Browsing by Autor "Juliana Quintero"

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    Long-term dynamics of natural, vaccine-induced, and hybrid immunity to SARS-CoV-2 in a university hospital in Colombia: A cohort study
    (2024) Nohemí Caballero; Diana M. Monsalve; Yeny Acosta‐Ampudia; Natalia Fajardo; Sergio Moreno; Oscar Martínez; Catalina González-Uribe; Carolina Ramı́rez-Santana; Juliana Quintero
    <title>Abstract</title> This prospective cohort study aimed to estimate the natural, vaccine-induced, and hybrid immunity to SARS-CoV-2, alongside the immunogenicity of the mRNA-1273 booster after the BNT162b2 primary series in healthcare workers in Colombia. IgG, IgA, and neutralizing antibodies were measured in 110 individuals with SARS-CoV-2 infection or a BNT162b2 primary series. Humoral responses and related factors were explored in a subgroup (n = 36) that received a BNT162b2 primary series followed by a mRNA-1273 booster (2BNT162b2 + 1mRNA-1273), and T-cell responses were evaluated in a subgroup of them (n = 16). For natural immunity, IgG and IgA peaked within three months, declining gradually but remaining detectable up to 283 days post-infection. Neutralizing antibody inhibition post-infection was below positive range (≥ 35%) but exceeded 97% in vaccine-induced and hybrid immunity groups. Following 2BNT162b2 + 1mRNA-1273, IgG peaked 3–4 months post-booster, gradually declining but remaining positive over 10 months, with IgA and neutralizing antibodies stable. Age and blood group were related to IgG response, while obesity and blood type to IgA response post-booster. Autoimmunity and blood type B were associated with lower neutralizing antibody inhibition. There were no differences in T-cell responses according to prior infection. These findings provide long-term insights into the immunity against SARS-CoV-2 and the immunogenicity of mRNA vaccines.
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    SISCOVID: modelos de sistemas complejos para contribuir a disminuir la transmisión de SARS-COV-2 en contextos urbanos de Colombia
    (Universidad de Los Andes, 2020) Felipe Montes; José D. Meisel; Pablo Lemoine; Diana R. Higuera; Andrés F. Useche; Sofía del C. Baquero; Juliana Quintero; Diego A. Martínez; L. Idrobo Idrobo; Ana M. Jaramillo
    The development and implementation of strategies to reduce SARS-CoV2 transmission is a prevailing challenge for Colombia. These strategies ought to be dynamic and specific to each region, seeking to balance health and economic impacts. This task calls for an interdisciplinary approach to ensure a holistic view of the problem. This article presents findings and results obtained from the SISCOVID project, which used simulated systemic models to support decision making and efforts to mitigate the pandemic in Colombia. The project included researchers from Universidad de Los Andes, the Centro Nacional de Consultoría (CNC) and Universidad de Ibagué, in alliance with several international universities and companies. SISCOVID helped decision makers design strategies to reduce SARS-CoV-2 transmission in urban contexts for the cities of Barranquilla, Bogotá, Cali, Cartagena, and Medellín.
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    Two Outbreaks that Exposed the Scope of Socioeconomic Inequalities in Latin America: Inequities in Dengue and Covid-19 in 42 Latin American Cities
    (RELX Group (Netherlands), 2025) Mabel Carabali; Usama Bilal; Luz Mery Cárdenas Cárdenas; Juliana Quintero; Arjumand Siddiqi; Waleska Teixeira Caiaffa; Ana V. Diez–Roux