Browsing by Autor "Jheremy Sebastian Reyes Barreto"

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piRNAs and PIWI -like proteins in Multiple Myeloma and their future as biomarkers and therapy targets
(2024) Jheremy Sebastian Reyes Barreto; Leidy Viviana Girón Jurado; Maria Paula Montoya Estrada; I. Moreno; Laura Tatiana Picón Moncada; Karen Luna Orozco; Jhonathan David Guevara Ramirez; L Fernandez
Multiple Myeloma (MM) is the second most common hematological malignancy and one of the 19 most frequent types of cancer. Its diagnosis is a challenge due to the low rate of disease recognition, and diagnosis delays lead to the characteristic end-organ damage of the disease. New approaches to tackle that diagnosis challenge are required. Emerging evidence shows that Piwi-interacting RNAs (piRNA) promote increased methylation in MM cells. In this analysis, we delve into the latest discoveries surrounding piRNA biogenesis and functions, offering fresh perspectives on the possible uses of piRNAs in detection and diagnosis in MM. piRNA-823 increases in MM cells and positively correlates with the disease stage. Its tumorigenic actions in MM relate to intercellular communication between MM and vein endothelial cells. These findings provide the necessary information to highlight the possible role of piRNA-823 as a biomarker for MM diagnosis.
piRNAs and PIWI-like proteins in cancer and their future as biomarkers and therapeutic targets in lung cancer: a systematic review
(2025) Jheremy Sebastian Reyes Barreto; Maria Alejandra Rodríguez Brilla; Larissa Rodrigues Garcia; Ana Margarita Baldión
Introduction: This systematic review evaluates the current evidence on the role of PIWI-interacting RNAs (piRNAs) in lung cancer, emphasizing their diagnostic and therapeutic potential. Lung adenocarcinoma, a major global health concern, necessitates exploration of alternatives to traditional methods. piRNAs, small non-coding RNAs, are abnormally expressed in cancerous tissues and biological fluids, indicating their potential as biomarkers and therapeutic targets. Methods: A comprehensive search was performed in PubMed and ScienceDirect databases according to PRISMA guidelines. The search focused on studies examining piRNA expression, their diagnostic value in LUAD tissues and extracellular vesicles, and their therapeutic implications. Studies published from 2020 onward were included and evaluated for bias and quality. Results: Out of nineteen initially identified papers, five studies met the inclusion criteria. These studies identified specific piRNAs with elevated expression in LUAD, such as piR-hsa-26925 and piR-hsa-5444, which showed strong diagnostic performance (AUC = 0.833). Additionally, piRNAs from extracellular vesicles, including piR-hsa-164586, demonstrated potential for early detection of Non-Small Cell Lung Cancer (AUC = 0.624). Conclusions: piRNAs show promise as non-invasive biomarkers for early diagnosis and potential therapeutic targets in lung cancer. Further research is needed to validate these findings and understand the underlying mechanisms to improve clinical applications.
piRNAs and PIWI-like proteins in cancer and their future as biomarkers and therapy targets in breast cancer
(2024) Jheremy Sebastian Reyes Barreto; Cristian Sebastián Cabezas Varela; Leidy Viviana Girón Jurado; Ana Margarita Baldión
Globally, breast cancer (BC) is the most common type of cancer, with 2.296.840 new cases in 2020 with almost 700.000 related deaths. Due to the high burden this represents, it is imperative to expand horizons to be able to find novel biomarkers and therapeutic targets that can be used to improve prognosis, treatment, and survival of breast cancer patients. In recent years, numerous studies have been conducted looking for the association between piRNAs (PIWI – interacting RNAs) and the development, pathogenesis, metastasis, and progression of different types of cancer, including BC. PiRNAs are small molecules (24-31 nucleotides) that interact with the PIWI-protein complex (PIWI-like proteins - HIWI/HILI in humans) performing regulatory functions by inducing transcriptional, post-transcriptional, translational, and post-translational epigenetic changes, which has been observed to contribute to cancer development through modifications in cell proliferation, transposon silencing, genome rearrangement, epigenetic regulation, protein regulation, and stem cell maintenance. In breast cancer, a strong association has been found between the expression of some piRNAs, PIWI-like proteins and tumor development. If a specific piRNA could be associated with a distinct type of cancer, it could then be used as an early biomarker which would allow for a better prognosis. Findings surrounding these molecular mechanisms could also spark interest in studies focusing on the modification of the expression of piRNAs in cancer cells. In this article, we intend to review in a straightforward manner the current information about piRNAs/PIWI-like proteins focusing on their expression in BC.
piRNAs and PIWI-like proteins in cancer and their future as biomarkers and therapy targets in pancreatic cancer: a systematic review
(2025) Jheremy Sebastian Reyes Barreto; Laura Tatiana Picón Moncada; I. Moreno; L Fernandez
Introduction: This systematic review explores the roles of PIWI-interacting RNAs (piRNAs) and PIWI-like proteins in pancreatic cancer, assessing their potential as diagnostic and therapeutic biomarkers. Recent studies suggest that piRNAs and PIWI proteins play roles in gene regulation associated with cancer progression, positioning them as promising targets in oncology. Methods: The review adhered to PRISMA guidelines, focusing on the potential of piRNAs and PIWI-like proteins as biomarkers for diagnosis, prognosis, or therapeutic prediction in pancreatic cancer. Studies in PubMed, EMBASE, and ScienceDirect were included, focusing on expression data, diagnosis, prognosis, or treatment of pancreatic tumors. Only studies published in English or Spanish from the last five years were considered. Risk of bias was assessed using SYRCLE’s tool, a modified CONSORT checklist, and AMSTAR2. Results: Five key studies were selected. Findings indicate that piR-162725 enhances diagnostic accuracy for early-stage pancreatic cancer in combination with CA19-9, while piR-017061 inhibits pancreatic cancer cell growth through EFNA5 mRNA degradation. PIWIL1 promotes metastasis via a piRNA-independent pathway, and piR-hsa-30937 in small extracellular vesicles creates an immunosuppressive environment in pancreatic neuroendocrine tumors. Conclusions: piRNAs and PIWI-like proteins demonstrate potential as biomarkers and therapeutic targets in pancreatic cancer. Future studies are required to validate these findings in larger cohorts and explore piRNA-based therapies. An in-depth understanding of piRNAs' mechanistic roles could improve early detection and therapeutic outcomes in pancreatic cancer.