Browsing by Autor "Juan Copajira Adrian"

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Prevalence of dementia and mild cognitive impairment in indigenous Bolivian forager‐horticulturalists
(Wiley, 2022) Margaret Gatz; Wendy J. Mack; Helena C. Chui; Emma Law; Giuseppe Barisano; M. Linda Sutherland; James D. Sutherland; Daniel Eid Rodriguez; Raúl Quispe Gutierrez; Juan Copajira Adrian
The prevalence of dementia in this cohort is among the lowest in the world. Widespread intracranial medial arterial calcifications suggest a previously unrecognized, non-Alzheimer's disease (AD) dementia phenotype.
Rapidly declining body temperature in a tropical human population
(American Association for the Advancement of Science, 2020) Michael Gurven; Thomas S. Kraft; Sarah Alami; Juan Copajira Adrian; Edhitt Cortez Linares; Daniel K. Cummings; Daniel Eid Rodríguez; Paul L. Hooper; Adrian V. Jaeggi; Raúl Quispe Gutierrez
Normal human body temperature (BT) has long been considered to be 37.0°C. Yet, BTs have declined over the past two centuries in the United States, coinciding with reductions in infection and increasing life expectancy. The generality of and reasons behind this phenomenon have not yet been well studied. Here, we show that Bolivian forager-farmers (<i>n</i> = 17,958 observations of 5481 adults age 15+ years) inhabiting a pathogen-rich environment exhibited higher BT when first examined in the early 21st century (~37.0°C). BT subsequently declined by ~0.05°C/year over 16 years of socioeconomic and epidemiological change to ~36.5°C by 2018. As predicted, infections and other lifestyle factors explain variation in BT, but these factors do not account for the temporal declines. Changes in physical activity, body composition, antibiotic usage, and thermal environment are potential causes of the temporal decline.
Very Low Prevalence and Incidence of Atrial Fibrillation among Bolivian Forager-Farmers
(Elsevier BV, 2021) Christopher J. Rowan; Michael Eskander; Edmond Seabright; Daniel Eid Rodríguez; Edhitt Cortez Linares; Raúl Quispe Gutierrez; Juan Copajira Adrian; Daniel K. Cummings; Bret Beheim; Kirsten Tolstrup
Tsimane and Moseten show the lowest levels of atrial fibrillation ever reported, 1/20 to ~1/6 of rates in high-income countries. These findings provide additional evidence that a subsistence lifestyle with high levels of physical activity, and a diet low in processed carbohydrates and fat is cardioprotective, despite frequent infection-induced inflammation. Findings suggest that atrial fibrillation is a modifiable lifestyle disease rather than an inevitable feature of cardiovascular aging.
Voluntary collective isolation as a best response to COVID-19 for indigenous populations? A case study and protocol from the Bolivian Amazon
(Elsevier BV, 2020) Hillard Kaplan; Benjamin C. Trumble; Jonathan Stieglitz; Roberta Mendez Mamany; Maguin Gutierrez Cayuba; Leonardina Maito Moye; Sarah Alami; Thomas S. Kraft; Raúl Quispe Gutierrez; Juan Copajira Adrian