analyze <i>Neisseria gonorrhoeae</i> isolates in central Panama, characterize the associated gonococcal antimicrobial resistance (AMR) and conduct molecular epidemiology and genetic typing. We conducted a retrospective study based on <i>N. gonorrhoeae</i> hospital isolates collected between 2013 and 2018. AMR was determined using dilution agar and Etest<sup>®</sup>. Molecular typing was conducted using the Multilocus Sequence Typing (ST) scheme. The isolates analyzed (<i>n</i> = 30) showed resistance to penicillin (38%), tetracycline (40%), and ciprofloxacin (30%), and sensitivity to extended-spectrum cephalosporins and azithromycin. We identified 11 STs, the most frequent of which was ST1901 among the strains with decreased sensitivity and resistance to three types of antibiotics. We identified eight variations for the <i>penA</i> gene, all non-mosaic, with type II LVG as the most frequent (50%). To the best of our knowledge, we conducted the first Central American genomic study that analyzes a collection of gonococcal isolates, which represents a benchmark for future epidemiological and molecular genetic studies. The high prevalence of ciprofloxacin, tetracycline, and penicillin resistance, in addition to the identification of the worldwide spread of multidrug-resistant clone ST1901, should prompt the continuous and reinforced surveillance of AMR, including the molecular epidemiology of <i>N. gonorrhoeae</i> in Panama.