Browsing by Autor "Guillermo Valenzuela-Nieto"

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    Author response: Specific proteolysis mediated by a p97-directed proteolysis-targeting chimera (p97-PROTAC)
    (2025) Constanza Salinas-Rebolledo; Javier Blesa; Guillermo Valenzuela-Nieto; David Schwefel; Natalia López-González del Rey; Maxs Méndez-Ruette; Janine Burkhalter; Elizabeth Carrazana; Francisca Díaz-Tejeda; Ignacio Arias Catalán
    Synthetic adaptors combining camelid nanobodies with the UBX domain of the p97 adaptor FAF1 enable targeted substrate delivery to p97, establishing an E3 ubiquitin ligase-independent mechanism for selective protein degradation.