Browsing by Autor "Karla Y. Acosta-Viana"

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    Leishmanicidal Activity and Immunomodulatory Effect of a Mixture of Lupenone and β-Caryophyllene Oxide
    (Springer Science+Business Media, 2021) Glendy Polanco-Hernández; Alberto Giménez-Turba; Efraín Salamanca; Giulia Getti; Rajeev Rai; Karla Y. Acosta-Viana; Víctor Ermilo Arana‐Argáez; Julio César Torres‐Romero; Karla Fernández-Martín; Maira Rubí Segura Campos
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    Synergistic Effect of Lupenone and Caryophyllene Oxide against<i>Trypanosoma cruzi</i>
    (Hindawi Publishing Corporation, 2013) Glendy Polanco-Hernández; Fabiola Escalante‐Erosa; Karlina García‐Sosa; María E. Rosado; Eugenia Guzmán-Marı́n; Karla Y. Acosta-Viana; Alberto Giménez-Turba; Efraín Salamanca; Luis M. Peña-Rodrı́guez
    The in vitro trypanocidal activity of a 1 : 4 mixture of lupenone and caryophyllene oxide confirmed a synergistic effect of the terpenoids against epimastigotes forms of T. cruzi (IC50 = 10.4 μ g/mL, FIC = 0.46). In addition, testing of the terpenoid mixture for its capacity to reduce the number of amastigote nests in cardiac tissue and skeletal muscle of infected mice showed a reduction of more than 80% at a dose level of 20.8 mg·kg(-1)·day(-1).