Browsing by Autor "Gonzalo R. Acevedo"

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    Genetic polymorphism of <i>Trypanosoma cruzi</i> bloodstream populations in adult chronic indeterminate Chagas disease patients from the E1224 clinical trial
    (Oxford University Press, 2021) Juan Carlos Ramı́rez; Gonzalo R. Acevedo; Carolina Torres; Rudy Parrado; Anabelle de la Barra; Sandro Villarroel; Lineth García; Joaquím Gascón; Lourdes Ortiz; Faustino Torrico
    Genetic variability of T. cruzi bloodstream populations during post-treatment follow-up did not differ from that observed during chronic infection in the absence of treatment, suggesting that there were no selection events of E1224-resistant parasite populations. This is the first report documenting the genetic polymorphism of natural T. cruzi populations in chronic patients in the context of clinical trials with trypanocidal drugs.