Browsing by Autor "M. Valdivia"

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<b>BACTERIOTERAPIA EN ONCOLOGÍA: AVANCES EN EL USO DE MICROORGANISMOS PARA OPTIMIZAR LA RESPUESTA INMUNITARIA ANTITUMORAL</b>
(2025) M. Valdivia; Sofia Ximena Azbell Flores
Cancer represents a significant global challenge due to its biological complexity, tumor heterogeneity, and the limitations of conventional therapies such as chemotherapy, radiotherapy, and certain immunotherapies, which often exhibit low specificity and considerable side effects. In this context, oncological bacteriotherapy has emerged as an innovative alternative within the field of immunotherapy, utilizing genetically modified bacteria to specifically target the tumor microenvironment. This review focused on analyzing the therapeutic potential of five bacterial species: Clostridium novyi-NT, Salmonella enterica serovar Typhimurium, Listeria monocytogenes, Escherichia coli, and Bifidobacterium longum, their mechanisms of action, efficacy, advantages, limitations, progress in preclinical and clinical studies, and their potential use in combination with other therapies. Additionally, an analysis of empirical data reported up to 2020 was conducted, identifying positive trends in success rates. Based on this, estimated projections for the 2025–2030 period was developed, outlining an optimistic yet realistic scenario that considers plausible clinical and statistical criteria to envision a future in which modified bacteria could become effective, customizable, and safe therapeutic tools. This study proposes and scientifically supports the value of bacteriotherapy as an emerging avenue for cancer treatment. By demonstrating tumor specificity, genetic engineering capabilities, and a low immunogenic profile, this work seeks to promote its development and clinical application.
Strategic Thinking: a Resource to Generate Value and Cross the Valley of Death of SMEs
(2024) Galvarino Casanueva-Yáñez; Jorge Torres-Vásquez; Mitzi Lourdes del Carmen Linares-Vizcarra; M. Valdivia; Evelyn Montero-Zuñiga; Reina Pérez-Vargas; Claudia Torres-Calvimonte; Raúl Rengifo-Lozano
The most challenging period for a company is the first three years following its inception, a period often referred to as the "valley of death." This article examines the factors contributing to the high mortality rate of small and medium-sized enterprises (SMEs) in the town of Melipilla, Chile, and presents potential strategies for reducing or preventing this mortality. The study employs an exploratory-descriptive approach, utilizing a qualitative methodology and a cross-sectional sample size collected through convenience sampling and semi-structured interviews. Upon analysis of the aforementioned data, it becomes evident that contemporary SMEs have more convenient access to capital, technology, information, and financing. These resources, which were once considered distinctive and crucial for competitive advantage, are no longer as pivotal in generating value. Conversely, the findings highlight the pivotal role of human resources and their strategic management in developing distinctive competencies, which are essential for SMEs to create value and ensure long-term sustainability.
Strategic Thinking: A Resource to Generate Value and Cross the Valley of Death of SMEs
(2024) Galvarino Casanueva-Yáñez; Jorge Torres-Vásquez; Mitzi Lourdes del Carmen Linares-Vizcarra; M. Valdivia; Evelyn Montero-Zuñiga; Reina Pérez-Vargas; Claudia Torres-Calvimonte; Raúl Rengifo-Lozano
The most challenging period for a company is the first three years following its inception, a period often referred to as the "valley of death." This article examines the factors contributing to the high mortality rate of small and medium-sized enterprises (SMEs) in the town of Melipilla, Chile, and presents potential strategies for reducing or preventing this mortality. The study employs an exploratory-descriptive approach, utilizing a qualitative methodology and a cross-sectional sample size collected through convenience sampling and semi-structured interviews. Upon analysis of the aforementioned data, it becomes evident that contemporary SMEs have more convenient access to capital, technology, information, and financing. These resources, which were once considered distinctive and crucial for competitive advantage, are no longer as pivotal in generating value. Conversely, the findings highlight the pivotal role of human resources and their strategic management in developing distinctive competencies, which are essential for SMEs to create value and ensure long-term sustainability.