Browsing by Autor "Jean-Pierre Dedet"

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A randomized trial of amphotericin B alone or in combination with itraconazole in the treatment of mucocutaneous leishmaniasis
(Instituto Oswaldo Cruz, Ministério da Saúde, 1995) Luis Valda Rodriguez; Jean-Pierre Dedet; Virginia Paredtes; Cristo A Carrasco Mendoza; Fernando Cárdenas
A randomized trial of amphotericin B (AB) alone and in combination with oral itraconazole (IZ) is carried out in two groups of 10 mucocutaneous leishmaniasis patients from Bolivia and Peru. AB+IZ combination is no better than AB monotherapy, as far as efficacy and tolerability are concerned. No antagonism was detected.
Computer-aided identification of insect vectors
(Elsevier BV, 1989) J Lebbe; R. Vignes; Jean-Pierre Dedet
Evidence for a Major Gene Controlling Susceptibility to Tegumentary Leishmaniasis in a Recently Exposed Bolivian Population
(Elsevier BV, 1997) Alexandre Alcaïs; Laurent Abel; C. David; M Torrez; Philippe Flandre; Jean-Pierre Dedet
Fifteen years of cutaneous and mucocutaneous leishmaniasis in Bolivia: a retrospective study
(Oxford University Press, 1993) C. David; L. Dimier-David; Fernando Vargas; M Torrez; Jean-Pierre Dedet
This paper present the results of a retrospective study of cases of cutaneous and mucocutaneous leishmaniasis in Bolivia between 1975 and 1991. The total number of cases reported was 4058, 739 of which were mucous. Three different areas of endemic leishmaniasis are defined in Bolivia.
[Histopathology of mucocutaneous leishmaniasis caused by Leishmania (Vianna) braziliensis].
(National Institutes of Health, 1994) L. Dimier-David; P Ravisse; R Bustillos; F Rollano; F. Mallea; C. David; Philippe Lyèvre; L Valda; Jean-Pierre Dedet
A histopathological study of mucocutaneous leishmaniasis due to Leishmania (Viannia) braziliensis was carried out on 28 cutaneous and 114 mucosal biopsies, taken from Bolivian and Peruvian patients. This study showed similar histopathological findings in cutaneous and mucosal lesions. The cutaneous biopsies showed a strong epidermal hyperplasia occasionnally budding in the dermis. In the ulcerative area, the epidermis was totally necrosed and replaced by a fibrino-leucocytic edge. In the dermis, histio-lympho-plasmocytic infiltration was constantly found. The histiocytes often gathered in follicles sometimes with diffuse fibrosis. The parasites were encountered in 28.6 p. 100 of the biopsies. Whatever the mucosa concerned (i.e. nasal, palatal or lingual), the mucosal lesion was not different from the cutaneous lesion. The malpighian epithelium is either absent or the seat of a pseudo-epitheliomatous hyperplasia. Major histio-lympho-plasmocytic infiltration was found and extended through the depth of the lamina propria. Suppurative and fibrinoid necroses coexisted superficially and sometimes penetrated in depth. The parasites were found in about 30 p. 100 of the cases.
Isoenzyme characterization of 112 Leishmania isolates from French Guiana
(Oxford University Press, 1989) P. Desjeux; Jean-Pierre Dedet
112 Leishmania isolates, obtained in French Guiana from human lesions, phlebotomine sandflies and wild mammals, were characterized by isoenzyme electrophoresis. Leishmania braziliensis guyanensis and L. mexicana amazonensis were found parasitizing different natural hosts. L.b. guyanensis was the dominant species (103 isolates) responsible for most of the human lesions (96.7%). Based on variations observed in 2 enzymes, 3 distinct zymodemes were distinguished within the L.b. guyanensis taxon.
Isoenzyme characterization of Leishmania braziliensis braziliensis isolates obtained from Bolivian and Peruvian patients
(Oxford University Press, 1992) Susana Revollo; L. Dimier-David; C. David; Philippe Lyèvre; Clara Camacho; Jean-Pierre Dedet
Thirty-four Leishmania isolates obtained from Bolivian and Peruvian patients infected with mucocutaneous leishmaniasis were characterized by isoenzyme electrophoresis using 10 enzymatic markers; all belonged to the subspecies L.b. braziliensis. Three isolates showed marked variation compared with the reference strain with respect to 5 or 6 enzymes. These variant isolates originated from patients with forms of the disease which were unresponsive to treatment.
Isolation of Flavans from the Amazonian Shrub Faramea guianensis
(American Chemical Society, 1994) Michel Sauvain; Jean-Pierre Dedet; Nicole Kunesch; J Poisson
In the pursuit of new leishmanicidal natural products, 5,7,4'-trihydroxyflavan [1] and the new product, 5,7-dihydroxy-4'-methoxyflavan [2], were isolated from the Guianian medicinal plant Faramea guianensis.
Isolation of leishmanicidal triterpenes and lignans from the Amazonian lianaDoliocarpus dentatus (dilleniaceae)
(Wiley, 1996) Michel Sauvain; Nicole Kunesch; J Poisson; Jean-Charles Gantier; Philippe Gayral; Jean-Pierre Dedet
The in vitro antileishmanial activity of triterpenes and lignans of an Amazonian medicinal plant, Doliocarpus dentatus (Aublet) Standley, is reported for the first time against amastigotes of Leishmania amazonensis. Terpenes, for example, betulinic acid, betulin and betulinaldehyde were isolated by bioassay-linked extraction. The lignans were characterized as (+) pinoresinol, (+) medioresinol and (−) lirioresinol B.
Lutzomyianuneztovarianglesi (Diptera: Psychodidae) as a probable vector of Leishmaniabraziliensis in the Yungas, Bolivia
(Elsevier BV, 1998) M Torrez; Martha López; François Le Pont; E. Martínez; M Muñoz; David Abril Hervàs; Nina Yaksic; Jorge Arévalo; David Sossa; Jean-Pierre Dedet
Parasitological diagnosis of mucocutaneous leishmaniasis due to Leishmania b. braziliensis in Bolivia
(Brazilian Society of Tropical Medicine, 1991) L. Dimier-David; Christophe David; P Ravisse; R Bustillos; Susana Revollo; Philippe Lyèvre; M Muñoz; Fernando Regla Vargas; Jean-Pierre Dedet
Parasitological diagnosis, using stained smears, culture and pathological examination of biopsy, was studied in 146 patients infected with mucocutaneous leishmaniasis, in Bolivia and Peru. The most efficient parasite detecting technique appeared to be the smear examination in cutaneous lesions (33% positive) and the pathology in case of mucous lesions (28% positive). In both, cutaneous and mucous lesions, the parasites were found most frequently in old lesions.
Prevalence of Trypanosoma cruzi infection in blood banks of seven departments of Bolivia
(Instituto Oswaldo Cruz, Ministério da Saúde, 1990) Roxana Carrasco; Hortensia Miguez; Clara Camacho; Lourdes Echalar; Suzana Revollo; Tania Ampuero; Jean-Pierre Dedet
Trypanosoma cruzi infection was studied in 1,298 sera samples of blood banks from 7 capital departments of Bolivia, using the immunofluorescence test (IFI) and Enzyme Linked Immunosorbent Assay (ELISA). The percentages of positivity in these 7 departments have an average of 28% and are distributed as follows: Sta. Cruz 51%, Tarija 45%, Cochabamba 28%, Sucre 39%, La Paz 4.9%, Oruro 6% and Potosi 24%. The prevalence is related with the altitude levels of the different departments. However in Potosi (3,945 m) we found a 24% of prevalence, probably due to the proximity of endemic valleys to the city. The authors suggest a strict control in blood donors since there exists a great risk of infection.
Rural campaign to diagnose and treat mucocutaneous leishmaniasis in Bolivia.
(National Institutes of Health, 1995) Jean-Pierre Dedet; R Melogno; Fernando Cárdenas; L Valda; C. David; Victoria Gallardo; M Torrez; L. Dimier-David; Philippe Lyèvre; M E Villareal
Mucocutaneous leishmaniasis (MCL) is endemic in the tropical Amazonian lowlands of Bolivia, an area that regularly receives influxes of migratory populations. In these new agricultural development areas, a campaign to diagnose and treat the disease was carried out between 1989 and 1992, in order to provide direct access to MCL treatment in the endemic areas at a standard equivalent to that offered in the urban centres in Bolivia. The campaign led to the creation of decentralized local centres for diagnosis and treatment of the disease. A campaign to inform the population about leishmaniasis was also undertaken and courses were run to educate medical and paramedical personnel. As a result of the campaign, 3285 cases of leishmaniasis were diagnosed, including 2152 cutaneous and 326 mucosal forms. Also, a total of 1888 cases were treated, 1677 of which cutaneous and 211, mucosal.
The 70-kDa heat-shock protein is a major antigenic determinant in human Trypanosoma cruzi/Leishmania braziliensis braziliensis mixed infection
(Elsevier BV, 1992) P.Levy Yeyati; Serge Bonnefoy; Gerardo A. Mirkin; Alain Debrabant; S. Lafon; Alfredo Panebra; E. Gonzalez-Cappa; Jean-Pierre Dedet; M. Hontebeyrie-Joskowicz; Mariano J. Levin