Browsing by Autor "L. Cudkowicz"

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Cardio-respiratory studies in chronic mountain sickness (Monge's syndrome)
(Elsevier BV, 1977) L. Cudkowicz; J. Ergueta; Hilde Spielvogel
Cardio-Respiratory Studies in Chronic Mountain Sickness (Monge’s Syndrome)
(Karger Publishers, 1971) J. Ergueta; Hilde Spielvogel; L. Cudkowicz
Comparisons with 14 normal, younger, male native residents of La Paz showed that 20 patients with Monge’s syndrome have significantly higher mean body surface areas, hemoglobin, resting tidal volumes [VT (BTPS)], and resting minute volumes [VE (BTPS)]. If [VE (BTPS) is subdivided into its components of alveolar [Va (BTPS)] and dead space ventilations [VDS (BTPS)], it becomes apparent that the former is significantly smaller and the latter much larger in the Monge patients than in the controls. Alveolar hypoventilation in the Monge group is evidenced by an elevated mean PaCO2; a lower mean pH of 7.349, contrasted with that of 7.399 in the controls; a PaO2 of 48.1 mm Hg, compared with 57.7 mm Hg in the normals. Simultaneous surface scanning of the right upper and lower lung zones, using a central venous injection of 131I-HSA (human iodinated serum albumin), showed a reduction of total isotope activity in the right upper zones of the Monge group.
Erythropoietin and the Polycythemia of High-Altitude Dwellers
(Springer Nature, 1989) Nicholas Dainiak; Hilde Spielvogel; S Sorba; L. Cudkowicz
Pulmonary Diffusing Capacity in Young Andean Highland Children
(Karger Publishers, 1982) Enrique Vargas; John Beard; Jere D. Haas; L. Cudkowicz
Lung diffusing capacities for carbon monoxide were measured in 125 highland Andean children between 4 and 6 years of age in La Paz, Bolivia (3,650 m), using a steady-state technique. Male children had a significantly lower DLC0 (13.2 ± 2.7) compared to females (14.2 ± 1.9; p < 0.05), despite similar body size Hemoglobin concentration was significantly greater than published values for low-altitude children and this also changes pulmonary diffusing capacities and supports the concept of early developmental adaptation in pulmonary function to environmental stressors as well as a sexual dimorphism in this type of adaptation.
Regional Distribution of Pulmonary Blood Flow in Normal High-Altitude Dwellers at 3,650 m (12,200 ft)
(Karger Publishers, 1975) J Coudert; M Paz-Zamora; L. Barragán; L Briançon; Hilde Spielvogel; L. Cudkowicz
Simultaneous isotope dilution curves were recorded from the right upper (QRUZ) and right lower lung zones (QRLZ) by surface scanning in the sitting and recumbent positions in 15 normal high-altitude-born (HAD) males and in 1 HAD female as well as from 3 male newcomers, using 10 muCi of 131I-HSA as a bolus injection into the right ventricle. Similar information was also obtained at sea level from 5 normal males. The mean percent distribution of total pulmonary blood flow (Q) to RUZ and RLZ in the two body postures indicate (1) that in the vertical position RUZ in males receives about 17% of Q regardless of altitude and elevation in mean pulmonary artery pressure (MPAP) in HAD of 8.6 mm Hg above that extant at sea level; (2) recumbency at high altitude showed QRUZ also to be lower than at sea level; (3) elevation in MPAP at altitude has no significant effect on changing the sea-level distribution pattern of pulmonary blood flow.
Respiratory Studies in Women at High Altitude (3,600 m or 12,200 ft and 5,200 m or 17,200 ft)
(Karger Publishers, 1972) L. Cudkowicz; Hilde Spielvogel; G. Zubieta
At two altitudes (3,600 and 5,200 m), resident native women (A) showed higher PAco2 and Paco2, lower PAO2 and PaO2, as well as lower arterial pH, than native males (C) of similar age. Resting minute ventilation (VE/m2), tidal volume (VT) and respiratory frequency (f) were similar. The differences in the alveolar-arterial gas tensions in A stem from larger dead space (VDS), VDS/VT and reduced alveolar ventilation (VA). Newcomer females (B) at both altitudes differed from new- comer males (D) in regard to larger resting VA, f and smaller VT. No differences were demonstrated in size of VDS, VDS/VT or VO2/BSA; but PAco2 and PacO2 were lower, PAO2 and Pa higher and VE/VO2 and VA/VO2 (ventilatory equivalents) above those for resting newcomer males. A contrasted with resting B at 3,600 m (12,200 ft), showing higher PAco2 and Paco2, lower Pao2 and arterial pH, reduction in VA and larger VDS/VT. Both C and D at 3,600 and 5,200 m during steady-state 60-W (367 kg/m/min) exercise showed lower PAco2 and Paco2, higher arterial pH, smaller VDS and higher VE/VO2 than exercising A. The latter differed from C exercising at the same work load in that VE/m2 and VA were reduced, PAco2 and Paco2 were higher, Pa-ao2 gradients were wider, pH was lower and VDS as well as VDS/VT were larger. Contrasted with B during steady-state 60-W exercise at both altitudes, D showed consistently smaller VDS and larger VA. While both C and A had higher resting f than D, f of newcomer females at La Paz was higher than that of A. Control of ventilation by relating VE to Pao2 and Paco2 at rest and exercise at both altitudes showed marked attenuation of hypoxic and hypercapnic drives, particularly in the native resident female, suggesting diminished peripheral chemoreceptor function.
The Effects of High Altitude on Pulmonary Hypertension of Cardiopathies, at La Paz, Bolivia
(Karger Publishers, 1969) H. Spievogel; L. Otero-Calderon; Gustavo Calderón; Ralph Hartmann; L. Cudkowicz
The regional distribution of pulmonary blood flow in normal high altitude dwellers at 3650 m (12,200 ft) and in chronic mountain sickness
(Elsevier BV, 1977) L. Cudkowicz; J Coudert; M Paz-Zamora; L. Barragán; L Briançon; Hilde Spielvogel; Nicanor Machicao; Magda Karina López Saldaña