Browsing by Autor "Juan Pablo Escalera-Antezana"

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Ageusia and anosmia, a common sign of COVID-19? A case series from four countries
(Springer Science+Business Media, 2020) Jair Vargas-Gandica; Daniel Winter; Rainer Schnippe; Andrea G. Rodriguez‐Morales; Johana Mondragon; Juan Pablo Escalera-Antezana; María del Pilar Trelles-Thorne; D. Katterine Bonilla‐Aldana; Alfonso J. Rodríguez‐Morales; Alberto Paniz‐Mondolfi
Chapare virus hemorrhagic fever (CHHF) in Bolivia, 2020–2025
(Elsevier BV, 2025) Juan Pablo Escalera-Antezana; Rodrigo Daniel Montesinos-Jove; Carlos Eduardo Gonzales-Flores; Claudia Nathaly Arauco-Gutierrez; Jorge Luis Aviles-Sarmiento; Claudia Marcela Montenegro-Narváez; Nestor Freddy Armijo-Subieta; Alfonso J. Rodríguez‐Morales
Chikungunya in Bolivia: Domestic imported case series in Cochabamba
(Elsevier BV, 2018) Juan Pablo Escalera-Antezana; David R. Murillo-García; Christian Gómez; Roberto Carlos Unzueta-Quiroga; Alfonso J. Rodríguez‐Morales
Chikungunya in Bolivia: Still a Neglected Disease?
(Elsevier BV, 2018) Juan Pablo Escalera-Antezana; David R. Murillo-García; Alfonso J. Rodríguez‐Morales
Clinical features of fatal cases of Chapare virus hemorrhagic fever originating from rural La Paz, Bolivia, 2019: A cluster analysis
(Elsevier BV, 2020) Juan Pablo Escalera-Antezana; Omar J. Rodriguez-Villena; Ariel Weimar Arancibia-Alba; Lucia Elena Alvarado-Arnez; D. Katterine Bonilla‐Aldana; Alfonso J. Rodríguez‐Morales
Clinical features of the first cases and a cluster of Coronavirus Disease 2019 (COVID-19) in Bolivia imported from Italy and Spain
(Elsevier BV, 2020) Juan Pablo Escalera-Antezana; Nicolas Freddy Lizon-Ferrufino; Americo Maldonado-Alanoca; Gricel Alarcón-De-la-Vega; Lucia Elena Alvarado-Arnez; María Alejandra Balderrama-Saavedra; D. Katterine Bonilla‐Aldana; Alfonso J. Rodríguez‐Morales
Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis
(Elsevier BV, 2020) Alfonso J. Rodríguez‐Morales; Jaime A. Cardona‐Ospina; Estefanía Gutiérrez‐Ocampo; Rhuvi Villamizar‐Peña; Yeimer Holguin-Rivera; Juan Pablo Escalera-Antezana; Lucia Elena Alvarado-Arnez; D. Katterine Bonilla‐Aldana; Carlos Franco‐Paredes; Andrés F. Henao‐Martínez
Clinical, Laboratory and Imaging Features of COVID-19: A Systematic Review and Meta-analysis
(2020) Alfonso J. Rodríguez‐Morales; Jaime A. Cardona‐Ospina; Estefanía Gutiérrez‐Ocampo; Rhuvi Villamizar‐Peña; Yeimer Holguin-Rivera; Juan Pablo Escalera-Antezana; Lucia Elena Alvarado-Arnez; D. Katterine Bonilla‐Aldana; Carlos Franco‐Paredes; Andrés F. Henao‐Martínez
Introduction: An epidemic of Coronavirus Disease 2019 (COVID-19) begun in December 2019 in China, causing a Public Health Emergency of International Concern. Among raised questions, clinical, laboratory, and imaging features have been partially characterized in some observational studies. No systematic reviews have been published on this matter. Methods: We performed a systematic literature review with meta-analysis, using three databases to assess clinical, laboratory, imaging features, and outcomes of COVID-19 confirmed cases. Observational studies, and also case reports, were included and analyzed separately. We performed a random-effects model meta-analysis to calculate the pooled prevalence and 95% confidence interval (95%CI). Results: 660 articles were retrieved (1/1/2020-2/23/2020). After screening by abstract/title, 27 articles were selected for full-text assessment. Of them, 19 were finally included for qualitative and quantitative analyses. Additionally, 39 case report articles were included and analyzed separately. For 656 patients, fever (88.7%, 95%CI 84.5-92.9%), cough (57.6%, 40.8-74.4%) and dyspnea (45.6%, 10.9-80.4%) were the most prevalent manifestations. Among the patients, 20.3% (95%CI 10.0-30.6%) required intensive care unit (ICU), with 32.8% presenting acute respiratory distress syndrome (ARDS) (95%CI 13.7-51.8), 6.2% (95%CI 3.1-9.3) with shock and 13.9% (95%CI 6.2-21.5%) of hospitalized patients with fatal outcomes (case fatality rate, CFR).Conclusion: COVID-19 brings a huge burden to healthcare facilities, especially in patients with comorbidities. ICU was required for approximately 20% of polymorbid, COVID-19 infected patients and this group was associated with a CFR of over 13%. As this virus spreads globally, countries need to urgently prepare human resources, infrastructure, and facilities to treat severe COVID-19.
Clinical, Laboratory and Imaging Features of COVID-19: A Systematic Review and Meta-analysis
(2020) Alfonso J. Rodríguez‐Morales; Jaime A. Cardona‐Ospina; Estefanía Gutiérrez‐Ocampo; Rhuvi Villamizar‐Peña; Yeimer Holguin-Rivera; Juan Pablo Escalera-Antezana; Lucia Elena Alvarado-Arnez; D. Katterine Bonilla‐Aldana; Carlos Franco‐Paredes; Andrés F. Henao‐Martínez
Introduction: An epidemic of Coronavirus Disease 2019 (COVID-19) begun in December 2019 in China, causing primary concern. Among raised questions, clinical, laboratory, and imaging features have been partially characterized in some observational studies. No systematic reviews have been published on this matter. Methods: We performed a systematic review of the literature with meta-analysis, using three databases to assess clinical, laboratory, imaging features, and outcomes of confirmed cases of COVID-19. All the observational studies, and also case reports, were included. The case reports were analyzed separately. We performed a random-effects model meta-analysis to calculate the pooled prevalence and 95%CI. Measures of heterogeneity, including Cochran&rsquo;s Q statistic, the I2 index, and the &tau;2 test, were estimated and reported.Results: 660 articles were retrieved. After screening by abstract and title, 27 articles were selected for full-text assessment. Of them, 19 were finally included for qualitative and quantitative analyses. Additionally, 39 case report articles were included and analyzed separately. For &gt;656 patients, fever (88.7%, 95%CI 84.5-92.9%), cough (57.6%, 40.8-74.4%) and dyspnea (45.6%, 10.9-80.4%) were the most prevalent clinical manifestations. Among the patients, 20.3% (95%CI 10.0-30.6%) required ICU, with 32.8% presenting ARDS (95%CI 13.7-51.8), 6.2% (95%CI 3.1-9.3) with shock and 13.9% (95%CI 6.2-21.5%) with a fatal outcome.Discussion: COVID-19 is a new clinical infectious disease, causing considerable compromise, especially in patients with comorbidities, requiring ICU in at least a fifth of them and sometimes with fatal outcomes. Additional research is needed to elucidate factors that may mediate the pathogenesis of the severe and fatal associated disease.
Clinical, Laboratory and Imaging Features of COVID-19: A Systematic Review and Meta-analysis
(2020) Alfonso J. Rodríguez‐Morales; Jaime A. Cardona‐Ospina; Estefanía Gutiérrez‐Ocampo; Rhuvi Villamizar‐Peña; Yeimer Holguin-Rivera; Juan Pablo Escalera-Antezana; Lucia Elena Alvarado-Arnez; D. Katterine Bonilla‐Aldana; Carlos Franco‐Paredes; Andrés F. Henao‐Martínez
Introduction: An epidemic of Coronavirus Disease 2019 (COVID-19) begun in December 2019 in China, causing a Public Health Emergency of International Concern. Among raised questions, clinical, laboratory, and imaging features have been partially characterized in some observational studies. No systematic reviews have been published on this matter. Methods: We performed a systematic literature review with meta-analysis, using three databases to assess clinical, laboratory, imaging features, and outcomes of confirmed cases of COVID-19. All the observational studies, and also case reports, were included and analyzed separately. We performed a random-effects model meta-analysis to calculate the pooled prevalence and 95% confidence interval (95%CI). Measures of heterogeneity were estimated and reported. Results: 660 articles were retrieved. After screening by abstract and title, 27 articles were selected for full-text assessment. Of them, 19 were finally included for qualitative and quantitative analyses. Additionally, 39 case report articles were included and analyzed separately. For 656 patients, fever (88.7%, 95%CI 84.5-92.9%), cough (57.6%, 40.8-74.4%) and dyspnea (45.6%, 10.9-80.4%) were the most prevalent clinical manifestations. Among the patients, 20.3% (95%CI 10.0-30.6%) required intensive care unit (ICU), with 32.8% presenting acute respiratory distress syndrome (ARDS) (95%CI 13.7-51.8), 6.2% (95%CI 3.1-9.3) with shock and 13.9% (95%CI 6.2-21.5%) with a fatal outcome. Discussion: COVID-19 is a new clinical infectious disease, causing considerable compromise, especially in patients with comorbidities, requiring ICU in at least a fifth of them and sometimes with fatal outcomes. Additional research is needed to elucidate factors that may mediate the pathogenesis of the severe and fatal associated disease.
Detección molecular de patógenos de infecciones de transmisión sexual en mujeres y posibles factores asociados
(2025) Víctor Moya Pucho; Jans Velarde Negrete; Ruby Andrea Ingala Orosco; Juan Pablo Escalera-Antezana; Fuantina Teresa Ugarte Vásquez
Objetivo: Detectar patógenos responsables de infecciones de transmisión sexual en mujeres que acuden al Centro de Investigación, Educación y Servicios, mediante PCR multiplex en tiempo real e identificar los posibles factores de riesgo asociados. Métodos: Se realizó un estudio observacional, descriptivo, transversal con enfoque cuantitativo, en 100 mujeres con cuadro clínico de ITS. Los patógenos responsables de ITS se detectaron por PCR multiplex en tiempo real en muestras de hisopado genital. Los posibles factores de riesgo se recolectaron mediante entrevista individual en un cuestionario anónimo. Resultados: En el 48% de las muestras analizadas se detectó al menos un patógeno responsable de ITS, T. pallidum (25%), VHS-2 (24%), VHS-1 (23%), CMV (14%) y C. trachomatis (2%). Los factores de riesgo fueron el desconocimiento sobre ITS con 37%, el inicio de la actividad sexual antes de los 17 años con 31%, el número de parejas sexuales con 52% y las relaciones sexuales sin preservativo con 71%. Se encontraron asociaciones significativas entre ciertos factores de riesgo y la presencia de ITS, como la edad de inicio de la actividad sexual y el número de parejas sexuales. Conclusiones: Se detectó alta prevalencia de patógenos responsables de ITS en mujeres con cuadro clínico, resaltando la importancia del diagnóstico molecular para detección temprana y precisa. Palabras clave: Infección de Transmisión Sexual, Factores de riesgo, PCR, Prevalencia.
Healthcare workers' and students' knowledge regarding the transmission, epidemiology and symptoms of COVID-19 in 41 cities of Bolivia and Colombia
(Elsevier BV, 2020) Juan Pablo Escalera-Antezana; Pedro Ezequiel Cerruto-Zelaya; Mijael Apaza-Huasco; Sarah Herminia Miranda-Rojas; Carlos Alfredo Flores-Cárdenas; Luisa Rivera-Zabala; Julia Rosa Olmos-Machicado; Valeria Álvarez‐Amaya; Doménica Acevedo-López; Valentina Valencia-Gallego
Incidence of SARS-CoV-2/COVID-19 in military personnel of Bolivia
(BMJ, 2020) Juan Pablo Escalera-Antezana; C A Mariaca-Cerball; Lucia Elena Alvarado-Arnez; María Alejandra Balderrama-Saavedra; D. Katterine Bonilla‐Aldana; Alfonso J. Rodríguez‐Morales
The impact of COVID-19 has not been described so far in a military setting, especially in Latin America.[1][1] Latin America has recently become the main epicentre of the pandemic due to the significant rise in the number of cases in Brazil and other countries in the region, accounting for more than
Infectious diseases prevention and vaccination in migrants in Latin America: The challenges of transit through the treacherous Darien gap, Panama
(Elsevier BV, 2025) Alfonso J. Rodriguez-Morales; María Camila Puerta-Arias; Rola Husni; Juan José Montenegro-Idrogo; Juan Pablo Escalera-Antezana; Lucia Elena Alvarado-Arnez; D. Katterine Bonilla‐Aldana; Germán Camacho‐Moreno; Henry Mendoza; Ivan Arturo Rodriguez-Sabogal
Is Plague Globally Reemerging?
(Elsevier BV, 2018) Alfonso J. Rodríguez‐Morales; Juan Pablo Escalera-Antezana; Lucia Elena Alvarado-Arnez
Is Plague Globally Reemerging?
Latin America: Situation and preparedness facing the multi-country human monkeypox outbreak
(Elsevier BV, 2022) Alfonso J. Rodríguez‐Morales; Gustavo Lopardo; Sergio Verbanaz; Tomás Orduña; Susana Lloveras; Jose María Azeñas-Burgoa; Juan Pablo Escalera-Antezana; Lucia Elena Alvarado-Arnez; Alexandre Naime Barbosa; Fredi Alexander Díaz-Quijano
Fundación Universitaria Autónoma de las Américas. Faculty of Medicine. Grupo de Investigación Biomedicina. Pereira, Risaralda, Colombia / Universidad Científica del Sur. Master of Clinical Epidemiology and Biostatistics. Lima, Peru / Latin American network of Monkeypox Virus Research. Pereira, Risaralda, Colombia
<strong>Ageusia and Anosmia, a Common Aign of COVID-19? A Case Series from Four Countries</strong>
(2020) Jair Vargas-Gandica; Daniel Winter; Rainer Schnippe; Andrea G. Rodriguez‐Morales; Johana Mondragon; Juan Pablo Escalera-Antezana; María del Pilar Trelles-Thorne; D. Katterine Bonilla‐Aldana; Alfonso J. Rodríguez‐Morales; Alberto Paniz‐Mondolfi
Over the course of the pandemic due to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), multiple new clinical manifestations, as the consequence of the tropism of the virus, have been recognized. That includes now the neurological manifestations and conditions, such as headache, encephalitis, as well as olfactory and taste disorders. We present a series of ten cases of RT-PCR confirmed SARS-CoV-2 infected patients diagnosed with viral-associated olfactory and taste loss from four different countries.
Organisms of Concern But Not Foodborne or Confirmed Foodborne: Bolivian Hemorrhagic Fever Virus (Machupo Virus)
(Elsevier BV, 2019) Alfonso J. Rodríguez‐Morales; D.M. Castañeda-Hernández; Juan Pablo Escalera-Antezana; Lucia Elena Alvarado-Arnez
Oropouche Fever in Beni, Bolivia, 2024
(Elsevier BV, 2025) Juan Pablo Escalera-Antezana; Rodrigo Daniel Montesinos-Jove; Carlos Eduardo Gonzales-Flores; Claudia Nathaly Arauco-Gutierrez; Jorge Luis Aviles-Sarmiento; Claudia Marcela Montenegro-Narváez; Hugo Antonio Castro-Calderón; Nestor Freddy Armijo-Subieta; Alfonso J. Rodríguez‐Morales
Orthohantavirus pulmonary syndrome in Santa Cruz and Tarija, Bolivia, 2018
(Elsevier BV, 2019) Juan Pablo Escalera-Antezana; Roberto Torrez-Fernandez; Dagner Montalvan-Plata; Claudia Marcela Montenegro-Narváez; Jorge Luis Aviles-Sarmiento; Lucia Elena Alvarado-Arnez; D. Katterine Bonilla‐Aldana; Alfonso J. Rodríguez‐Morales