Browsing by Autor "Juan Pedro Arrebola"

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Associations of maternal o,p′-DDT and p,p′-DDE levels with birth outcomes in a Bolivian cohort
(Elsevier BV, 2016) Juan Pedro Arrebola; Miriam Cuellar; Jens Peter Bonde; Beatriz González-Alzaga; L.A. Mercado
Concentrations of organochlorine pesticides and polychlorinated biphenyls in human serum and adipose tissue from Bolivia
(Elsevier BV, 2011) Juan Pedro Arrebola; Miriam Cuellar; E. Claure; M. Quevedo; S.R. Antelo; E Mutch; E. Ramirez; Mariana F. Fernández; Nicolás Olea; L.A. Mercado
Contribution of sociodemographic characteristics, occupation, diet and lifestyle to DDT and DDE concentrations in serum and adipose tissue from a Bolivian cohort
(Elsevier BV, 2011) Juan Pedro Arrebola; E Mutch; M. Rivero; A. Choque; Sara Di Silvestre; Nicolás Olea; Ricardo Ocaña‐Riola; L.A. Mercado
Factors influencing combined exposure to three indicator polychlorinated biphenyls in an adult cohort from Bolivia
(Elsevier BV, 2012) Juan Pedro Arrebola; E Mutch; Miriam Cuellar; M. Quevedo; E. Claure; López Mejía; María Fernández-Rodríguez; Carmen Freire; Nicolás Olea; L.A. Mercado
Human exposure to DDT/DDE in Santa Cruz De La Sierra (Bolivia). A gender perspective
(Elsevier BV, 2010) Juan Pedro Arrebola; Miriam Cuellar; E. Claure; M. Quevedo; R. Antelo; Nicolás Olea; L.A. Mercado
Prenatal exposure to organochlorine pesticides and birth outcomes in Bolivia
(National Institute of Environmental Health Sciences, 2016) Juan Pedro Arrebola; Miriam Cuellar; Jens Peter Bonde; Beatriz González-Alzaga; L.A. Mercado
The use of pesticide DDT and other organochlorine pesticides has been relatively recently banned in Bolivia and, furthermore, and there are evidences of illegal trade in the country. Our research group has identified highly exposed population subgroups in recent biomonitoring studies performed in Eastern Bolivia. Furthermore, we found evidences of the potential impact of prenatal exposure to DDT and its main metabolite p,p´-DDE on birth anthropometric measures and gestational length in a mother-child cohort recruited in Santa Cruz de la Sierra. Interestingly, the pattern of exposure was somewhat different than most of the previously studied cohorts, with o,p´-DDT detected in 82.5% of samples at median concentration of 0.22, and p,p´-DDE in 86.5% of samples at median concentration of 1.01 ng/mL. Opposite associations with birth weight were found for p,p´-DDE (β=0.012, p=0.006) and o,p´-DDT (β=-0.014, p=0.039), and these associations were stronger when both chemicals were entered in the same model. p,p´-DDE was negatively associated with gestation time (β=-0.004, p=0.012), and o,p´-DDT was borderline negatively associated with newborn head circumference (β=-0.004, p=0.054). We observed no relevant changes in the magnitude of the coefficients or in statistical significance after adjustment for TSH levels. This study indicates a possible impact of prenatal exposure to o,p´-DDT and p,p´-DDE on newborn anthropometric measurements in a population showing evidence of recent exposure to the pesticide DDT.
S07-3 Occupational exposure to persistent pesticides amongst agricultural workers in bolivia
(2016) Juan Pedro Arrebola; E Mutch; M. Rivero; A. Choque; Sara Di Silvestre; Nicolás Olea; Ricardo Ocaña‐Riola; LA Mercado
<h3>Background</h3> Organochlorine pesticides are still used for vector control, and there is evidence of their recent illegal use in agriculture in several tropical and subtropical areas of South America, including Bolivia. <h3>Objectives</h3> To determine concentrations of three selected organochlorine pesticides (p,p’-DDT, p,p’-DDE, HCB) in adipose tissue and serum samples in several Bolivian population sub-groups. <h3>Results</h3> We found relatively high exposure levels in several Bolivian population groups, influenced by different factors from those observed in Europe and North America due to their specific occupational, lifestyle and dietary patterns. Especially elevated p,p’-DDE (main DDT metabolite) exposure levels were found in agricultural farmers from three rural communities in eastern Bolivia (subtropical area), with median serum concentrations of 19.7 ng/mL, which were 20-fold higher than those found in Bolivian urban dwellers. This is an alarming finding considering that this pesticide has been prohibited in the country since 1996. Additionally, multivariate models revealed a positive correlation between residence in the study area and exposure levels. <h3>Conclusion</h3> Our results point to the existence of heavily-polluted and previously unidentified hotspots in the region, underlining the need for the continuous monitoring of these populations given the potential associated health risks.
Serum concentrations of p,p′-dichlorodiphenyltrichloroethane (p,p′-DDE) in a sample of agricultural workers from Bolivia
(Elsevier BV, 2013) L.A. Mercado; Sara M. Freille; Jasmin S. Vaca-Pereira; Miriam Cuellar; Lizbeth Flores; Elaine Mutch; Nicolás Olea; Juan Pedro Arrebola