Browsing by Autor "Lenys Buela"

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Efecto de la combinación fija de Vildagliptina/Metformina o Sitagliptina/Metformina sobre la lipemia postprandial en pacientes con diabetes tipo 2
(2012) María Alejandra Vergel Yaruro; Alba Salas Paredes; Lenys Buela; Lenín Valeri; Gabriela Arata-Bellabarba; Elsy Velázquez-Maldonado
Objective: to assess the effect of fixed combination of vildagiptin/metformin and sitagliptina/ metformin on postprandiallipemia (PP) in patients with type 2 diabetes mellitus (DM2). Methods: fifty-seven patients with DM2 previously treated with metformin and diet and HbA1c between 6,5-8,5% participated in a 8 weeks randomized, double blind study. An oral fat load was performed at baseline and 8 weeks after treatment with fixed combination of vildagliptin/metformin (grupo 1; n=29) or sita gliptin/metformin (group 2; n=28) twice a day. Blood samples were taken at baseline and at 2 hours interval during 8 hours after oral fat load. Results: integrated postprandial triglyceride response (AUC-TG) decreased in 76% of patients of group 1 and 64% of group 2. Fasting lipoprotein profile did not show significant changes post treatment. Both fasting and 2h postprandial glucose and HbA1c showed a significant decrease in both groups, in association with a decrease of body mass index and blood pressure (p<0,001). No adverse effects were observed. Conclusions: besides improving glucose control, fixed combination of vildagliptin/metformina or sita gliptina/metformin treatment has a beneficial effect postprandial lipemia which is important to improve the cardiometabolic risk of type 2 patients.
Índice trigliceridos/cHDL en el embarazo: Interrelación con índices de resistencia a la insulina y antropometría fetal
(2013) Ana Victoria Becerra Leal; Alba Salas Paredes; Lenys Buela; Maria Alejandra Sosa; Gabriela Arata-Bellabarba; Lenín Valeri; Elsy Velázquez-Maldonado
Objective: to determine the relationship between triglycerides/high density lipoprotein cholesterol (TG/HDLc) index and indexes HOMAIR (Homeostasis Model assessment) y QUICKI (Quantitative Insulin Sensitivity Check Index) and fetal anthropometrics in healthy pregnant women. Methods: This cross-sectional study evaluated 91 healthy pregnant women aged 16-41 yr, categorized by gestational age: first trimester (TI, n = 29); second trimester (TII, n = 32); third trimester (TIII, n = 30). Oral glucose tolerance test (75g) was performed. Plasma concentrations of glucose, insulin, triglyceride (TG), total cholesterol (TC) and HDLc were measured. Low density lipoprotein cholesterol (LDLc), no-HDLc, TG/HDLc index, HOMA IR and QUICKI were calculated. Fetal abdominal circumference (FAC) and estimated fetal body weight (EFBW) were evaluated by abdominal ultrasound; uterine height (UH), blood pressure and birth weight were registered. Results: Mean plasma TG, total cholesterol, LDLc, no-HDLc and TG/HDLc, HOMA IR and QUICKI indexes were significantly higher in TII and TIII compared to TI. In all women analysis, both TG/HDLc and no-HDLc showed a significant correlation with pregestational body mass index (BMI) (r = 0.30, p<0,01; r = 0,26, p<0,05 respectively), FAC (r= 0,38, p<0,05; r = 0,50,, p<0,01 respectively), EFBW (r = 0,39, p<0,01; r = 0,50, p<0,05 respectively) and UH (r= 0,485, p<0,001).
Interrelación de índices de resistencia y sensibilidad a la insulina con variables antropométricas y metabólicas de mujeres del tercer trimestre de embarazo y recién nacido a término
(2015) Alba Salas Paredes; Secundino A Galicia Colina; María Alejandra Sosa Peña; Gabriela Arata-Bellabarba; Lenys Buela; Elsy Velázquez-Maldonado
objective: To evaluate the relationship between insulin resistance and sensibility indexes with anthropometrics and metabolic parameters in third trimester of pregnant women and normal term newborns.