Browsing by Autor "M. Silva"

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    DOENÇA DIVERTICULAR DOS CÓLONS: EVOLUÇÃO DA ABORDAGEM TERAPÊUTICA
    (2025) Antônio Luiz dos Santos Filho; Kerolaine Silva Fonseca; Thalia Ely Cervejeira; Ana Clara Novais Viana; Antonio Denizar Costa Neto; A. Sousa; Fernanda Paula Roncon Santana; Isadora Letícia de Pontes Alves Pequeno; M. Silva; Tiago Silva
    Nas últimas décadas a incidência da moléstia diverticular do cólon e de suas complicações tem aumentado. Durante esse período o número de publicações a respeito do tema se expandiu, bem como as opções terapêuticas. Apesar disso, muitas dúvidas persistem e as decisões terapêuticas continuam relativamente imutáveis, baseadas muitas vezes em dados antigos e de baixo poder estatístico. Nesta revisão apresentamos as evidências científicas atuais acerca da terapêutica desta complexa patologia.
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    SBRT for Uncomplicated Bone Metastases in the Spine from Lung Cancer
    (2025) M. Silva; C. E. Cunha; Cristiane Domingos de Aquino; Luciana Carla Martins de Aquino; Paulo César Peregrino Ferreira
    Introduction: Bone metastases (BM) are common in several types of cancer, especially breast, prostate, lung, kidney and thyroid. Radiotherapy (RT) is a standard treatment for symptomatic BM, providing pain relief with minimal toxicity. Stereotactic body RT (SBRT) has emerged as an advanced technique to treat uncomplicated spinal bone metastases (UNSM) in patients with lung cancer. Methodology: A review of the scientific literature on the use of SBRT for UNSM was performed. The review included randomized controlled trials and meta-analyses, focusing on patient selection, treatment techniques and clinical outcomes. Inclusion criteria were defined, excluding imminent pathological fractures or spinal cord compression. Results: SBRT showed high rates of local control of metastases, reaching up to 90% in one year. There was significant pain relief and improvement in the quality of life of patients. Toxicities were minimal, with rare serious complications reported. Studies indicate that SBRT offers additional benefits, allowing dose escalation and minimizing toxicity compared to conventional RT. Discussion: SBRT is a promising approach to treat MONC, especially in patients with oligometastatic disease. Early detection and planned treatment of asymptomatic bone metastases can prevent serious complications, such as pathological fractures and spinal cord compression, improving pain-free survival. Current evidence supports the efficacy of SBRT, but prospective clinical trials are needed to optimize treatment protocols and patient selection. Multidisciplinary collaboration is essential for successful patient management. Conclusion: SBRT represents a significant advance in RT for uncomplicated spinal bone metastases in lung cancer, combining clinical efficacy and safety, with a positive impact on patients' quality of life. This innovative technique offers new therapeutic possibilities that should be considered in selected patients.