Browsing by Autor "Lilian Pinto"

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Clinical and immunological characteristics of tegumentary leishmaniasis cases in Bolivia
(Public Library of Science, 2021) Cristina Ballart; Mary Cruz Torrico; Gisela Vidal; Faustino Torrico; Daniel Lozano; Montserrat Gállego; Lilian Pinto; Ernesto Rojas; Ruth Aguilar; Carlota Dobaño
In Bolivia, parasitological diagnosis remains the reference standard in diagnosis of leishmaniasis because of its high specificity, whereas the sensitivity varies over a wide range leading to loss of cases. Until more accurate tools are implemented, all patients should be tested by both smears and culture of lesion aspirates to minimize the risk of false negatives. Our results showed higher concentrations of several cytokines in MCL compared to CL, but no differences were observed between CL and no-cases. In addition, none of the cytokines differed between primary and secondary infections. These results highlight the need of further research to identify biomarkers of susceptibility and disease progression, in addition to looking at the local cellular immune responses in the lesions.
Development and Evaluation of a Three-Dimensional Printer–Based DNA Extraction Method Coupled to Loop Mediated Isothermal Amplification for Point-of-Care Diagnosis of Congenital Chagas Disease in Endemic Regions
(Elsevier BV, 2020) Diana P. Wehrendt; Julio Alonso-Padilla; Bo Liu; Lizeth Rojas Panozo; Silvia Rivera Nina; Lilian Pinto; Daniel Lozano; Albert Picado; Marcelo Abril; María‐Jesús Pinazo
Evaluation and validation of a PrintrLab-based LAMP assay to identify Trypanosoma cruzi in newborns in Bolivia: a proof-of-concept study
(Elsevier BV, 2024) Lizeth Rojas Panozo; Silvia Rivera Nina; Diana P. Wehrendt; Aina Casellas; Lilian Pinto; Susana Méndez; Chi-Wei Kuo; Daniel Lozano; Lourdes Ortiz; María‐Jesús Pinazo
Inter-American Development Bank.
Five-year serological and clinical evolution of chronic Chagas disease patients in Cochabamba, Bolivia
(Public Library of Science, 2023) Jimy Pinto; Malia Skjefte; Julio Alonso-Padilla; Daniel Franz Lozano Beltrán; Lilian Pinto; Aina Casellas; Mery Elena Arteaga Terrazas; Karen Galindo; Roxana Challapa Quechover; María Escobar Caballero
The study confirms that follow-up of benznidazole-treated T. cruzi-infected patients should be longer than five years to determine, with current tools, if they are cured. In terms of serological evolution, the single use of a total antigen ELISA might be a more reliable measure and suffice to address infection status, at least in the region of Bolivia where the study was done. Additional work is needed to develop a test-of-cure for an early assessment of drugs´ efficacy with the aim of improving case management protocols.
Molecular detection and parasite load of Trypanosoma cruzi in digestive tract tissue of Chagas disease patients affected by megacolon
(Elsevier BV, 2022) Lilian Pinto; Alejandro G. Schijman; Julio Alonso-Padilla; Daniel Lozano; Mary Cruz Torrico; Pietro Gamba; Margarita Torrez; Vania Lozada; Karina Cartagena; Jareth Sánchez