Browsing by Autor "Karin Herrera"

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    Can we rely on the orocecal transit time measured by the lactulose breath test? Simultaneous measurement of Tc99m colloid scintigraphy and lactulose breath hydrogen test in asymptomatic volunteers
    (Research Square (United States), 2024) Christian von Mühlenbrock; Glauben Landskron; Teresa Massardo; Pablo Tomás Muñoz; Karin Herrera; Ana María Madrid
    <title>Abstract</title> INTRODUCTION: The measurement of orofecal transit time (OCTT) has various challenges; its calculation through the detection of hydrogen in exhaled air with lactulose (H2 breath test), a non-invasive and widely used technique, is controversial and not validated in the local population. AIM: To demonstrate the correlation between techniques for measuring OCTT through the simultaneous use of intestinal scintigraphy with radiolabeled colloid (OCTT-R) and lactulose breath hydrogen test (OCTT-H2). METHOD: Healthy volunteers over 18 years old underwent a 12-hour fast, followed by oral administration of colloid sulfur mixed with lactulose. Simultaneously, abdominal images were obtained using a gamma camera, and breath samples were collected every 10 minutes for 180 minutes. The lactulose orocecal transit time (OCTT-H2) was considered when the curve elevation exceeded 20 ppm above the baseline value, after the first 60 minutes of the study. The orocecal transit time with radioisotopes (OCTT-R) corresponding to 50% activity of the tracer administered in the cecum was quantified. RESULTS: Seventeen patients aged between 22 and 77 years (82% women) were included. OCTT-R varied between 73 and 180 minutes and OCTT-H2 between 60 and 130 minutes. OCTT-R with radioisotopes and OCTT-H2 showed a good correlation (r: 0.794; 95% CI: 0.508 - 0.923). Results of orocecal transit time with radioisotopes versus H2 did not have significant differences (p= 0.959). CONCLUSION: OCTT-H2 is feasible to measure using lactulose as a substrate with a good correlation and no difference with isotopic technique.­­­
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    Desafíos en la adherencia a STRIDE-II: perspectivas de gastroenterólogos y pacientes con enfermedad inflamatoria intestinal
    (Elsevier BV, 2025) Francisca Carvajal; Karin Herrera; Paulina Núñez; Lilian Flores; Andrea Córdova; Gonzalo Pizarro; Pamela San Martín; Rodrigo Quera