Browsing by Autor "Jaime Delgado"

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Propuesta de una ficha de evaluación psicomotora de 0 a 5 años para el seguimiento al neurodesarrollo infantil
(2020) Ivonne Ramírez; Jaime Delgado; Carolina Maldonado; Lucía Pérez
Children in development matters and requires professional supervision with contextualized tools to make the assessment of psychomotor progress infant from its earliest days, which is often underestimated in controlling the growth and development of children in some of our health centers means. The present study concerns the problem of psychomotor evaluation in children from birth to five years of life, although the health system considers controlling the development of the infant, evaluations of psychomotor development are made with several instruments not validated in context where they are employed, but for studies in neighboring countries or synthesis of various instruments without previous scientific studies. The study shows that monitoring of the psychomotor development in our environment is not a priority for the control of child growth, though no doubt the control of immunizations, weight and height, can not be neglected; nor should detract from the timely detection of changes in motor development, sensory and psychomotor tracking capabilities of the infant during the first six years of life. This study culminated in the presentation of an instrument for measuring psychomotor development based on a validation in 1000 children under standard tools systematised criteria employed by the different health centers, public, private and central parts of the Program for Support of Children; supplemented according to current trends on proposing an alternative validated in the population identified, submitted in physical form and electronics.
Sesquiterpene lactones isolated from a medicinal plant of the Venezuelan Andes
(Wiley, 2008) Jaime Delgado; Graciela Dı́az de Delgado; Julia Bruno-Colmenárez; Valentina Cote; Juan M. Amaro‐Luis
Most of nucleoside 5'-monophosphates have been extensively investigated as regards their structure for long, but potassium salts of them have never been studied by the use of X-ray crystallography. The results of structural investigations on five mono-and dipotassium salts of two purine [K2(AMP) . 6H2O, K(IMP) . 3H2O] and two pyrimidine [K2(CMP) . 6.25H2O, K(UMP), K2(UMP) . 5H2O] ribonucleotides will be presented. The K + salts crystallize with Z' = 1-4 for the respective crystal. In all the mono-/dianions, the orientation of the base with respect to the sugar ring is anti, which is typical for nucleotides. The ribose rings in AMP and UMP salts exist in ideal envelope conformations: 2 E in two dianions in K2(AMP) . 6H2O and two dianions in K2(UMP) . 5H2O, and 3 E in the monoanion in K(UMP). The sugar rings in the remaining crystals are slightly deformed from the ideal pucker, with the nearest descriptors being: 3 T2 for the IMP monoanion, 2 T1 for two CMP dianions and 3 T4, 2 E for two remaining CMP dianions. The orientation of the phosphate relative to the ribose ring is the same in all the anions: gauche-gauche, which is characteristic of the 5'-nucleotides. The arrangement of the terminal phosphate atoms relative to the ester C5' is antiperiplanar (ap) for one of O atoms and +/-synclinal (+/-sc) for the others in most of the presented nucleotides. However the phosphate group in the IMP monoanion is disordered and exists in two orientations: typical ap/sc and quite uncommon sp/ac.