Browsing by Autor "Lorenza Pratali"
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Item type: Item , Exaggerated Pulmonary Hypertension and Right Ventricular Dysfunction in High-Altitude Dwellers With Patent Foramen Ovale(Elsevier BV, 2014) Roman Brenner; Lorenza Pratali; Stefano F. Rimoldi; Carla Ximena Murillo Jauregui; Rodrigo Soria; Emrush Rexhaj; Carlos Salinas Salmón; Mercedes Villena; Catherine Romero; Cláudio SartoriItem type: Item , Exaggerated systemic oxidative‐inflammatory‐nitrosative stress in chronic mountain sickness is associated with cognitive decline and depression(Wiley, 2018) Damian M. Bailey; Julien V. Brugniaux; Teresa Filipponi; Christopher J. Marley; Benjamin S. Stacey; Rodrigo Soria; Stefano F. Rimoldi; David Černý; Emrush Rexhaj; Lorenza PrataliChronic mountain sickness (CMS) is a maladaptation syndrome encountered at high altitude (HA) characterised by severe hypoxaemia that carries a higher risk of stroke and migraine and is associated with increased morbidity and mortality. The present cross-sectional study examined to what extent exaggerated systemic oxidative-inflammatory-nitrosative stress (OXINOS), defined by an increase in free radical formation and corresponding decrease in vascular nitric oxide (NO) bioavailability, is associated with impaired cerebrovascular function, accelerated cognitive decline and depression in CMS. Venous blood was obtained from healthy male lowlanders (80 m, n = 17), and age- and gender-matched HA dwellers born and bred in La Paz, Bolivia (3600 m) with (CMS+, n = 23) and without (CMS-, n = 14) CMS. We sampled blood for oxidative (electron paramagnetic resonance spectroscopy, HPLC), nitrosative (ozone-based chemiluminescence) and inflammatory (fluorescence) biomarkers. We employed transcranial Doppler ultrasound to measure cerebral blood flow (CBF) and reactivity. We utilised psychometric tests and validated questionnaires to assess cognition and depression. Highlanders exhibited elevated systemic OXINOS (P < 0.05 vs. lowlanders) that was especially exaggerated in the more hypoxaemic CMS+ patients (P < 0.05 vs. CMS-). OXINOS was associated with blunted cerebral perfusion and vasoreactivity to hypercapnia, impaired cognition and, in CMS+, symptoms of depression. Collectively, these findings are the first to suggest that a physiological continuum exists for hypoxaemia-induced OXINOS in HA dwellers that when excessive is associated with accelerated cognitive decline and depression, helping identify those in need of specialist neurological assessment and support.Item type: Item , Exercise Induces Rapid Interstitial Lung Water Accumulation in Patients With Chronic Mountain Sickness(Elsevier BV, 2011) Lorenza Pratali; Stefano F. Rimoldi; Emrush Rexhaj; Damian Hutter; Francesco Faita; Carlos Salinas Salmón; Mercedes Villena; Rosa Sicari; Eugenio Picano; Yves AllemannItem type: Item , Oxidative-Nitrosative Stress and Systemic Vascular Function in Highlanders With and Without Exaggerated Hypoxemia(Elsevier BV, 2013) Damian M. Bailey; Stefano F. Rimoldi; Emrush Rexhaj; Lorenza Pratali; Carlos Salinas Salmón; Mercedes Villena; Jane McEneny; Ian Young; Pascal Nicod; Yves AllemannItem type: Item , RV Contractility and Exercise-Induced Pulmonary Hypertension in Chronic Mountain Sickness(Elsevier BV, 2013) Lorenza Pratali; Yves Allemann; Stefano F. Rimoldi; Francesco Faita; Damian Hutter; Emrush Rexhaj; Roman Brenner; Damian M. Bailey; Cláudio Sartori; Carlos Salinas SalmónItem type: Item , Sleep-Disordered Breathing and Vascular Function in Patients With Chronic Mountain Sickness and Healthy High-Altitude Dwellers(Elsevier BV, 2015) Emrush Rexhaj; Stefano F. Rimoldi; Lorenza Pratali; Roman Brenner; Daniela Andries; Rodrigo Soria; Carlos E. Salinas; Mercedes Villena; Catherine Romero; Yves AllemannItem type: Item , Systemic Vascular Dysfunction in Patients With Chronic Mountain Sickness(Elsevier BV, 2011) Stefano F. Rimoldi; Emrush Rexhaj; Lorenza Pratali; Damian M. Bailey; Damian Hutter; Francesco Faita; Carlos Salinas Salmón; Mercedes Villena; Pascal Nicod; Yves Allemann