Browsing by Autor "Luciana R. Tallini"

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    Alkaloid Profile Characterisation and Bioactivity Evaluation of Bolivian Hippeastrum Species (Amaryllidaceae) as Cholinesterase Inhibitors
    (Multidisciplinary Digital Publishing Institute, 2025) María Lenny Rodríguez-Escobar; Rogéria Inês Rosa Lara; Margoth Atahuachi Burgos; A C.; Carla Maldonado; Jaume Bastida; Luciana R. Tallini; Laura Torras‐Claveria
    Amaryllidaceae alkaloids from the Amaryllidoideae subfamily exhibit broad pharmacological activities, including neuroprotection and anticancer effects. Galanthamine is a key compound for Alzheimer's therapy. The <i>Hippeastrum</i> genus, particularly in Bolivia, offers significant potential for novel drug discovery, emphasising the need for conservation and further phytochemical research. Twenty-seven samples from Bolivian <i>Hippeastrum</i> species were investigated in terms of their alkaloid profile and anticholinesterase activity. The phytochemical analysis of Bolivian <i>Hippeastrum</i> species via GC-MS identified 48 Amaryllidaceae alkaloids, displaying diverse structural groups with potential pharmacological significance. Lycorine- and Homolycorine-type alkaloids were predominant, particularly in <i>H. chionedyanthum</i> and <i>H. haywardii</i>, with high concentrations of lycorine, a promising anticancer compound. The species <i>H. evansiarum</i> and <i>H. mollevillquense</i> contained notable quantities of Galanthamine type alkaloids, relevant for Alzheimer's treatment. This study also highlights variability in acetylcholinesterase and butyrylcholinesterase inhibitory activities, with <i>H. lara-ricoi</i> and <i>H. haywardii</i> demonstrating strong inhibition. These findings suggest that <i>Hippeastrum</i> species are a valuable source of bioactive compounds, warranting further research into their therapeutic applications.
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    Pharmacological Potential of Peruvian Eustephia Species (Amaryllidaceae): Alkaloid Diversity, Cholinesterase Inhibition, and Anti-Trypanosoma cruzi Activity
    (Multidisciplinary Digital Publishing Institute, 2025) Olimpia Llalla-Córdova; Javier E. Ortiz; Mauricio Piñeiro; Luciana R. Tallini; Laura Torras‐Claveria; Hibert Huaylla; Ana María Mejía‐Jaramillo; Omar Triana‐Chávez; Edison Osorio; Lorena Luna
    The Amaryllidaceae family represents a prolific source of pharmacologically active compounds, boasting over 700 diverse alkaloids identified to date. However, the genus <i>Eustephia</i> (Amaryllidoideae subfamily) remains largely unexplored. This study focused on the alkaloid profiles and pharmacological potential of bulb and leaves extracts from three Peruvian <i>Eustephia</i> species (<i>E. coccinea</i>, <i>E. darwinii</i>, and <i>E. hugoei</i>). The phenolic and flavonoid levels as well as the antioxidant activity of the methanolic extracts, were determined. Twenty-six alkaloids were identified in the alkaloid-enriched extracts (AEEs). Homolycorine-type alkaloids predominated in <i>E. darwinii</i> and <i>E. hugoei</i>, whereas <i>E. coccinea</i> displayed greater chemical diversity showing assoanine as the main detected alkaloid. In addition, candimine was widely distributed across species. AEEs showed stronger enzyme inhibition of acetylcholinesterase (AChE) compared to butyrylcholinesterase (BuChE). Notably, the AEE from <i>E. coccinea</i> leaves showed the highest AChE inhibition (IC<sub>50</sub> = 1.82 μg/mL), while the AEE from bulbs exhibited the strongest BuChE inhibitory activity (IC<sub>50</sub> = 61.22 μg/mL). Regarding anti-<i>T. cruzi</i> effect, the <i>E. darwinii</i> bulbs AEE was most potent and selective against amastigote forms (IC<sub>50</sub> = 2.1 μg/mL; SI = 8.83). These findings underscore the potential of Peruvian <i>Eustephia</i> species as promising sources of pharmacologically relevant alkaloids, with possible applications in neurodegenerative disorders and Chagas disease.