Browsing by Autor "Lucia Inchauste"

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Author response: Improving SARS-CoV-2 variants monitoring in the absence of genomic surveillance capabilities: a serological study in Bolivian blood donors in October 2021 and June 2022
(2025) Lucia Inchauste; Elif Nurtop; Lissete Bautista Machicado; Yanine Leigue Roth; Shirley Lenz Gonzales; Maria Luisa Herrera; Katty Mina Villafan; Pedro Mamani Mamani; Marcelo Ramos Espinoza; Juan Carlos Pavel Suarez
Unlike genomic data, serological data have not been previously leveraged to evaluate the SARS-CoV-2 variants circulation. In Bolivia, sustained genomic surveillance capacities were lacking especially at the beginning of the pandemic. In 2021 and 2022 we estimated the prevalence of anti-SARS-CoV-2 antibodies in Bolivian blood donors and explored the feasibility of using virus serum neutralization data for variants thought to have circulated to map their circulation across all departments over a year-long follow-up period. Anti-S1 and anti-NCP SARS-CoV-2 IgGs were studied, along with virus neutralization tests for ancestral-D614G, Gamma, Delta, and Omicron BA.1 lineages of SARS-CoV-2. Between 2021 and 2022, the overall prevalence of anti-S1 and anti-NCP antibodies increased reaching values over 90%, demonstrating that a large proportion of the Bolivian population was no longer naïve to the virus. Viral neutralization data, analyzed through multiple approaches, revealed the spread of the Gamma variant up to 2021, particularly impacting northern departments. In 2022, Gamma continued to circulate in southernmost departments of the country and the emergence of Omicron BA.1 was detected. These trends align with publicly available genomic data from neighboring countries. Our serological analyses successfully identified both new antigenic groups, such as Omicron BA.1, and individual variants related to previously circulating groups, such as Delta. The study contributes insights into overall population immunity to SARS-CoV-2 and variant-specific immunity levels across different regions of Bolivia. It also emphasizes the potency of seroprevalence studies in informing public health decisions and underscore their value in capturing the initial phases of emerging epidemics when variant diversity is limited, facilitating timely genomic surveillance setup.
Impact of rotavirus vaccination on child mortality, morbidity, and rotavirus-related hospitalizations in Bolivia
(Elsevier BV, 2017) Lucia Inchauste; Maritza Patzi; Kjetil Halvorsen; Susana Solano; Raúl Montesano; Volga Iñiguez
Improving SARS-CoV-2 variants monitoring in the absence of genomic surveillance capabilities: a serological study in Bolivian blood donors in October 2021 and June 2022
(2023) Lucia Inchauste; Elif Nurtop; Lissete Bautista Machicado; Yanine Leigue Roth; Shirley Lenz Gonzales; Maria Luisa Herrera; Katty Mina Villafan; Pedro Mamani Mamani; Marcelo Ramos Espinoza; Juan Carlos Pavel Suarez
Abstract Unlike genomic data, serological data have not been previously leveraged to evaluate the SARS-CoV-2 variants circulation. In Bolivia, sustained genomic surveillance capacities were lacking especially at the beginning of the pandemic. In 2021 and 2022 we estimated the prevalence of anti-SARS-CoV-2 antibodies in Bolivian blood donors and explored the feasibility of using virus serum neutralization data for variants thought to have circulated to map their circulation across all departments over a year-long follow-up period. Anti-S1 and anti-NCP SARS-CoV-2 IgGs were studied, along with virus neutralization tests for ancestral-D614G, Gamma, Delta, and Omicron BA.1 lineages of SARS-CoV-2. Between 2021 and 2022, the overall prevalence of anti-S1 and anti-NCP antibodies increased reaching values over 90%, demonstrating that a large proportion of the Bolivian population was no longer naïve to the virus. Viral neutralization data, analyzed through multiple approaches, revealed the spread of the Gamma variant up to 2021, particularly impacting northern departments. In 2022, Gamma continued to circulate in southernmost departments of the country and the emergence of Omicron BA.1 was detected. These trends align with publicly available genomic data from neighboring countries. Our serological analyses successfully identified both new antigenic groups, such as Omicron BA.1, and individual variants related to previously circulating groups, such as Delta. The study contributes insights into overall population immunity to SARS-CoV-2 and variant-specific immunity levels across different regions of Bolivia. It also emphasizes the potency of seroprevalence studies in informing public health decisions and underscore their value in capturing the initial phases of emerging epidemics when variant diversity is limited, facilitating timely genomic surveillance setup.
Improving SARS-CoV-2 variants monitoring in the absence of genomic surveillance capabilities: a serological study in Bolivian blood donors in October 2021 and June 2022
(2024) Lucia Inchauste; Elif Nurtop; Lissete Bautista Machicado; Yanine Leigue Roth; Shirley Lenz Gonzales; Maria Luisa Herrera; Katty Mina Villafan; Pedro Mamani Mamani; Marcelo Ramos Espinoza; Juan Carlos Pavel Suarez
Abstract Unlike genomic data, serological data have not been previously leveraged to evaluate the SARS-CoV-2 variants circulation. In Bolivia, sustained genomic surveillance capacities were lacking especially at the beginning of the pandemic. In 2021 and 2022 we estimated the prevalence of anti-SARS-CoV-2 antibodies in Bolivian blood donors and explored the feasibility of using virus serum neutralization data for variants thought to have circulated to map their circulation across all departments over a year-long follow-up period. Anti-S1 and anti-NCP SARS-CoV-2 IgGs were studied, along with virus neutralization tests for ancestral-D614G, Gamma, Delta, and Omicron BA.1 lineages of SARS-CoV-2. Between 2021 and 2022, the overall prevalence of anti-S1 and anti-NCP antibodies increased reaching values over 90%, demonstrating that a large proportion of the Bolivian population was no longer naïve to the virus. Viral neutralization data, analyzed through multiple approaches, revealed the spread of the Gamma variant up to 2021, particularly impacting northern departments. In 2022, Gamma continued to circulate in southernmost departments of the country and the emergence of Omicron BA.1 was detected. These trends align with publicly available genomic data from neighboring countries. Our serological analyses successfully identified both new antigenic groups, such as Omicron BA.1, and individual variants related to previously circulating groups, such as Delta. The study contributes insights into overall population immunity to SARS-CoV-2 and variant-specific immunity levels across different regions of Bolivia. It also emphasizes the potency of seroprevalence studies in informing public health decisions and underscore their value in capturing the initial phases of emerging epidemics when variant diversity is limited, facilitating timely genomic surveillance setup.
Improving SARS-CoV-2 variants monitoring in the absence of genomic surveillance capabilities: a serological study in Bolivian blood donors in October 2021 and June 2022
(eLife Sciences Publications Ltd, 2025) Lucia Inchauste; Elif Nurtop; Lissete Bautista Machicado; Yanine Leigue Roth; Shirley Lenz Gonzales; Maria Luisa Herrera; Katty Mina Villafan; Pedro Mamani Mamani; Marcelo Ramos Espinoza; Juan Carlos Pavel Suarez
Background: Unlike genomic data, serological data have not been previously leveraged to evaluate the SARS-CoV-2 variants circulation. In Bolivia, sustained genomic surveillance capacities were lacking, especially at the beginning of the pandemic. Methods: In 2021 and 2022 we estimated the prevalence of anti-SARS-CoV-2 antibodies in Bolivian blood donors and explored the feasibility of using virus serum neutralization data for variants thought to have circulated to map their circulation across all departments over a year-long follow-up period. Anti-S1 and anti-NCP SARS-CoV-2 IgGs were studied, along with virus neutralization tests for ancestral-D614G, Gamma, Delta, and Omicron BA.1 lineages of SARS-CoV-2. Results: Between 2021 and 2022, the overall prevalence of anti-S1 and anti-NCP antibodies increased, reaching values over 90%, demonstrating that a large proportion of the Bolivian population was no longer naïve to the virus. Viral neutralization data, analyzed through multiple approaches, revealed the spread of the Gamma variant up to 2021, particularly impacting northern departments. In 2022, Gamma continued to circulate in southernmost departments of the country, and the emergence of Omicron BA.1 was detected. These trends align with publicly available genomic data from neighboring countries. Conclusions: Our serological analyses successfully identified both new antigenic groups, such as Omicron BA.1, and individual variants related to previously circulating groups, such as Delta. The study contributes insights into overall population immunity to SARS-CoV-2 and variant-specific immunity levels across different regions of Bolivia. It also emphasizes the potency of seroprevalence studies in informing public health decisions and underscores their value in capturing the initial phases of emerging epidemics when variant diversity is limited, facilitating timely genomic surveillance setup. Funding: This study was supported by the French National Research Institute for Sustainable Development (IRD), the project EMERGEN-PRI #22275 of the ANRS I MIE (INSERM), and the European Union’s Horizon 2020 research and innovation program (European Virus Archive Global, grant agreement No. 871029). The funders of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report.
Improving SARS-CoV-2 variants monitoring in the absence of genomic surveillance capabilities: a serological study in Bolivian blood donors in October 2021 and June 2022
(eLife Sciences Publications Ltd, 2024) Lucia Inchauste; Elif Nurtop; Lissete Bautista Machicado; Yanine Leigue Roth; Shirley Lenz Gonzales; Maria Luisa Herrera; Katty Mina Villafan; Pedro Mamani Mamani; Marcelo Ramos Espinoza; Juan Carlos Pavel Suarez
This study was supported by the French National Research Institute for Sustainable Development (IRD), the project EMERGEN-PRI #22275 of the ANRS I MIE (INSERM), and the European Union's Horizon 2020 research and innovation program (European Virus Archive Global, grant agreement No. 871029). The funders of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report.
Improving SARS-CoV-2 variants monitoring in the absence of genomic surveillance capabilities: a serological study in Bolivian blood donors in October 2021 and June 2022
(2025) Lucia Inchauste; Elif Nurtop; Lissete Bautista Machicado; Yanine Leigue Roth; Shirley Lenz Gonzales; Maria Luisa Herrera; Katty Mina Villafan; Pedro Mamani Mamani; Marcelo Ramos Espinoza; Juan Carlos Pavel Suarez
Abstract Unlike genomic data, serological data have not been previously leveraged to evaluate the SARS-CoV-2 variants circulation. In Bolivia, sustained genomic surveillance capacities were lacking especially at the beginning of the pandemic. In 2021 and 2022 we estimated the prevalence of anti-SARS-CoV-2 antibodies in Bolivian blood donors and explored the feasibility of using virus serum neutralization data for variants thought to have circulated to map their circulation across all departments over a year-long follow-up period. Anti-S1 and anti-NCP SARS-CoV-2 IgGs were studied, along with virus neutralization tests for ancestral-D614G, Gamma, Delta, and Omicron BA.1 lineages of SARS-CoV-2. Between 2021 and 2022, the overall prevalence of anti-S1 and anti-NCP antibodies increased reaching values over 90%, demonstrating that a large proportion of the Bolivian population was no longer naïve to the virus. Viral neutralization data, analyzed through multiple approaches, revealed the spread of the Gamma variant up to 2021, particularly impacting northern departments. In 2022, Gamma continued to circulate in southernmost departments of the country and the emergence of Omicron BA.1 was detected. These trends align with publicly available genomic data from neighboring countries. Our serological analyses successfully identified both new antigenic groups, such as Omicron BA.1, and individual variants related to previously circulating groups, such as Delta. The study contributes insights into overall population immunity to SARS-CoV-2 and variant-specific immunity levels across different regions of Bolivia. It also emphasizes the potency of seroprevalence studies in informing public health decisions and underscore their value in capturing the initial phases of emerging epidemics when variant diversity is limited, facilitating timely genomic surveillance setup.
Prevalence of enteric pathogens in mothers and children from communities in the La Paz River Basin Bolivia; associations with water, sanitation, and hygiene conditions
(UWA Publishing, 2026) Cinthia Copeticona-Callejas; Sònia Jiménez; Alejandra Torrez-Mamani; Belén Choque-Pardo; Jorge Agramont; Josué Mamani-Jarro; Lucia Inchauste; Stéphane Priet; Adriana Espinoza Soto; Carla Liera
Enteric infections remain a major public health challenge in low- and middle-income countries, disproportionately affecting young children. We conducted a cross-sectional study to characterize the prevalence of enteropathogens among mothers and children from peri-urban and rural communities in the La Paz River Basin Bolivia, and to examine associations with water, sanitation, and hygiene (WASH) conditions. Fecal samples were analyzed by real-time PCR to detect 21 viral, bacterial, and parasitic pathogens, alongside household surveys and water quality assessments. Sixteen pathogens were detected, 85% of participants carried at least one pathogen, with frequent coinfections. The most prevalent pathogens were Helicobacter pylori, adenovirus, EPEC, Giardia lamblia, and Shigella. Pathogen carriage was higher in rural than in peri-urban settings, with bacterial infections predominating in the lower basin and viral infections in the upper basin. Children carried more viral and parasitic pathogens, while mothers had more bacterial pathogens. Significant mother-child concordance was observed for several pathogens, supporting shared household exposures. Enteric pathogen carriage was strongly associated with drinking water source, sanitation practices, housing quality, and hygiene behaviors, particularly reliance on cistern/spring water, open defecation, and inadequate hand hygiene. These findings highlight a substantial and heterogeneous burden of enteric infections, underscoring the need for integrated WASH interventions.
The spatiotemporal ecology of Oropouche virus across Latin America: a multidisciplinary, laboratory-based, modelling study
(Elsevier BV, 2025) Carlo Fischer; Anna Frühauf; Lucia Inchauste; Murilo Henrique Anzolini Cassiano; Heriberto Arévalo Ramirez; Karine Barthélémy; Lissete Bautista Machicado; Fernando A. Bozza; Carlos Brites; Miguel M. Cabada
For the Spanish and Portuguese translations of the abstract see Supplementary Materials section.