Browsing by Autor "Janet Pullockaran"

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    Hypoglycemia and the Origin of Hypoxia-Induced Reduction in Human Fetal Growth
    (Public Library of Science, 2009) Stacy Zamudio; Tatiana Torricos; Ewa Fik; Maria Oyala; Lourdes Echalar; Janet Pullockaran; Emily Tutino; Brittney Martin; Sonia Belliappa; Elfride Balanza
    Our results support that preferential anaerobic consumption of glucose by the placenta at high altitude spares oxygen for fetal use, but limits glucose availability for fetal growth. Thus reduced fetal growth at high altitude is associated with fetal hypoglycemia, hypoinsulinemia and a trend towards lactacidemia. Our data support that placentally-mediated reduction in glucose transport is an initiating factor for reduced fetal growth under conditions of chronic hypoxemia.