Browsing by Autor "Lisbeth Sosa"

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Análogo de tejido conectivo a partir de fibroblastos gingivales sembrados en membranas de colágeno comercial
(2013) Daniela Andreina Olávez Cepeda; Lisbeth Sosa; Karla Andreína Padrón Durán; Siham Salmen; Lisbeth Berrueta; B Lorena Dávila; Gladys Josefina Velazco Viloria; A Susana Arteaga; Leonel Castillo; N Eduvigis Solórzano
Modern dentistry using guided tissue regeneration and tissue engineering in periodontal defects and gingival recession treatment, applying surgical techniques such autologous grafts have shown excellent results. The objetive was to determine the efficiency of gingival connective tissue analogs, obtained from cultured fibroblasts seeded on a commercial collagen scaffold, for grafting in Wistar rats induced gingival recession. The methodology Connective tissue analog was developed sowing a human gingival fibroblasts culture on a collagen scaffold Membracel®-O, at the same time it was induced a 2 mm gingival recession in the central incisors of three Wistar rats, lifting a Newman flap to create a marginal bone dehiscence; 45 days after, the connective analog graft was inserted in rat 2, rat 3 received a Membracel ®-O graft without cells and rat 1 didn’t received any graft leaving it as a control, finally the animals were clinically evaluated every week before euthanasia. The results: Rat 1 maintained the 2mm gingival recession, rat 2 achieved an insertion gain of 2 mm also presenting increased biotype and rat 3 presented a 1.5 mm gingival recession. It can be suggested that using Membracel ®-O to produce connective tissue analogues may be an alternative to gingival recession treatment since insertion gain was achieved with no evidence of clinical signs of rejection.
Análogo de tejido conectivo injertado en recesiones gingivales inducidas en ratas Wistar
(Universidad de Los Andes, 2017) Karla Andreína Padrón Durán; B Lorena Dávila; Daniela Andreina Olávez Cepeda; Siham Salmen; Lisbeth Sosa; A Susana Arteaga; P Rosalba Florido; N Eduvigis Solórzano
Mucogingival surgery aim is to prevent or treat anatomical, pathological and traumatic gingival defects, such as gingival recession, which cause functional aesthetic and biological difficulties. To treat them, it’s been developed, tissue substitutes obtained from gingival connective cells of the patient. The purpose of this study is to determine the effectiveness of an analogue connective tissue developed from human gingival fibroblasts, by the treatment of induced gingival recession. 24 male Wistar rats were selected, the periodontal clinical examination was carried out and gingival recession in right central upper incisor was induced; then after cicatrization it was made a flap to place the analog connective tissue graft obtained from a culture of human fibroblasts, in animals of group I, group II received a collagen scaffold without cells and group III were left without graft. The study results showed that 86.66% of the animals in group I had a 2mm insertion gain, while 13.3% won 1.5mm insertion. 86% of the animals of group II won 1mm insertion, and group III had not showed insertion gain, instead they remained with 2mm recession. In conclusion the gingival graft from a fibroblast cell culture can be considered as a viable alternative to achieve root coverage, and even increase the width of attached gingiva and thickness of periodontal biotype.
Aplicación subgingival de melatonina en eltratamiento de la periodontitis
(Universidad Internacional de La Rioja, 2020) Ana Campos; Yokasta Ramos; Lisbeth Sosa; Karla Andreína Padrón Durán; M C Nuvia Sánchez
to assess the effectiveness of the subgingival application of melatonin as a coadjuvant in the treatment of chronic periodontitis. Materials and methods: The design of this research was experimental, 6 patients were selected between 22 and 47 years with moderate to severe chronic periodontitis, the applied treatment was carried out by the split mouth design, it was divided into control side where it was performed scaling and root planing (RAR) and experimental side where RAR was performed and synthetic melatonin was applied using autologous gel as plasma vehicle. Subsequent evaluations were made at 8, 15 and 45 days. Subsequently, a descriptive analysis was carried out and the student t test was used. Results: It was found that melatonin produced clinical changes in the gingiva, reducing the signs of inflammation in the texture (from 85% to 15%), consistency (from 45% to 0%) and color (from 85% to 15%) of the experimental group. There was also a decrease in the gingival index of the experimental group (from 1.83 to 0.54) with respect to the control group (from 1.88 to 1.34). And lower levels of hemorrhage in the experimental group (from 1.85 to 0.54) unlike the control group (from 1.63 to 1.75). Conclusion: subgingival melatonin can potentiate the effects of conventional therapy so it is recommended to conduct more studies on the subject.
Cambios clínicos periodontales ocasionados por el chimó en animales de experimentación
(2008) Ana Julia Rosales; Lisbeth Sosa; B Lorena Dávila; J M Belkis Quiñonez; J R Patricio Jarpa
El chimo es un derivado del tabaco utilizado en Venezuela el cual contiene nicotina. Su inocuidad ha sido puesta en duda por los danos que podria causar en los tejidos periodontales. El proposito de esta investigacion es estudiar los cambios clinicos que puede ocasionar el chimo en los tejidos periodontales de animales de experimentacion. Se seleccionaron 22 ratas macho de la cepa Wistar, 11 constituyeron el grupo control y 11 el experimental. Se aplico al control solucion fisiologica y al experimental chimo, en una solucion de 18 g/5 ml (chimo/solucion fisiologica), ambos por via topica (frotacion). Frecuencia de aplicacion: 3 dias a la semana, durante 20 semanas. El grupo control no mostro cambios. El grupo experimental presento disminucion del puntillado de la encia y cambios en la consistencia de la misma en un 90%, isquemia y aumento del grado de queratinizacion 100%, recesiones gingivales 63%, sacos periodontales en un 36%, lesiones blancas y rojas en un 28%. Los cambios clinicos observados estan directamente relacionados con el tiempo de exposicion al chimo.
Carcinoma de células escamosas moderadamente diferenciado en cavidad bucal. Reporte de un caso
(2017) Elsy Jerez; B Lorena Dávila; Lisbeth Sosa; José Leonel Castillo Cáceres; Jenair del Valle Yépez Guillén
La lesion maligna mas frecuente en cavidad oral es el carcinoma de celulas escamosas, que representa el 90% de las lesiones malignas en boca. Este articulo tiene como objetivo reportar el caso de un paciente de 51 anos de edad que acudio a la Clinica de Periodoncia de la Facultad de Odontologia de la Universidad de los Andes presentando una lesion con perdida de tejidos en la zona correspondiente a las unidades dentarias 12 y 13, de bordes poco definidos, de color rojiza, con zonas blanquecinas no desprendibles, muy doloroso a la palpacion. Se tomo una biopsia incisional de la lesion y el resultado histopatologico reporto Carcinoma de Celulas Escamosas Moderadamente Diferenciado. Es importante la valoracion clinica, radiografica y la indicacion de examenes complementarios asi como la toma de biopsia de cualquier lesion sospechosa a pacientes que puedan considerase en grupos de alto riesgo de padecer este tipo de lesiones malignas y establecer un diagnostico diferencial, para luego tener un diagnostico definitivo mas adecuado del caso y establecer el mejor plan de tratamiento, como se describio en este
Cátedra de Periodoncia. Departamento de Medicina Oral.
(2015) B Lorena Dávila; Lisbeth Sosa; Johelsy Infante; A Susana Arteaga; Francisco Salvador Palacios
Psoriasis is a chronic inflammatory mucocutaneous disease that affects 2% of the population. Cutaneous lesions appear as erythematous plaques localized or generalized papules covered with white scales hyperkeratotic, oral manifestations and irregular erythematous lesions with elevated white borders, ulcerations and desquamative gingivitis. It may be asymptomatic or cause pain, burning and sensation of roughness. Its etiology is unknown, although the interaction between the immune system and environmental factors may activate T cells skin, epidermal keratinocytes, with increased cytokine and tumor necrosis factor (TNF). The objective is to provide clinical evidence on the periodontal manifestations of patients with psoriasis, and reports a clinical case of a 62 year old male patient, who filed the anamnesis medical diagnosis of psoriasis, controlled systemically and presence of oral manifestations, was treated with mechanical therapy, periodontal and use of local antiseptics. At the end of 2 months of reassessment was a normal clinical characteristic of periodontal tissues. It was concluded that the oral lesions can present spontaneous remission or respond to systemic therapy, topical corticosteroids, mouthwash buccal or palliative therapy. Diagnosis and successful treatment that includes a proper control of dental plaque in patients with psoriasis allow control periodontal disease and reduce the appearance of severe injuries.
Cicatrización periodontal. Revisión de la literatura
(2017) Rodolfo Gutiérrez Palacios; Johelsy Infante; B Lorena Dávila; Lisbeth Sosa; Elsy Jerez
El tratamiento periodontal convencional involucra procedimientos quirurgicos y no quirurgicos que se emplean con el objetivo de mejorar las condiciones periodontales en el paciente, se busca principalmente posibilitar una neoformacion previsible de los tejidos de soporte dentario, es decir, del cemento radicular, el ligamento periodontal y el hueso alveolar. Es importante conocer el proceso de cicatrizacion de los tejidos periodontales para elegir la tecnica mas adecuada en cada caso, considerando los procesos biologicos que se desencadenan con la instrumentacion de las superficies radiculares. El objetivo de este articulo es presentar una revision bibliografica de los procesos de cicatrizacion que se producen en dientes naturales e implantes cuando se aplica una terapia periodontal convencional; en esta investigacion se realizo una busqueda computarizada de literatura en las bases de datos PubMed, Biblioteca virtual en salud, Cochrane Reviews, Lilacs ademas se realizo una busqueda manual en libros de periodoncia actualizados. Finalmente, se concluye que el clinico debe poseer conocimiento de la biologia periodontal, considerando las celulas del ligamento periodontal esenciales en la regeneracion periodontal.
Clasificación de las enfermedades y condiciones periodontales y periimplantares
(2020) Gredy Lugo; Caroll Yibrín; Lorena Dávila B.; Xiomara Gimenéz; Ilusión Romero; Tabatha Rojas; Johelsy Infante; Susana Arteaga; Lisbeth Sosa; María Palacios
Disease classification schemes are developed to facilitate the design and application of appropriate therapeutic strategies for each case, based on evidence from clinical trials. These schemes provide a framework for the scientific study of the etiology, pathogenesis, natural history and treatment of diseases and also offer a way to organize and execute individual treatment strategies. In the World Workshop of Periodontal and Peri-implant Diseases, held in 2017, an official classification system for priodontal and peri-implant diseases and conditions was agreed, which was published, later in 2018 in the two most prestigious journals in the area : Journal of Periodontology and Journal Clinical of Periodontology. This classification allows the development of frameworks to study the etiology, pathogenesis and treatment of periodontal and peri- implant disease, in addition to providing the international community with a way of communicating in a common language. The objective of this documentary review is to make the basic aspects of the new classification scheme for periodontal and peri-implant diseases and conditions available to Spanish speakers and dental professionals. The new classification system provides tools for the clinician to diagnose and treat the patient from the case definition, as well as to provide the scientist, researcher and epidemiologist with scientific bases to contribute to the development of new knowledge. However, this classification system is far from perfect and should be modified once there is enough new data to justify new revisions.
Efectividad del gel de manzanilla y llantén como terapia coadyuvante en el tratamiento de la periodontitis crónica
(2016) Susana Arteaga; B Lorena Dávila; Rodolfo Gutiérrez Palacios; Lisbeth Sosa; Génesis Albarrán; Marylenlid Isla; Néstor F. Díaz
Chronic periodontitis is an infectious disease affecting high prevalence of periodontal tissues, causing inflammation, clinical attachment loss and bone loss, slow progression. This experimental research, described the effectiveness of chamomile and plantain gel as adjunctive therapy in the treatment of chronic periodontitis. The sample consisted of 40 patients with this pathology, served in the clinic of Periodontology, School of Dentistry at the University of Los Andes (FOULA), Merida-Venezuela, divided into two groups: experimental and control. In addition to conventional periodontal therapy (tartar removal, scaling and root planing), held for both groups, the pilot was applied gel chamomile (5%) and plantain (2%), and the gel placebo control, both gels prepared by the department of Pharmaceutical Technology of the Faculty of Pharmacy and Bioanalysis, University of Los Andes. the depth of the periodontal pocket, gingival index (GI) bleeding index (HI) and index of O'Leary in both groups, before, during and evaluated after treatment. The study lasted for five weeks, with controls every eight days. The results were statistically analyzed using the chi square test, reflecting declines in both the index values (IG, IH and O'Leary) and the depth of periodontal pockets in the experimental group. When comparing the results of both groups found that the experimental group showed greater improvement in relation to the clinical characteristics than the control group, concluding that the gel chamomile and plantain with conventional therapy provides benefits in the recovery of periodontal health allowing periodontal tissues heal in a short time.
Efectos de la melatonina sobre los niveles creviculares de óxido nítrico en pacientes con periodontitis
(Universidad Internacional de La Rioja, 2021) Yokasta Ramos; Ana Campos; Lisbeth Sosa; Karla Andreína Padrón Durán; M C Nuvia Sánchez; Anajulia González; Élix Izarra
Periodontal disease occurs after the accumulation of dental biofilm, which generates an immunoinflammatory response producing oxidative stress and damage to the periodontium, with overproduction of free radicals and reactive species such as nitric oxide (NO). In this sense, melatonin, an antioxidant indolamine, can be an alternative to counteract these damages and promote periodontal healing. Therefore, the objective of this study was to evaluate the effectiveness of subgingival melatonin as an adjunct in the treatment of periodontitis. 6 patients with chronic periodontitis were selected; The sample was divided into the control side where scaling and root planing (RAR) were performed and the experimental side (RAR + plasma gel with melatonin). Gingival crevicular fluid (FCG) samples and probing depth measurements were taken. Post evaluations were made at 15 and 45 days. A descriptive analysis was carried out and the student's T test was used. Finding that NO levels decreased in the experimental group from 7.02 ± 3.29 µM to 2.51 ± 0.84 µM, with respect to the control group 2.28 ± 0.72 µM to 3.05 ± 1, 02 µM at 15 and 45 days respectively; the mean probing depth for the experimental group was 6.13mm to 3.80mm and for the control group 6.10mm to 4.50mm at the beginning and end of treatment. Local melatonin produces clinical changes in periodontal tissues with decreased nitrite levels in the experimental group, thus enhancing the effects of mechanical therapy.periodontitis; melatonin; antioxidant; nitric oxide
Enfermedad periodontal necrosante
(2020) Gredy Lugo; Xiomara Gimenéz; B Lorena Dávila; Ilusión Romero; Tabatha Rojas; Caroll Yibrín; A Susana Arteaga; Lisbeth Sosa; Johelsy Infante; Francisco Salvador Palacios
Acute periodontal diseases are rapid onset clinical conditions that involve the periodontium or associated structures and are characterized by pain or discomfort, tissue destruction and infection. In contrast to most other periodontal conditions, they can cause rapid destruction of periodontal tissues, thus emphasizing the importance of rapid diagnosis and treatment. Among these conditions, the following stand out necrotizing periodontal disease. According to the International Workshop for Classification of Periodontal Diseases and Conditions 2017 are two: Necrotizing gingivitis (NG) and Necrotizing periodontitis (NP). Necrotizing stomatitis (NE) is a more aggressive variation, which can be linked to the two entities mentioned. Necrotizing periodontal disease is an infection characterized by gingival necrosis, pain and gingival bleeding. It is considered to be an acute opportunistic gingival infection caused by dental biofilm. It appears more frequently in undernourished children and young with immunodeficiency. In its pathogenesis, there are factors related to the oral microbiota and factors associated with the host. Diagnosis is made by a clinical examination. The purpose of this study is to conduct a literature review of necrotizing periodontal disease. The clinical presentation, the course and the response to EPN therapy are specific among other periodontal diseases, so the existence of a particular clinical disease category is supported.
Estrategia preventiva para el control de la caries dental aplicada a una población infantil del Estado Mérida
(2010) Lisbeth Sosa; Karla Andreína Padrón Durán; Beatriz Pachano; Marizoila Diaz; A.M. Rosales
Los programas para la prevención y control de la caries dental tienen como meta disminuir la incidencia de esta enfermedad, sin embargo, los casos nuevos aumentan y los talleres y jornadas educativas no siempre han dado resultado. Esta investigación longitudinal tuvo como objetivo evaluar la efectividad de una estrategia preventiva para el control de la caries dental, luego de transcurrir\nun año de su aplicación. La muestra estuvo conformada por 25 escolares entre 8 y 11 años de edad, de clase media baja; se evaluaron las medidas de higiene bucal aplicadas por los niños (as) y se determinó la prevalencia e incidencia de caries dental. Los resultados de este estudio indican que después de transcurrido un año de aplicación de la estrategia preventiva, el índice CPOD aumento\nde 0,84 a 1,45, no ocurriendo lo mismo con el índice de ceod que disminuyo de 3 a 1,46. La Prueba t tanto para el CPOD como para el ceod no fueron estadísticamente significativas (p=,890 y 2,077 respectivamente). En este estudió se concluye que la estrategia preventiva aplicada no fue efectiva en el control de la caries dental, por lo que se sugiere monitorear a la población\ninfantil después de la implementación de las medida preventivas, aumentar el tiempo de duración de estos programas y motivar a los representantes para que participen activamente en el desarrollo de los mismos.
Evaluación de la eficacia de la técnica de cepillado de bass modificada a través de un metodo de enseñanza intraoral y otro extraoral
(2012) B Lorena Dávila; Lisbeth Sosa; Daniela Ramírez; A Susana Arteaga; Francisco Salvador Palacios
Teaching the mechanical control of supragingival plaque is very important because its purpose is to prevent periodontal disease and create a positive attitude in the patient, inform and motivate. It aims to assess the effectiveness of the Bass brushing technique modified by teaching methods intraoral and extraoral, for mechanical control of dental plaque. We selected 40 patients between 20 and 30 years old, male and female, divided into two groups: group A (20 patients) who received a demonstration of the technique of brushing with intraoral method and group B (20 patients) who received a demonstration of the technique of brushing with extraoral method. Variable was controlled reinforcement and motivation brushing technique, dividing the groups A and B into four subgroups, groups (A1 and B1) were motivation and reinforcement, and the other two groups (A2 and B2) did not. The percentage of supragingival plaque before brushing technique explain between patients in group A was 53.47% while in group B was 45.98%. After explaining the brushing technique in group A decreased to 32.42%, while in group B decreased to 34.76% (p> 0.005). We conclude that the explanation of the technique of brushing with intraoral teaching method proves to be simple, practical and effective for the control of dental plaque,being even more efficient when combined with the reinforcement and motivation of the patient between appointments.
Gingivitis inducida por biopelícula dental y enfermedades gingivales no inducidas por biopelícula dental
(2020) Lorena Dávila B.; Ilusión Romero; Gredy Lugo; Xiomara Gimenéz; Tabatha Rojas; Caroll Yibrín; Lisbeth Sosa; Johelsy Infante; Susana Arteaga; María Palacios
The objective of this review is to know the scientific evidences that allow to establish the bases of the changes applied to the classification of the diseases and conditions that affect the periodontium of protection so that the diagnosis is based on the definition of cases. The information provided provides useful diagnostic, prevention, therapeutic and epidemiological strategies for clinicians and researchers in order to diagnose and properly manage the patient. Common clinical features of gingival conditions induced by biofilm include: a) clinical signs and symptoms of inflammation limited to the gum, b) reversibility of inflammation by removing or altering the biofilm, c) presence of a high biofilm load bacterial to initiate inflammation; d) modifying factors that can alter the severity of inflammation and e) stable levels of insertion, over a periodontium that may or may not have a history of insertion loss or alveolar bone. The simplified taxonomy of gingival conditions includes: 1) introduction of the term “incipient gingivitis”; 2) description of the extent and severity of gingival inflammation; 3) description of the extent and severity of gingival enlargement; 4) reduction of the categories of taxonomy of plaque-induced gingival disease; 5) use of the term necrotizing diseases to encompass gingivitis, periodontitis and stomatitis necrotizing, 6) consideration of linear erythema as oral candidiasis; 7) creation of a more complete nomenclature of pathologies related to non-biofilm-induced diseases that includes the International Code of Diseases ICD-10. In conclusion, biofilm-induced gingivitis is classified by site, in an intact periodontium and in a reduced periodontium. According to its extension, it is classified as localized with SS =10% and =30%, without insertion loss or radiographic bone loss and generalized with SS> 30%, without insertion loss or radiographic bone loss. In the periodontium the first signs of undiagnosed systemic diseases and conditions can be reflected, as well as oral manifestations of some pathologies. Biofilm control in systemic patients is essential to prevent complications.
Purificación de fibroblastos gingivales a partir de tejido de la mucosa bucal
(Universidad Internacional de La Rioja, 2012) Karla Padrón; Siham Salmen; Lisbeth Berrueta; E. González González; Lorena Dávila; Joselyn Rojas; Lisbeth Sosa; Daniela Olávez; Eduvigis Solórzano
Fibroblasts are widely used in regenerative medicine, as key elements in the restoration of the gingival tissue and facial\ntreatments. The aim of this study was to standardize in our laboratory a method to obtain highly pure fibroblasts from\ngingival tissue. In order to do that, cells were mechanically disaggregated from gingival tissue and separated by ficoll\nhypaque density gradients. This procedure was performed several times yielding an enriched culture of adherent cells,\nwhere 51% resulted positive for the fibroblast marker ER-TR7. Our results indicate that the method used, allow to obtain\nfibroblasts from gingival tissue; cells with great potential in the field of regenerative medicine and it represents, in our\ncommunity, the first step to implement therapeutic strategies that will allow the restoration of damaged tissues,\nparticularly in the oral mucosa.
Relación entre periodontitis y enfermedades sistémicas según la nueva clasificación de enfermedades periodontales y periimplantares
(2020) Ilusión Romero; Xiomara Gimenéz; Gredy Lugo; Lorena Dávila B.; Caroll Yibrín; Tabatha Rojas; Rodolfo Gutiérrez Palacios; Lisbeth Sosa; Susana Arteaga; Johelsy Infante
Periodontitis is an infectious disease characterized by inflammation mediated by the host’s immune system and that is associated with specific microorganisms, resulting in the loss of periodontal insertion. This immune response may vary in each person; and if the organism is affected by some systemic disease, the periodontium may present manifestations of said disease. The objective is to review the proposed new classification of periodontal and peri-implant diseases and compare it with that of 1999, in relation to the association of periodontitis and systemic diseases. The findings obtained were diseases and systemic conditions that affect the periodontal insertion apparatus are distributed in three large groups. In the first one there are rare diseases that have a greater impact on the insertion apparatus, resulting in an early presentation of severe periodontitis, in the second they describe the conditions that have a moderate impact on the severity of periodontitis that have shown a increased prevalence and severity of the disease, but they do not have a specific clinical presentation that differentiates them from chronic periodontitis and ultimately the conditions that can cause the destruction of periodontal insertion independent of dental biofilm-induced periodontitis develop. In conclusion it can be pointed out that the new classification allows to identify in greater depth according to periodontal pathology, the severity of the systemic manifestation.
Repercusión periodontal de las deformidades y condiciones mucogingivales
(2020) Ilusión Romero; Tabatha Rojas; Lorena Dávila B.; Gredy Lugo; Caroll Yibrín; Xiomara Gimenéz; Susana Arteaga; Rodolfo Gutiérrez Palacios; Johelsy Infante; Lisbeth Sosa
Las condiciones mucogingivales han sido objeto de estudio en el area de la periodoncia desde las primeras decadas del siglo XX, actualmente estan incluidas en la clasificacion de las enfermedades periodontales como otras condiciones que pueden afectar el periodonto. Se propuso realizar una revision bibliografica de la clasificacion actual y compararla con la del ano 1999. Esta nueva clasificacion amplia el analisis de las recesiones gingivales y la falta de tejido queratinizado. Asimismo, ofrece la posibilidad de mejorar la orientacion con respecto al tratamiento, debido a que se analizan diversos factores como el espesor gingival, ancho gingival, presencia de lesiones cervicales no cariosas, hipersensibilidad dentinaria y por primera vez se toma en cuenta la percepcion estetica que tiene el paciente, aplicando el Indice de Sonrisa Estetica. Tambien se incluye el termino condicion mucogingival normal y se actualiza la definicion de deformidades mucogingivales y recesion gingival. Se concluyo que la nueva clasificacion de las recesiones gingivales esta basada en la perdida de insercion interproximal y combina parametros clinicos, incluido el fenotipo gingival y las caracteristicas de la superficie radicular expuesta, buscando obtener mejores resultados en el tratamiento.
Usos de la melatonina en odontología. Revisión de la literatura
(2017) Lisbeth Sosa; B Lorena Dávila; Karla Andreína Padrón Durán
Las investigaciones recientes describen a la melatonina como una indolamina secretada por la glándula pineal, siendo\nuno de los principales antioxidantes endógenos. Sus usos en medicina y odontología se han incrementado debido a\nsus propiedades como depurador de radicales libres, como inmunomodulador y como un agente capaz de estimular el\nremodelado óseo. Esta revisión tiene como objetivo indagar en la literatura científica a través de las bases de datos de PubMed, Science Direct, Bireme, LILACS y Cochrane base, estudios que avalen el uso de la melatonina en odontología,\nen áreas como periodoncia e implantología principalmente en el tratamiento de la periodontitis crónica y en la\noseointegración de implantes dentales.