Browsing by Autor "Jennifer L. Hageman"

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Lowland origin women raised at high altitude are not protected against lower uteroplacental O<sub>2</sub> delivery during pregnancy or reduced birth weight
(Wiley, 2011) Colleen G. Julian; Jennifer L. Hageman; Megan J. Wilson; Enrique Vargas; Lorna G. Moore
Lifelong compared with newcomer high-altitude residents have lower uteroplacental O(2) delivery and similar infant birth weights, suggesting that developmental factors are likely not responsible for the protective effect of highland ancestry.
PlGF is greater and sFLT‐1 lower in multigenerational vs. shorter‐term pregnant residents of high altitude
(Wiley, 2008) R. Daniela Dávila; Colleen G. Julian; Vaughn A. Browne; Megan J. Wilson; Jennifer L. Hageman; Henry Yamashiro; Armando Rodríguez; Carmelo Rodriguez; Enrique Vargas; Lorna G. Moore
INTRODUCTION. An imbalance between angiogenic and anti‐angiogenic factors likely plays an etiological role in fetal growth restriction. Since multigenerational high‐altitude (HA) Andean (AND) vs. shorter‐term, European (EUR) ancestry protects against fetal growth restriction at HA, we hypothesized that the angiogenic factor PlGF was elevated and the anti‐angiogenic factor sFlt‐1 reduced. MATERIALS AND METHODS. Pregnant women residing at low (400 m; AND n=36, EUR n=39) or high (3600m; AND n=46, EUR n=33) altitude in Bolivia were studied at 20 and 36 wk of pregnancy and 4 mo postpartum. Plasma sFlt1 and PlGF levels were determined by ELISA and data analyzed by ANOVA. RESULTS. Pregnancy increased PlGF and sFlt‐1 in EUR and AND women (p<0.001). PlGF increased in AND women at HA in early pregnancy and declined at 36 wk compared EUR values (interaction between pregnancy, altitude and ancestry, p<0.05). At HA, sFlt‐1 was greater in EUR than AND women at 20 and 36 wk (p<0.001). The sFlt‐1/PlGF ratio rose from 20 wk to 36 wk in EUR women at both altitudes and in HA AND women but not in the LA AND, and tended to be lower in AND vs. EUR women near term (p<0.10). CONCLUSIONS. Lower sFLT‐1 and higher PlGF levels may help protect multigenerational AND compared with shorter‐term EUR HA‐residents from fetal growth restriction. (NIH HL079647 and HL 14985)
The role of antioxidant & oxidative status in the protection against altitude‐associated reductions in uterine artery (UA) blood flow & fetal growth afforded by Andean ancestry
(Wiley, 2008) Colleen G. Julian; Enrique Vargas; Joe M. McCord; Jennifer L. Hageman; R. Daniela Dávila; Henry Yamashiro; Megan J. Wilson; Carmelo Rodriguez; Armando Rodríguez; Vaughn A. Browne
Objective: To determine the role of antioxidant & oxidative status in the protection of uterine artery blood flow (UAVF) & fetal growth at high altitude in Andean populations. Methods: Erythrocyte catalase (CAT) & superoxide dismutase (SOD), plasma isoprostanes (8‐ISO‐PGF‐2α) & UA VF were measured at 20 & 36w of pregnancy & and in the non‐pregnant state in Andean (AND) & European (EUR) women at low (LA, 416m) or high (HA, 3600m) altitude. CAT, SOD & 8‐iso‐PGF‐2α were assessed by spectrometry, UA VF by Doppler ultrasound & birth weight (BW) by medical records review. Data was analyzed by t‐tests, 1‐ & 2‐way ANOVA. Results: At LA, ancestry had no effect on CAT or SOD. AND had higher CAT (20 & 36w p<0.05) & SOD activity (36w p<0.05) than EUR at HA. At HA, UA diameter and UA VF were greater in AND than EUR. Altitude decreased BW in AND (p<0.05) and EUR (p<0.01), and at HA EUR ancestry reduced BW (β= − 0.238 p<0.05). Small‐for‐gestational age (SGA) infants occurred 2‐times more frequently at HA than LA in EUR. SOD was lower at 20w in SGA at both altitues, or HA alone (all p<0.05). In EUR, CAT tended to be lower at 20w in SGA. 8‐ISO‐PGF2α reduced UA diam (p<0.05) & UA VF (p<0.01) in all women. Conclusion: Elevated endogenous antioxidant activity may contribute to the protection against altitude‐associated reductions in UA blood flow & fetal growth afforded by Andean ancestry. NIH HL079647 ,AHA 0610129Z & NSF BCS‐064719.