Browsing by Autor "Hibert Huaylla"

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    Mastigostyla I. M. Johnst. in Bolivia: three new species and new data on M. cardenasii R. C. Foster
    (Springer Science+Business Media, 2010) Hibert Huaylla; Paul Wilkin; Odile Weber
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    Pharmacological Potential of Peruvian Eustephia Species (Amaryllidaceae): Alkaloid Diversity, Cholinesterase Inhibition, and Anti-Trypanosoma cruzi Activity
    (Multidisciplinary Digital Publishing Institute, 2025) Olimpia Llalla-Córdova; Javier E. Ortiz; Mauricio Piñeiro; Luciana R. Tallini; Laura Torras‐Claveria; Hibert Huaylla; Ana María Mejía‐Jaramillo; Omar Triana‐Chávez; Edison Osorio; Lorena Luna
    The Amaryllidaceae family represents a prolific source of pharmacologically active compounds, boasting over 700 diverse alkaloids identified to date. However, the genus <i>Eustephia</i> (Amaryllidoideae subfamily) remains largely unexplored. This study focused on the alkaloid profiles and pharmacological potential of bulb and leaves extracts from three Peruvian <i>Eustephia</i> species (<i>E. coccinea</i>, <i>E. darwinii</i>, and <i>E. hugoei</i>). The phenolic and flavonoid levels as well as the antioxidant activity of the methanolic extracts, were determined. Twenty-six alkaloids were identified in the alkaloid-enriched extracts (AEEs). Homolycorine-type alkaloids predominated in <i>E. darwinii</i> and <i>E. hugoei</i>, whereas <i>E. coccinea</i> displayed greater chemical diversity showing assoanine as the main detected alkaloid. In addition, candimine was widely distributed across species. AEEs showed stronger enzyme inhibition of acetylcholinesterase (AChE) compared to butyrylcholinesterase (BuChE). Notably, the AEE from <i>E. coccinea</i> leaves showed the highest AChE inhibition (IC<sub>50</sub> = 1.82 μg/mL), while the AEE from bulbs exhibited the strongest BuChE inhibitory activity (IC<sub>50</sub> = 61.22 μg/mL). Regarding anti-<i>T. cruzi</i> effect, the <i>E. darwinii</i> bulbs AEE was most potent and selective against amastigote forms (IC<sub>50</sub> = 2.1 μg/mL; SI = 8.83). These findings underscore the potential of Peruvian <i>Eustephia</i> species as promising sources of pharmacologically relevant alkaloids, with possible applications in neurodegenerative disorders and Chagas disease.
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    Pinguicula chuquisacensis (Lentibulariaceae), a new species from the Bolivian Andes, and first insights on phylogenetic relationships among South American Pinguicula
    (Botanic Garden and Botanical Museum Berlin, 2008) Stephan Beck; Andreas Fleischmann; Hibert Huaylla; Kai Müller; Thomas Borsch
    Beck, S. G., Fleischmann, A., Huaylla, H., Müller, K. F. & Borsch, T.: Pinguicula chuquisacensis (Lentibulariaceae), a new species from the Bolivian Andes, and first insights on phylogenetic relationships among South American Pinguicula. — Willdenowia 38: 201–212. — ISSN 0511-9618; © 2008 BGBM Berlin-Dahlem. doi:10.3372/wi.38.38115 (available via http://dx.doi.org/)Pinguicula chuquisacensis is described and illustrated as a new species from the department of Chuquisaca of Bolivia. Data on distribution, ecology and a key for identification among other central Andean species are given. DNA sequence data are presented for this new taxon and related Andean species of Pinguicula for the first time. The plastid tree reveals a lineage of central Andean species (within the clade of tropical growth type species), whereas the northern Andean (Colombia, Venezuela) P. elongata appears distantly related and sister to all remaining taxa of the Mexican-Central American-Caribbean clade of Pinguicula.